公开(公告)号：US20220169675A1

公开(公告)日：2022-06-02

申请号：US17328408

申请日：2021-05-24

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Paul MCDONALD ,  Richard ST. JOHN ,  Marc Wong ,  Roberto FALKENSTEIN ,  Wolfgang KOEHNLEIN ,  Klaus SCHWENDNER ,  Bernhard SPENSBERGER ,  Michael WIEDMANN ,  Frank ZETTL ,  Annika KLEINJANS ,  Carina KOPP ,  Benjamin TRAN ,  Ryan ERICKSON

IPC: C07K1/22 ,  C07K16/22 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/36

Abstract: The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.

公开(公告)号：US20180186832A1

公开(公告)日：2018-07-05

申请号：US15900461

申请日：2018-02-20

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Paul MCDONALD ,  Richard ST. JOHN ,  Marc WONG ,  Roberto FALKENSTEIN ,  Wolfgang KOEHNLEIN ,  Klaus SCHWENDNER ,  Bernhard SPENSBERGER ,  Michael WIEDMANN ,  Frank ZETTL ,  Annika KLEINJANS ,  Carina KOPP ,  Benjamin TRAN ,  Ryan ERICKSON

IPC: C07K1/22 ,  C07K16/28 ,  C07K16/18 ,  C07K16/32 ,  C07K16/22 ,  C07K16/36

CPC classification number: C07K1/22 ,  C07K16/18 ,  C07K16/22 ,  C07K16/2854 ,  C07K16/32 ,  C07K16/36 ,  C07K2317/14 ,  C07K2317/31

Abstract: The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.