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    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD
    1.
    发明申请
    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 有权

    公开(公告)号：US20220205913A1

    公开(公告)日：2022-06-30

    申请号：US17699834

    申请日：2022-03-21

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Norikazu SUGIYAMA ,  Masanori MATSUBARA ,  Satoshi YAMAMOTO

    IPC: G01N21/64

    Abstract: A sample observation device includes a sample container that holds the sample stained with a first fluorescent substance and a solution including a second fluorescent substance, an irradiation unit that performs irradiation with first excitation light and second excitation light, a scanning unit that scans the sample container in one direction, an image formation unit that forms first fluorescent light from the sample and second fluorescent light from the solution, an imaging unit that outputs first image data based on the first fluorescent light and first image data based on the second fluorescent light, an image processing unit that generates a first fluorescent light image based on a plurality of pieces of first image data and a second fluorescent light image based on a plurality of pieces of second image data, and an analysis unit that specifies an area in which there is the sample on the basis of the second fluorescent light image and sets an analysis area in the first fluorescent light image.

    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD
    3.
    发明申请
    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 有权

    公开(公告)号：US20220034811A1

    公开(公告)日：2022-02-03

    申请号：US17488659

    申请日：2021-09-29

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Norikazu SUGIYAMA ,  Masanori MATSUBARA ,  Satoshi YAMAMOTO

    IPC: G01N21/64 ,  G01N21/51

    Abstract: A sample observation device includes an irradiation unit that irradiates a sample with planar light, a scanning unit that scans the sample in one direction with respect to an irradiation surface of the planar light, an image formation unit that forms images of fluorescent light and scattered light from the sample, an imaging unit that outputs first image data based on a light image of the fluorescent light and second image data based on a light image of the scattered light, an image processing unit that generates a fluorescent light image on the basis of a plurality of pieces of first image data and generates a scattered light image on the basis of a plurality of pieces of second image data, and an analysis unit that specifies an area in which there is the sample in the fluorescent light image on the basis of the scattered light image, and sets an analysis area in the fluorescent light image on the basis of the area in which there is the sample.

    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD
    5.
    发明申请
    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 有权

    公开(公告)号：US20210382286A1

    公开(公告)日：2021-12-09

    申请号：US17411533

    申请日：2021-08-25

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Satoshi YAMAMOTO ,  Masanori MATSUBARA ,  Norikazu SUGIYAMA

    IPC: G02B21/00 ,  G02B21/36

    Abstract: A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).

    AGGREGATED CELL EVALUATION METHOD AND AGGREGATED CELL EVALUATION DEVICE
    7.
    发明申请
    AGGREGATED CELL EVALUATION METHOD AND AGGREGATED CELL EVALUATION DEVICE 有权
    聚集细胞评估方法和聚集细胞评估装置

    公开(公告)号：US20150369790A1

    公开(公告)日：2015-12-24

    申请号：US14766238

    申请日：2014-02-05

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Hidenao IWAI ,  Takuji KATAOKA ,  Satoshi YAMAMOTO ,  Norikazu SUGIYAMA ,  Toyohiko YAMAUCHI ,  Kentaro GOTO

    IPC: G01N33/483 ,  G01N21/47

    CPC classification number: G01N33/4833 ,  G01B11/00 ,  G01N21/47 ,  G01N21/49 ,  G01N2021/4707 ,  G01N2021/479

    Abstract: An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value Kn of a speckle image In at each time tn, determines a maximum value Kmax among the speckle contrast values K1 to KN, and normalizes the speckle contrast value Kn at each time tn by the maximum value Kmax to obtain a normalized speckle contrast value Kn′. The evaluation unit evaluates motion of the aggregated cells, based on the normalized speckle contrast value Kn′ at each time tn.

