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1.发明授权Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins 失效通过使用来自热休克蛋白的非翻译区改善多肽翻译的方法公开(公告)号：US07351818B2
公开(公告)日：2008-04-01
申请号：US11167614
申请日：2005-06-27
Applicant: Herve Jean-Clement Coste , Jonathan Henry Ellis
Inventor： Herve Jean-Clement Coste , Jonathan Henry Ellis
IPC: C07H21/04
CPC classification number: C07K14/47 , A61K2039/53 , C12N15/85 , C12N2830/002 , C12N2830/85 , C12N2840/105 , C12N2840/203
Abstract: Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expression systems. The invention is also useful, for example, in the treatment of a patient suffering from a deficiency in the expression of a polypeptide and in the provision of vaccines.
Abstract translation: 可以使用与热休克反应相关的非翻译区域，以获得不一定通常与热休克反应相关的多肽的翻译效率。 这允许开发大大改进的表达系统。 本发明也可用于例如治疗患有多肽表达缺陷的患者和提供疫苗。
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2.发明授权Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins 失效通过使用来自热休克蛋白的非翻译区改善多肽翻译的方法公开(公告)号：US07034142B1
公开(公告)日：2006-04-25
申请号：US09936506
申请日：2000-03-09
Applicant: Herve Jean-Clement Coste , Jonathan Henry Ellis
Inventor： Herve Jean-Clement Coste , Jonathan Henry Ellis
IPC: C07H21/04
CPC classification number: C07K14/47 , A61K2039/53 , C12N15/85 , C12N2830/002 , C12N2830/85 , C12N2840/105 , C12N2840/203
Abstract: Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expression systems. The invention is also useful, for example, in the treatment of a patient suffering from a deficiency in the expression of a polypeptide and in the provision of vaccines.
Abstract translation: 可以使用与热休克反应相关的非翻译区域，以获得不一定通常与热休克反应相关的多肽的翻译效率。 这允许开发大大改进的表达系统。 本发明也可用于例如治疗患有多肽表达缺陷的患者和提供疫苗。
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公开(公告)号：US08637018B2
公开(公告)日：2014-01-28
申请号：US13315358
申请日：2011-12-09
Applicant: Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin
Inventor： Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
Abstract: The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
Abstract translation: 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
Applicant: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
Inventor： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
Abstract translation: 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20100047243A1
公开(公告)日：2010-02-25
申请号：US12526966
申请日：2008-02-12
Applicant: Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
Inventor： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
IPC: A61K39/395 , C07K16/00 , C12N5/10 , C12P21/04
CPC classification number: C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
Abstract translation: 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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Patent Agency Ranking
公开(公告)号：US09193784B2
公开(公告)日：2015-11-24
申请号：US13491810
申请日：2012-06-08
Applicant: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
Inventor： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC: C07K16/18 , A61K39/395 , A61K39/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
Abstract: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
Abstract translation: 结合人和淀粉样蛋白肽的抗体，以所述抗体为特征的疾病或病症的特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物的方法，包含所述抗体的药物组合物和制备方法。
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公开(公告)号：US08227576B2
公开(公告)日：2012-07-24
申请号：US12294438
申请日：2007-03-27
Applicant: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
Inventor： Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC: C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
Abstract: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
Abstract translation: 结合人和淀粉样蛋白肽的抗体，以所述抗体为特征的疾病或病症的特征在于淀粉样蛋白水平升高或淀粉样沉积的方法，包含所述抗体的药物组合物和制造方法。
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公开(公告)号：US20110206686A1
公开(公告)日：2011-08-25
申请号：US12681413
申请日：2008-10-03
Applicant: Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
Inventor： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
IPC: A61K39/395 , C07K16/24 , C12N1/00 , C12N5/10 , A61P29/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/00 , A61P3/10 , A61P11/06 , A61P37/08 , A61P37/06
CPC classification number: C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
Abstract translation: 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿关节炎（RA）中的用途。
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公开(公告)号：US08858943B2
公开(公告)日：2014-10-14
申请号：US12679917
申请日：2008-09-23
Applicant: Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
Inventor： Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC: A61K39/395 , A61K35/30 , A61K35/44 , C07K16/18 , A61K39/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
Abstract: The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
Abstract translation: 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法，其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物，特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成， 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白，特别是人和淀粉样蛋白肽。
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公开(公告)号：US20110262430A1
公开(公告)日：2011-10-27
申请号：US12671607
申请日：2008-07-28
Applicant: Jonathan Henry Ellis , Paul Andrew Hamblin
Inventor： Jonathan Henry Ellis , Paul Andrew Hamblin
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-IR, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
Abstract translation: 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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