公开(公告)号：US20160169781A1

公开(公告)日：2016-06-16

申请号：US14565597

申请日：2014-12-10

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Kenji TAKAI ,  Katsuya ENDOU ,  Takahiro SUZUKI ,  Satomi YAGI ,  Hideki ITAYA

IPC: G01N1/40

CPC classification number: G01N1/4077 ,  G01N2001/4088

Abstract: A cell-trapping system according to one embodiment of the present invention is a cell-trapping system which traps specific cells in blood by passing the blood from a first principal surface side of a filter with a plurality of through-holes formed across a thickness of a sheet toward a second principal surface side opposed to the first principal surface, wherein a linear velocity of the blood at a point in time when the blood passes through the filter is 1 cm/min to 40 cm/min, an aperture ratio of the filter is 3% to 10%, the plurality of through-holes disposed in the filter each have a rectangular shape or a rounded-corner rectangular shape, and a mean of minor pore diameters of the plurality of through-holes on the first principal surface side is 7.0 μm to 10.0 μm.

Abstract translation: 根据本发明的一个实施方案的细胞捕获系统是通过使来自过滤器的第一主表面侧的血液通过跨过多个通孔形成的多个通孔来捕集血液中的特定细胞的细胞捕获系统 与第一主面相对的第二主面侧的片材，其中血液通过过滤器的时间点的血液的线速度为1cm / min〜40cm / min，孔径比为 过滤器为3％至10％，设置在过滤器中的多个通孔均具有矩形或圆角矩形形状，并且第一主表面上的多个通孔的小孔径平均值 侧为7.0μm〜10.0μm。

公开(公告)号：US20170247662A1

公开(公告)日：2017-08-31

申请号：US15465638

申请日：2017-03-22

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Hisashige KANBARA ,  Yoshihito KIKUHARA ,  Takahiro SUZUKI

IPC: C12N5/09 ,  G03F7/038 ,  G03F7/20 ,  G03F7/32 ,  B01D39/10 ,  G03F7/42 ,  C08J5/12 ,  G01N33/49 ,  G01N1/40 ,  G03F7/039 ,  G03F7/40

CPC classification number: C12N5/0694 ,  B01D39/10 ,  B22D25/02 ,  B22D29/00 ,  C08J5/121 ,  C08J2300/12 ,  G01N1/4077 ,  G01N33/49 ,  G01N2001/4088 ,  G03F7/038 ,  G03F7/039 ,  G03F7/2004 ,  G03F7/322 ,  G03F7/405 ,  G03F7/428 ,  Y10T29/49 ,  Y10T156/10

Abstract: Provided are a cancer cell-trapping metal filter which has a high opening ratio, a cancer cell-trapping metal filter sheet, a cancer cell-trapping device using the cancer cell-trapping filter, and manufacturing methods therefor.According to a cancer cell-trapping metal filter 1, openings of connected through-holes 12 that are formed in a metal sheet 11 have a wave shape, and thus it is possible to extract a CTC from other components by utilizing a hole diameter on a short-side side of the openings, and it is possible to make the connected through-holes be closer to each other due to the wave shape while maintaining a CTC trapping ability. Accordingly, it is possible to further improve the opening ratio in the cancer cell-trapping metal filter 1.

公开(公告)号：US20170128858A1

公开(公告)日：2017-05-11

申请号：US15409747

申请日：2017-01-19

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Takahiro SUZUKI ,  Hisashige KANBARA ,  Yoshihito KIKUHARA ,  Kyosuke SUZUKI

IPC: B01D29/01 ,  G03F7/00 ,  A61M1/36 ,  C25D1/08

CPC classification number: B01D29/012 ,  A61M1/36 ,  A61M2207/00 ,  C25D1/00 ,  C25D1/08 ,  C25D3/12 ,  G03F7/0015

Abstract: A metal filter includes a plurality of through holes. An opening shape of each of the plurality of through holes is a rectangle or rounded-rectangle and a length of a short side of the rectangle or a rounded rectangle is 5 to 15 μm. A method for concentrating cancer cells using the metal filter includes separating cancer cells from blood and blood cell constituents by passing blood, red blood cells, white blood cells, and platelets through the plurality of through holes while capturing cancer cells to concentrate the cancer cells.

公开(公告)号：US20140299539A1

公开(公告)日：2014-10-09

申请号：US14228298

申请日：2014-03-28

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Kenji TAKAI ,  Satomi YAGI ,  Takahiro SUZUKI ,  Yoshinori EJIRI ,  Hiroshi YAMAMOTO ,  Akio TAKAHASHI

IPC: B01D39/10

CPC classification number: B01D39/10 ,  B01D2239/0478

Abstract: A biomolecule capturing filter, comprising a gold plating on the surface of a biomolecule capturing filter made of a metal other than gold, the gold plating being electroless gold plating is disclosed.

Abstract translation: 公开了一种生物分子捕获过滤器，其包括由金以外的金属制成的生物分子捕获过滤器的表面上的镀金，镀金是无电镀金。

公开(公告)号：US20150316457A1

公开(公告)日：2015-11-05

申请号：US14651245

申请日：2013-12-11

Applicant: HITACHI CHEMICAL COMPANY, LTD.

Inventor： Hisashige KANBARA ,  Takahiro SUZUKI ,  Yoshihito KIKUHARA ,  Masafumi KANETOMO

IPC: G01N1/40 ,  G06K9/00

CPC classification number: C12M47/04 ,  G01N1/4077 ,  G01N2001/4088 ,  G06K9/00134 ,  G06T7/0012 ,  G06T7/10 ,  G06T2207/30004

Abstract: Disclosed is to isolate cancer cells trapped on a filter without any damage.In a cancer cell isolation device (1), cancer cells X trapped on a filter (100) are captured by a camera (30) as an image capturing unit, and the cancer cells X are carried one by one by using a handling unit (40) while the filter (100) and a storage container (200) are moved by an X-axis movement stand (14), a Y-axis movement stand (16), and a Z-axis movement stand (18) as movement units while the captured image is output from an output unit (32). Accordingly, it is possible to isolate the cancer cells on the filter without damaging the cancer cells and hence to appropriately perform an observation or the like.

Abstract translation: 公开了分离被捕获在过滤器上的癌细胞而没有任何损害。 在癌细胞分离装置（1）中，捕获在过滤器（100）上的癌细胞X被摄像机（30）拍摄为图像拍摄部，并且通过使用处理单元逐个携带癌细胞X. 40），通过X轴运动支架（14），Y轴运动支架（16）和Z轴运动支架（18）作为运动移动过滤器（100）和存储容器（200） 单元，同时从输出单元（32）输出捕获的图像。 因此，可以在不损害癌细胞的情况下分离过滤器上的癌细胞，从而适当地进行观察等。