-
公开(公告)号：US11279735B2
公开(公告)日：2022-03-22
申请号：US16816969
申请日：2020-03-12
Applicant: Genentech, Inc.
Inventor： Emily J. Hanan , Georgette Castanedo , Marie Gabrielle Braun , Keira Garland , Peter Andrew Smith , Richard Pastor , Paul Gibbons , Yunxing Cheng , Guosheng Wu , Yuhong Fu , Po-Wai Yuen
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US11155557B2
公开(公告)日：2021-10-26
申请号：US16452058
申请日：2019-06-25
Applicant: Genentech, Inc.
Inventor： F. Anthony Romero , Mark Zak , Guiling Zhao , Paul Gibbons , Wei Li , Yun-Xing Cheng , Po-Wai Yuen , Limin Cheng
IPC: C07D487/04 , C07D498/10
Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.
-
公开(公告)号：US20180291000A1
公开(公告)日：2018-10-11
申请号：US16008378
申请日：2018-06-14
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC: C07D401/12 , C07C317/42 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D213/84 , C07D213/81 , C07D213/75 , C07D213/74 , C07D213/54 , C07D213/40
CPC classification number: C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
-
公开(公告)号：US20230346753A1
公开(公告)日：2023-11-02
申请号：US18073768
申请日：2022-12-02
Applicant: Valo Health, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC: A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
CPC classification number: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
-
公开(公告)号：US20210244717A1
公开(公告)日：2021-08-12
申请号：US17018196
申请日：2020-09-11
Applicant: Valo Early Discovery, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC: A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
-
公开(公告)号：US10647695B2
公开(公告)日：2020-05-12
申请号：US16419333
申请日：2019-05-22
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC: C07D401/12 , C07D471/04 , C07D213/75 , C07D213/40 , C07D213/81 , C07C317/42 , C07D213/54 , C07D213/74 , C07D213/84 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
-
7.发明申请5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 有权5-氯二-2-二氟甲基苯基吡唑啉酮化合物，组合物及其使用方法
公开(公告)号：US20150336962A1
公开(公告)日：2015-11-26
申请号：US14720323
申请日：2015-05-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wai Yuen
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。
-
公开(公告)号：US11485745B2
公开(公告)日：2022-11-01
申请号：US16944581
申请日：2020-07-31
Applicant: Valo Health, Inc. , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng
IPC: C07D519/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D491/048 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513
Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
-
公开(公告)号：US20190388405A1
公开(公告)日：2019-12-26
申请号：US16538208
申请日：2019-08-12
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC: A61K31/4355 , C07D491/048 , C07D487/04 , A61K45/06 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/437 , A61K31/4365 , C07D495/04 , C07D491/04 , C07D471/04
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
-
公开(公告)号：US10329275B2
公开(公告)日：2019-06-25
申请号：US16008378
申请日：2018-06-14
Applicant: Forma TM, LLC , Genentech, Inc.
Inventor： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC: C07D401/12 , C07D471/04 , C07D213/54 , C07D213/75 , C07D213/81 , C07C317/42 , C07D213/74 , C07D213/84 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40
Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
