Invention Application
- Patent Title: Method for the reduction of host cell proteins in affinity chromatography
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Application No.: US17328408Application Date: 2021-05-24
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Publication No.: US20220169675A1Publication Date: 2022-06-02
- Inventor: Paul MCDONALD , Richard ST. JOHN , Marc Wong , Roberto FALKENSTEIN , Wolfgang KOEHNLEIN , Klaus SCHWENDNER , Bernhard SPENSBERGER , Michael WIEDMANN , Frank ZETTL , Annika KLEINJANS , Carina KOPP , Benjamin TRAN , Ryan ERICKSON
- Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
- Applicant Address: US CA South San Francisco; US NJ Little Falls
- Assignee: Genentech, Inc.,Hoffmann-La Roche Inc.
- Current Assignee: Genentech, Inc.,Hoffmann-La Roche Inc.
- Current Assignee Address: US CA South San Francisco; US NJ Little Falls
- Main IPC: C07K1/22
- IPC: C07K1/22 ; C07K16/22 ; C07K16/18 ; C07K16/28 ; C07K16/32 ; C07K16/36
Abstract:
The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.
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