公开(公告)号：US10913742B2

公开(公告)日：2021-02-09

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Daniel Shore ,  Elisia Villemure ,  Matthew Volgraf ,  Baihua Hu ,  Aijun Lu ,  Andrew Cridland ,  Stuart Ward ,  Francis Beaumier ,  Martin Dery ,  Robin Larouche-Gauthier

IPC: C07D487/04 ,  C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  A61K31/519 ,  A61P11/06 ,  C07D498/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US09988400B2

公开(公告)日：2018-06-05

申请号：US15094687

申请日：2016-04-08

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/04 ,  C07D513/10 ,  C07D513/14 ,  C07D519/00

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20160222033A1

公开(公告)日：2016-08-04

申请号：US15094687

申请日：2016-04-08

Applicant: Genentech, Inc.

Inventor： Jiang Yu ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Volgraf Matthew

IPC: C07D513/14 ,  C07D513/10 ,  C07D519/00 ,  C07D513/04

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Abstract translation: 本发明涉及某些噻唑并嘧啶酮化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。

公开(公告)号：US12202824B2

公开(公告)日：2025-01-21

申请号：US17816855

申请日：2022-08-02

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: C07D413/14 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53 ,  A61P11/00 ,  A61P19/02 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/08 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20240368186A1

公开(公告)日：2024-11-07

申请号：US18676200

申请日：2024-05-28

Applicant: Genentech, Inc.

Inventor： Matthew Leo Landry ,  Christian Nilewski ,  Michael Siu ,  Elisia Villemure ,  Yong Wang ,  BinQing Wei ,  Melissa Ann Ashley ,  Steven Do ,  Lewis John Gazzard ,  Samantha Alyson Green

IPC: C07D498/22 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  C07D519/00

Abstract: Provided herein are aza-tetracyclic oxazepinyl compounds useful in the treatment of cancers.

公开(公告)号：US10647731B2

公开(公告)日：2020-05-12

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US12006331B2

公开(公告)日：2024-06-11

申请号：US17862963

申请日：2022-07-12

Applicant: GENENTECH, INC.

Inventor： Samantha Alyson Green ,  Jessica Marie Grandner ,  Steven Thomas Staben ,  Neri Amara ,  Vishva M. Dixit ,  Elisia Villemure

IPC: C07D498/04 ,  A61K9/08 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D498/04 ,  A61K9/08 ,  A61K9/12 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides a compound of formula (I):




or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 have any of the values described in the specification, as well as compositions comprising a compound of formula (I) or a prodrug thereof, or a pharmaceutically acceptable salt thereof. The compounds are agonists of glycolytic enzyme phosphofructokinase-1 liver type and are useful for treating diseases associated with the activity of glycolytic enzyme phosphofructokinase-1 liver type, such as cancer, diabetes, sepsis, and septic shock.

公开(公告)号：US20200308161A1

公开(公告)日：2020-10-01

申请号：US16903020

申请日：2020-06-16

Applicant: Genentech, Inc.

Inventor： Jack Alexander Terrett ,  Huifen Chen ,  Lea Constantineau-Forget ,  Robin Larouche-Gauthier ,  Luce Lépissier ,  Francis Beaumier ,  Martin Déry ,  Chantal Grand-Maître ,  Claudio Sturino ,  Matthew Volgraf ,  Elisia Villemure

IPC: C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  C07D498/04 ,  A61K31/427 ,  A61P23/00 ,  A61P11/00

Abstract: The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US10711004B2

公开(公告)日：2020-07-14

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Brian Safina ,  Daniel Shore ,  Jack Terrett ,  Elisia Villemure ,  Matthew Volgraf ,  Stuart Ward ,  Aijun Lu ,  Robin Larouche-Gauthier ,  Francis Beaumier ,  Martin Dery ,  Lea Constantineau-Forget ,  Chantal Grand-Maitre ,  Luce Lepissier

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20180244694A1

公开(公告)日：2018-08-30

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D519/00 ,  C07D513/04 ,  C07D513/10

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.