公开(公告)号：US20150050275A1

公开(公告)日：2015-02-19

申请号：US14511673

申请日：2014-10-10

Applicant: GENENTECH, INC.

Inventor： Marc Wong ,  Jerome Joseph Bill, JR. ,  Arick Michael Brown ,  Glen Scott Giese ,  Judy Fay-Chen Hsii ,  Amy Lim ,  Josefine Persson ,  Asha Nandini Radhamohan ,  Maricel Rodriguez

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2863 ,  A61K39/39558 ,  A61K45/06 ,  C07K1/14 ,  C07K1/18 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  C07K16/065 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/56

Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.

Abstract translation: 本文提供了纯化抗c-met抗体的方法，包含纯化的抗c-met抗体的组合物和药物制剂及其使用方法。

公开(公告)号：US10073098B2

公开(公告)日：2018-09-11

申请号：US15061943

申请日：2016-03-04

Applicant: Genentech, Inc.

Inventor： Marc Wong ,  Liliana T. Yee ,  Amy Lim ,  Chris B. Fong

IPC: G01N33/53 ,  G01N33/573 ,  C12N9/02 ,  C12N9/90 ,  C07K1/22 ,  C07K16/40 ,  A61K38/00

Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.

公开(公告)号：US20130129718A1

公开(公告)日：2013-05-23

申请号：US13681980

申请日：2012-11-20

Applicant: Genentech, Inc.

Inventor： Marc Wong ,  Jerome Joseph Bill, JR. ,  Arick Michael Brown ,  Glen Scott Giese ,  Judy Fay-Chen Hsii ,  Amy Lim ,  Josefine Persson ,  Asha Nandini Radhamohan ,  Maricel Rodriguez

IPC: C07K1/14 ,  C07K1/22 ,  A61K45/06 ,  C07K1/34 ,  A61K39/395 ,  C07K1/18 ,  C07K16/32 ,  C07K1/36

CPC classification number: C07K16/2863 ,  A61K39/39558 ,  A61K45/06 ,  C07K1/14 ,  C07K1/18 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  C07K16/065 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/56

Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.

公开(公告)号：US20220169675A1

公开(公告)日：2022-06-02

申请号：US17328408

申请日：2021-05-24

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Paul MCDONALD ,  Richard ST. JOHN ,  Marc Wong ,  Roberto FALKENSTEIN ,  Wolfgang KOEHNLEIN ,  Klaus SCHWENDNER ,  Bernhard SPENSBERGER ,  Michael WIEDMANN ,  Frank ZETTL ,  Annika KLEINJANS ,  Carina KOPP ,  Benjamin TRAN ,  Ryan ERICKSON

IPC: C07K1/22 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/36

Abstract: The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.

公开(公告)号：US10690671B2

公开(公告)日：2020-06-23

申请号：US16044360

申请日：2018-07-24

Applicant: Genentech, Inc.

Inventor： Marc Wong ,  Liliana T. Yee ,  Amy Lim ,  Chris B. Fong

IPC: G01N33/53 ,  G01N33/573 ,  C12N9/02 ,  C12N9/90 ,  C07K1/22 ,  C07K16/40 ,  A61K38/00

Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.

公开(公告)号：US20190056399A1

公开(公告)日：2019-02-21

申请号：US16044360

申请日：2018-07-24

Applicant: Genentech, Inc.

Inventor： Marc Wong ,  Liliana T. Yee ,  Amy Lim ,  Chris B. Fong

IPC: G01N33/573 ,  C12N9/90 ,  C07K1/22 ,  C07K16/40 ,  C12N9/02 ,  A61K38/00

Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.