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公开(公告)号：US08637018B2
公开(公告)日：2014-01-28
申请号：US13315358
申请日：2011-12-09
Applicant: Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin
Inventor： Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K39/00 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
Abstract: The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential.
Abstract translation: 本发明公开了人源化抗IL-18抗体，制备方法和用所述抗体治疗的方法。 还公开了使用例如表面等离子体共振以鉴定具有治疗潜力的抗体的筛选方法。
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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
Applicant: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
Inventor： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC: C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
Abstract translation: 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20100047243A1
公开(公告)日：2010-02-25
申请号：US12526966
申请日：2008-02-12
Applicant: Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
Inventor： Michael Neil Burden , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Radba Shah
IPC: A61K39/395 , C07K16/00 , C12N5/10 , C12P21/04
CPC classification number: C07K16/2863 , C07K2317/24 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-1R, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
Abstract translation: 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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公开(公告)号：US20110206686A1
公开(公告)日：2011-08-25
申请号：US12681413
申请日：2008-10-03
Applicant: Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
Inventor： Gary Peter Bembridge , Jane Elizabeth Clarkson , Jonathan Henry Ellis , Paul Andrew Hamblin , George Kopsidas , Alan Peter Lewis , Ruth Mcadam
IPC: A61K39/395 , C07K16/24 , C12N1/00 , C12N5/10 , A61P29/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P11/00 , A61P3/10 , A61P11/06 , A61P37/08 , A61P37/06
CPC classification number: C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).
Abstract translation: 本发明涉及到人IL-23的抗原结合蛋白，含有它们的药物制剂以及这种抗原结合蛋白在治疗和/或预防炎性疾病如类风湿关节炎（RA）中的用途。
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公开(公告)号：US08680245B2
公开(公告)日：2014-03-25
申请号：US13321982
申请日：2010-05-26
Applicant: Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
Inventor： Claire Ashman , Jonathan Henry Ellis , Paul Andrew Hamblin , Alan Peter Lewis , Martin Anibal Orecchia
IPC: C07K16/24
CPC classification number: C07K16/244 , A61K2039/505 , C07K16/247 , C07K16/468 , C07K2317/24 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/76 , Y02A50/41
Abstract: The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF.
Abstract translation: 本发明涉及抗人IL-13的抗原结合蛋白，包括抗IL-13抗体和抗IL-3 /抗-IL-4mAbdAb，含有它们的药物制剂以及该抗原结合蛋白在 治疗和/或预防炎性疾病如哮喘或IPF。
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Patent Agency Ranking
公开(公告)号：US20120070436A1
公开(公告)日：2012-03-22
申请号：US13322200
申请日：2010-05-26
Applicant: Richard Lewis Easeman , Jonathan Henry Ellis , Paul Andrew Hamblin
Inventor： Richard Lewis Easeman , Jonathan Henry Ellis , Paul Andrew Hamblin
IPC: A61K39/395 , C12N15/62 , C12N5/10 , C12P21/00 , A61P35/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P25/00 , C12N1/21 , C12N1/19 , C12N1/15 , C07K19/00 , A61P1/00
CPC classification number: C07K16/22 , A61K47/6811 , A61K47/6835 , C07K16/241 , C07K16/2863 , C07K16/32 , C07K2317/569 , C07K2319/30
Abstract: The present invention relates to antigen binding proteins comprising a receptor-Fc fusion which is linked to one or more epitope-binding domains, methods for making such proteins, and uses thereof.
Abstract translation: 本发明涉及包含与一个或多个表位结合结构域连接的受体-Fc融合体的抗原结合蛋白，用于制备此类蛋白质的方法及其应用。
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公开(公告)号：US20110262430A1
公开(公告)日：2011-10-27
申请号：US12671607
申请日：2008-07-28
Applicant: Jonathan Henry Ellis , Paul Andrew Hamblin
Inventor： Jonathan Henry Ellis , Paul Andrew Hamblin
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2887 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: The present invention relates to antibodies or antigen binding fragments thereof which specifically binds to IGF-IR, specifically hIGF-1R. Also disclosed are antibody preparations comprising antibodies or antigen binding fragments of the invention. Methods of producing such antibodies or antigen binding fragments and uses thereof are also included within the scope of the present invention.
Abstract translation: 本发明涉及特异性结合IGF-1R，特别是hIGF-1R的抗体或其抗原结合片段。 还公开了包含本发明的抗体或抗原结合片段的抗体制剂。 生产此类抗体或抗原结合片段的方法及其用途也包括在本发明的范围内。
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公开(公告)号：US20110008345A1
公开(公告)日：2011-01-13
申请号：US12744799
申请日：2008-11-28
Applicant: Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
Inventor： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
CPC classification number: C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
Abstract translation: 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US20100221260A1
公开(公告)日：2010-09-02
申请号：US12097279
申请日：2006-12-14
Applicant: Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
Inventor： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC: A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
Abstract translation: 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20090148905A1
公开(公告)日：2009-06-11
申请号：US12324905
申请日：2008-11-28
Applicant: Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
Inventor： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC: C12P21/02 , C07K16/00 , C07H21/00 , A61K39/395 , C12N5/10
CPC classification number: C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
Abstract translation: 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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