    Abstract translation: 聚合单元评估装置包括激光光源，散斑图像获取单元，SC计算单元，评估单元和存储单元。 斑点图像获取单元通过从激光光源输出的激光照射聚集单元，在聚集单元中产生的前向散射光获取二维散斑图像。 SC计算单元计算每次tn时的散斑图像In的散斑对比度值Kn，确定散斑对比度值K 1〜K N的最大值Kmax，并将每个时间tn处的散斑对比度值Kn标准化最大值Kmax 以获得归一化散斑对比度值Kn'。 评估单元基于每个时刻tn处的归一化散斑对比度值Kn'评估聚集单元的运动。

    METHOD FOR OBSERVING STEM CELLS, METHOD FOR REMOVAL OF CELL REGION IN STATE TENDING TOWARD DIFFERENTIATION, AND DEVICE FOR OBSERVING STEM CELLS
    8.
    发明申请
    METHOD FOR OBSERVING STEM CELLS, METHOD FOR REMOVAL OF CELL REGION IN STATE TENDING TOWARD DIFFERENTIATION, AND DEVICE FOR OBSERVING STEM CELLS 有权
    用于观察干细胞的方法，用于移除状态趋势分化中的细胞区域的方法，以及用于观察干细胞的装置

    公开(公告)号：US20150323454A1

    公开(公告)日：2015-11-12

    申请号：US14806999

    申请日：2015-07-23

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Norikazu SUGIYAMA ,  Takuji KATAOKA ,  Ikuo ARATA

    IPC: G01N21/47 ,  G01N33/483

    CPC classification number: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  G01N33/4833 ,  G01N33/5005 ,  G01N2201/0446 ,  G01N2201/062 ,  G02B21/088 ,  G02B21/36

    Abstract: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem cells C in the petri dish 11 via the water 13, and detecting scattered light L2, the scattered light L2 being the illumination light L1 emitted to the stem cells C that is scattered by the stem cells C and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light L2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation.

    Abstract translation: 通过观察装置1观察干细胞的方法包括：将干细胞C放置在培养皿11中，通过水13将培养皿11安装在波导21上，将照明光L1发射到波导21中并发射照明光L1 通过水13向陪替氏培养皿11中的干细胞C，并且检测散射光L2，散射光L2是发射到干细胞C的干细胞C的照射光L1，其被干细胞C散射并已经通过波导 然后，在通过散射光L2检测到的光图像中，比其他区域明显更暗的区域被识别为处于朝向微分的状态。

    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD
    9.
    发明申请
    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 有权

    公开(公告)号：US20220283420A1

    公开(公告)日：2022-09-08

    申请号：US17751818

    申请日：2022-05-24

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Satoshi YAMAMOTO ,  Masanori MATSUBARA ,  Norikazu SUGIYAMA

    IPC: G02B21/00 ,  G02B21/36

    Abstract: A sample observation device (1) includes: an emission optical system (3) for emitting planar light (L2) onto a sample (S); a scanning unit (4) for scanning the sample (S) with respect to an emission face (R) of the planar light (L2); an imaging optical system (5) having an observation axis (P2) inclined with respect to the emission face (R) and for forming an image from observation light (L3) generated in the sample (S) in accordance with the emission of the planar light (L2); an image acquiring unit (6) for acquiring a plurality of partial image data corresponding to a part of an optical image according to the observation light (L3) formed as an image by the imaging optical system (5); and an image generating unit (8) for generating observation image data of the sample S based on the plurality of partial image data generated by the image acquiring unit (6).

    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD
    10.
    发明申请
    SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 有权

    公开(公告)号：US20210116373A1

    公开(公告)日：2021-04-22

    申请号：US16629326

    申请日：2018-04-10

    Applicant: HAMAMATSU PHOTONICS K.K.

    Inventor： Norikazu SUGIYAMA ,  Masanori MATSUBARA ,  Satoshi YAMAMOTO

    IPC: G01N21/64 ,  G06T7/00 ,  G01N21/51 ,  G01N1/30 ,  G01N1/31 ,  C12Q1/06

    Abstract: A sample observation device includes an imaging unit that images observation light generated due to irradiation with the planar light that is transmitted through a membrane filter and outputs fluorescent light image data, a partial image generation unit that specifies a first area corresponding to a first sample holding space and a second area corresponding to a second sample holding space in the fluorescent light image data, and generates first partial image data corresponding to the first area and second partial image data corresponding to the second area, an observation image generation unit that generates first observation image data and second observation image data on the basis of the partial image data, and an analysis unit that analyzes a sample on the basis of the first observation image data and the second observation image data.

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