公开(公告)号：US20220203347A1

公开(公告)日：2022-06-30

申请号：US17542138

申请日：2021-12-03

Applicant: Genentech, Inc.

Inventor： Marc L. Wong ,  Donna F. Quicho ,  Jason A. Brown ,  Josefine K. Persson ,  Amy Lim

IPC: B01J49/53 ,  B01J41/20 ,  B01J49/07 ,  B01J49/57 ,  C07K1/18 ,  B01J49/06 ,  B01J39/26 ,  B01D15/36 ,  B01D15/20 ,  B01D15/42 ,  B01D15/38

Abstract: The present invention provides methods for cleaning or regenerating a chromatography material for reuse. The methods of the invention can be used for cleaning or regenerating ion exchange chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products where the ion exchange chromatography column in used in overload mode.