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    Treatment of infectious and inflammatory lesions
    1.
    发明授权
    Treatment of infectious and inflammatory lesions 失效
    治疗感染性和炎症性病变

    公开(公告)号：US5705158A

    公开(公告)日：1998-01-06

    申请号：US469992

    申请日：1995-06-06

    申请人： Hans John Hansen ,  Milton David Goldenberg

    发明人： Hans John Hansen ,  Milton David Goldenberg

    IPC分类号： A61K9/08 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/00 ,  A61K51/10 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P43/00 ,  C12P21/08 ,  C07K16/18

    CPC分类号： A61K47/48546 ,  A61K51/1018 ,  A61K2123/00 ,  Y10S530/866

    摘要： A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types. A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate. A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent. A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.

    摘要翻译： 用于靶向白细胞增生灶的多特异性抗白细胞抗体缀合物包含与至少一种成像剂缀合的至少两种不同的基本单特异性抗体或抗体片段的免疫反应性多特异性复合物，其中至少两种所述抗体或抗体片段特异性结合 到不同的白细胞类型。 用于将成像剂靶向炎性或感染性病变的方法包括以有效量肠胃外注射哺乳动物以靶向上述抗白细胞成像缀合物。 用于靶向白细胞增生灶的治疗性抗白细胞抗体 - 试剂缀合物包含与至少一种治疗性抗微生物剂缀合的至少一种特异性结合至少一种白细胞细胞类型的基本上单特异性抗体或抗体片段的免疫反应性活性基因。 治疗感染性病变的方法包括用有效量的胃肠外注射哺乳动物治疗上述抗白细胞治疗缀合物。

    Method for antibody targeting of therapeutic agents
    3.
    发明授权
    Method for antibody targeting of therapeutic agents 失效
    治疗剂抗体靶向的方法

    公开(公告)号：US5851527A

    公开(公告)日：1998-12-22

    申请号：US445110

    申请日：1995-05-19

    申请人： Hans John Hansen

    发明人： Hans John Hansen

    IPC分类号： A61K47/48 ,  A61K39/395

    CPC分类号： B82Y5/00 ,  A61K47/48761

    摘要： The targeting capability of an antibody is enhanced using an antibody-enzyme conjugate and a separate soluble substrate-agent conjugate, wherein the targeted enzyme catalyzes the conversion of a soluble substrate, bearing at least one therapeutic or diagnostic agent, to a product comprising the agent, which accumulates at the target site for effective treatment or diagnosis. This method is useful for targeting any type of agent to a site to which an antibody can selectively bind, including use for imaging, e.g., tumors, infectious lesions, fibrin clots, myocardial infarctions, non-cancerous cells, damaged normal cells, atherosclerotic plaque, lymphocyte autoreactive clones, and for therapy, e.g., with drugs, toxins, immune modulators, radioisotopes or antibiotics.

    摘要翻译： 使用抗体 - 酶缀合物和单独的可溶性底物 - 试剂缀合物增强抗体的靶向能力，其中靶向酶催化具有至少一种治疗剂或诊断剂的可溶性底物转化成包含该试剂的产品 ，其累积在目标部位以进行有效的治疗或诊断。 该方法可用于将任何类型的试剂靶向抗体可选择性结合的位点，包括用于成像的用途，例如肿瘤，感染性病变，纤维蛋白凝块，心肌梗塞，非癌细胞，损伤的正常细胞，动脉粥样硬化斑块 ，淋巴细胞自身反应性克隆，以及用于治疗，例如用药物，毒素，免疫调节剂，放射性同位素或抗生素。