-
公开(公告)号：US10690671B2
公开(公告)日：2020-06-23
申请号：US16044360
申请日：2018-07-24
Applicant: Genentech, Inc.
Inventor： Marc Wong , Liliana T. Yee , Amy Lim , Chris B. Fong
Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
-
公开(公告)号：US20190056399A1
公开(公告)日：2019-02-21
申请号：US16044360
申请日：2018-07-24
Applicant: Genentech, Inc.
Inventor： Marc Wong , Liliana T. Yee , Amy Lim , Chris B. Fong
Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
-
公开(公告)号：US09862778B2
公开(公告)日：2018-01-09
申请号：US14251428
申请日：2014-04-11
Applicant: Genentech, Inc.
Inventor： Glen Giese , Amy Lim , Josefine Persson , Justin Scheer , Ambrose Williams
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622
Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
-
Patent Agency Ranking
公开(公告)号：US20150050275A1
公开(公告)日：2015-02-19
申请号：US14511673
申请日：2014-10-10
Applicant: GENENTECH, INC.
Inventor： Marc Wong , Jerome Joseph Bill, JR. , Arick Michael Brown , Glen Scott Giese , Judy Fay-Chen Hsii , Amy Lim , Josefine Persson , Asha Nandini Radhamohan , Maricel Rodriguez
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2863 , A61K39/39558 , A61K45/06 , C07K1/14 , C07K1/18 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/065 , C07K16/32 , C07K2317/24 , C07K2317/56
Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.
Abstract translation: 本文提供了纯化抗c-met抗体的方法，包含纯化的抗c-met抗体的组合物和药物制剂及其使用方法。
-
公开(公告)号：US11725065B2
公开(公告)日：2023-08-15
申请号：US16820660
申请日：2020-03-16
Applicant: Genentech, Inc.
Inventor： Glen Giese , Amy Lim , Josefine Persson , Justin Scheer , Ambrose Williams
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622
Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
-
公开(公告)号：US20220203347A1
公开(公告)日：2022-06-30
申请号：US17542138
申请日：2021-12-03
Applicant: Genentech, Inc.
Inventor： Marc L. Wong , Donna F. Quicho , Jason A. Brown , Josefine K. Persson , Amy Lim
IPC: B01J49/53 , B01J41/20 , B01J49/07 , B01J49/57 , C07K1/18 , B01J49/06 , B01J39/26 , B01D15/36 , B01D15/20 , B01D15/42 , B01D15/38
Abstract: The present invention provides methods for cleaning or regenerating a chromatography material for reuse. The methods of the invention can be used for cleaning or regenerating ion exchange chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products where the ion exchange chromatography column in used in overload mode.
-
公开(公告)号：US10073098B2
公开(公告)日：2018-09-11
申请号：US15061943
申请日：2016-03-04
Applicant: Genentech, Inc.
Inventor： Marc Wong , Liliana T. Yee , Amy Lim , Chris B. Fong
Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
-
公开(公告)号：US20130129718A1
公开(公告)日：2013-05-23
申请号：US13681980
申请日：2012-11-20
Applicant: Genentech, Inc.
Inventor： Marc Wong , Jerome Joseph Bill, JR. , Arick Michael Brown , Glen Scott Giese , Judy Fay-Chen Hsii , Amy Lim , Josefine Persson , Asha Nandini Radhamohan , Maricel Rodriguez
CPC classification number: C07K16/2863 , A61K39/39558 , A61K45/06 , C07K1/14 , C07K1/18 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/065 , C07K16/32 , C07K2317/24 , C07K2317/56
Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.021 seconds)
