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    Treatment of infectious and inflammatory lesions
    1.
    发明授权
    Treatment of infectious and inflammatory lesions 失效
    治疗感染性和炎症性病变

    公开(公告)号：US5705158A

    公开(公告)日：1998-01-06

    申请号：US469992

    申请日：1995-06-06

    申请人： Hans John Hansen ,  Milton David Goldenberg

    发明人： Hans John Hansen ,  Milton David Goldenberg

    IPC分类号： A61K9/08 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/00 ,  A61K51/10 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P43/00 ,  C12P21/08 ,  C07K16/18

    CPC分类号： A61K47/48546 ,  A61K51/1018 ,  A61K2123/00 ,  Y10S530/866

    摘要： A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types. A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate. A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent. A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.

    摘要翻译： 用于靶向白细胞增生灶的多特异性抗白细胞抗体缀合物包含与至少一种成像剂缀合的至少两种不同的基本单特异性抗体或抗体片段的免疫反应性多特异性复合物，其中至少两种所述抗体或抗体片段特异性结合 到不同的白细胞类型。 用于将成像剂靶向炎性或感染性病变的方法包括以有效量肠胃外注射哺乳动物以靶向上述抗白细胞成像缀合物。 用于靶向白细胞增生灶的治疗性抗白细胞抗体 - 试剂缀合物包含与至少一种治疗性抗微生物剂缀合的至少一种特异性结合至少一种白细胞细胞类型的基本上单特异性抗体或抗体片段的免疫反应性活性基因。 治疗感染性病变的方法包括用有效量的胃肠外注射哺乳动物治疗上述抗白细胞治疗缀合物。

    Cytotoxic therapy for graft rejection
    2.
    发明授权
    Cytotoxic therapy for graft rejection 失效
    移植排斥的细胞毒性治疗

    公开(公告)号：US5843397A

    公开(公告)日：1998-12-01

    申请号：US803134

    申请日：1997-02-18

    申请人： Milton David Goldenberg

    发明人： Milton David Goldenberg

    IPC分类号： A61K39/44 ,  A61K47/48 ,  A61K51/08 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K47/48423 ,  A61K39/44 ,  A61K2121/00

    摘要： Anticancer, antimicrobial and autoimmune disease, and anti-organ rejection therapy using cytotoxic agents is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced or drug-induced toxicity, especially to hematopoietic cells. Cytotoxic agents can include radioisotopes, drugs, toxins and even unconjugated cytotoxic antibodies. A preferred cytokine is IL-1. Higher doses of cytotoxic agents can be administered and tolerated by the patient and dose-limiting marrow toxicity can be prevented, palliated or reversed using adjunct cytokine therapy.

    摘要翻译： 使用细胞因子来预防，减轻或逆转不利的放射诱导或药物诱导的毒性，特别是造血细胞，改善抗癌，抗微生物和自身免疫性疾病以及使用细胞毒性剂的抗器官排斥治疗。 细胞毒剂可以包括放射性同位素，药物，毒素，甚至是非共轭的细胞毒性抗体。 优选的细胞因子是IL-1。 更高剂量的细胞毒性剂可以由患者施用和耐受，并且可以使用辅助细胞因子治疗来预防，缓解或逆转剂量限制性骨髓毒性。

    Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
    4.
    发明授权
    Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy 失效
    术中，血管内和内镜下肿瘤和病变检测，活检和治疗

    公开(公告)号：US6096289A

    公开(公告)日：2000-08-01

    申请号：US21392

    申请日：1998-02-10

    申请人： Milton David Goldenberg

    发明人： Milton David Goldenberg

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  A61K39/395 ,  C07K16/00

    CPC分类号： A61K49/0058 ,  A61K47/48753 ,  A61K49/0036 ,  A61K51/1048 ,  A61K51/1072 ,  A61K51/1093 ,  B82Y5/00 ,  A61K2121/00 ,  A61K2123/00

    摘要： Methods are provided for close-range intraoperative, endoscopic and intravascular deflection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions with photodynamic agents and methods of treating lesions with a protein conjugated to an agent capable of being activated to emit Auger electron or other ionizing radiation. Compositions and kits useful in the above methods are also provided.

    摘要翻译： 提供方法用于近距离术中，内镜和血管内的偏转和治疗病变，包括肿瘤和非恶性病变。 该方法使用用同位素和非同位素标记的抗体片段或亚片段。 还提供了用光动力学试剂检测和治疗病变的方法以及用能够被活化以发射俄歇电子或其他电离辐射的药物缀合的蛋白质处理病变的方法。 还提供了在上述方法中有用的组合物和试剂盒。

    Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy
    7.
    发明授权
    Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy 失效
    术中，血管内和内镜下肿瘤和病变检测，活检及治疗

    公开(公告)号：US06387350B2

    公开(公告)日：2002-05-14

    申请号：US09348818

    申请日：1999-07-08

    申请人： Milton David Goldenberg

    发明人： Milton David Goldenberg

    IPC分类号： A61K5100

    CPC分类号： A61K49/0058 ,  A61K47/6898 ,  A61K49/0036 ,  A61K51/1048 ,  A61K51/1072 ,  A61K51/1093 ,  A61K2121/00 ,  A61K2123/00 ,  B82Y5/00

    摘要： Methods are provided for close-range intraoperative, endoscopic and intravascular detection and treatment of lesions, including tumors and non-malignant lesions. The methods use antibody fragments or subfragments labeled with isotopic and non-isotopic agents. Also provided are methods for detection and treatment of lesions with photodynamic agents and methods of treating lesions with a protein conjugated to an agent capable of being activated to emit Auger electron or other ionizing radiation. Compositions and kits useful in the above methods are also provided.

    摘要翻译： 提供方法用于近距离术中，内窥镜和血管内检测和治疗病变，包括肿瘤和非恶性病变。 该方法使用用同位素和非同位素标记的抗体片段或亚片段。 还提供了用光动力学试剂检测和治疗病变的方法以及用能够被活化以发射俄歇电子或其他电离辐射的药物缀合的蛋白质处理病变的方法。 还提供了在上述方法中有用的组合物和试剂盒。

    Method and kit for imaging and treating organs and tissues
    8.
    发明授权
    Method and kit for imaging and treating organs and tissues 失效
    用于成像和治疗器官和组织的方法和试剂盒

    公开(公告)号：US06331175B1

    公开(公告)日：2001-12-18

    申请号：US09110181

    申请日：1998-07-06

    申请人： Milton David Goldenberg

    发明人： Milton David Goldenberg

    IPC分类号： A61M2500

    CPC分类号： G01R33/5601 ,  A61K49/16 ,  A61K51/10 ,  A61K51/1018 ,  A61K51/1036 ,  A61K51/1039 ,  A61K51/1045 ,  A61K51/1057 ,  A61K51/1072 ,  A61K2123/00 ,  B82Y5/00 ,  Y10S424/81 ,  Y10S530/868

    摘要： Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to above-mentioned tissue or organ, with an composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. The antibody/fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.

    摘要翻译： 提供了用于检测和治疗哺乳动物中正常，发育不全，异位或残余组织，器官或细胞的方法和组合物。 该方法包括在一个位点和通过提供进入上述组织或器官的途径的哺乳动物受试者肠胃外注射包含特异性结合靶向的器官，组织或细胞的抗体/片段的组合物。 抗体/片段可以单独施用，或者与成像，治疗，细胞保护或活化剂标记或缀合。