专利检索 ap:("Valo Health, Inc." OR "Genentech, Inc.") AND inv:"Kenneth W. Bair" 第 1 页

1.

发明公开
NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT 审中-公开

公开(公告)号：US20230346753A1

公开(公告)日：2023-11-02

申请号：US18073768

申请日：2022-12-02

申请人： Valo Health, Inc. , Genentech, Inc.

发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng

IPC分类号： A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048

CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04

摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

2.

发明授权
Compounds and compositions for the inhibition of NAMPT 有权

公开(公告)号：US11547701B2

公开(公告)日：2023-01-10

申请号：US17018196

申请日：2020-09-11

申请人： Valo Health, Inc. , Genentech, Inc.

发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng

IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048

摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

3.

发明授权
Compounds and compositions for the inhibition of NAMPT 有权

公开(公告)号：US11279687B2

公开(公告)日：2022-03-22

申请号：US16824885

申请日：2020-03-20

申请人： Valo Health, Inc. , Genentech, Inc.

发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen

IPC分类号： C07D401/12 , C07D213/74 , C07D213/75 , C07D213/81 , A61K31/4406 , C07C317/42 , C07D213/54 , C07D213/84 , C07D471/04 , A61K31/437 , A61K31/44 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40

摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

4.

发明授权
Amido spirocyclic amide and sulfonamide derivatives 有权

公开(公告)号：US11485745B2

公开(公告)日：2022-11-01

申请号：US16944581

申请日：2020-07-31

申请人： Valo Health, Inc. , Genentech, Inc.

发明人： Kenneth W. Bair , Timm R. Baumeister , Peter Dragovich , Xiongcai Liu , Snahel Patel , Po-Wai Yuen , Mark Zak , Guiling Zhao , Yamin Zhang , Xiaozhang Zheng

IPC分类号： C07D519/00 , C07D495/04 , C07D471/04 , C07D487/04 , C07D491/048 , A61K31/438 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/513

摘要： Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

5.

发明授权
3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US11891365B2

公开(公告)日：2024-02-06

申请号：US17238321

申请日：2021-04-23

申请人： Valo Health, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair , David S. Millan , Matthew W. Martin

IPC分类号： A61K31/5513 , C07D267/14 , C07D291/08 , C07D413/06 , C07D419/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

CPC分类号： C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:

where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

6.

发明授权
3-alkyl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US11279681B2

公开(公告)日：2022-03-22

申请号：US17031814

申请日：2020-09-24

申请人： Valo Health, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , David S. Millan , Matthew W. Martin , Kenneth W. Bair

IPC分类号： A61K31/55 , A61K31/554 , C07D223/16 , C07D281/02 , C07D281/10 , C07D471/04 , C07D513/04 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

7.

发明授权
[6,6] fused bicyclic HDAC8 inhibitors 有权

公开(公告)号：US11414392B2

公开(公告)日：2022-08-16

申请号：US17066385

申请日：2020-10-08

申请人： Valo Health, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Jennifer R. Thomason , Mary-Margaret Zablocki , Bingsong Han , Nicholas Barczak , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair

IPC分类号： C07D265/36 , C07D413/12 , C07D413/06 , C07D401/04 , C07D279/16 , C07D491/107 , C07D413/10 , C07D471/04 , C07D417/06 , C07D513/04 , C07D487/04 , C07D265/34 , C07D279/14

摘要： The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

8.

发明公开
[6,6] FUSED BICYCLIC HDAC8 INHIBITORS 审中-公开

公开(公告)号：US20230406830A1

公开(公告)日：2023-12-21

申请号：US18096712

申请日：2023-01-13

申请人： Valo Health, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Jennifer R. Downing , Mary-Margaret Zablocki , Bingsong Han , Nicholas Barczak , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , Kenneth W. Bair

IPC分类号： C07D265/36 , C07D413/12 , C07D413/06 , C07D401/04 , C07D279/16 , C07D491/107 , C07D413/10 , C07D471/04 , C07D417/06 , C07D513/04 , C07D487/04 , C07D265/34 , C07D279/14

CPC分类号： C07D265/36 , C07D413/12 , C07D413/06 , C07D401/04 , C07D279/16 , C07D491/107 , C07D413/10 , C07D471/04 , C07D417/06 , C07D513/04 , C07D487/04 , C07D265/34 , C07D279/14

摘要： The present invention is directed to compounds of Formula I:

and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

9.

发明授权
Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) 有权

公开(公告)号：US11479564B2

公开(公告)日：2022-10-25

申请号：US17022906

申请日：2020-09-16

申请人： Valo Health, Inc.

发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng

IPC分类号： C07D519/00 , C07D215/48 , C07D471/04 , C07D513/04 , A61K31/4545 , A61K31/5377 , A61K45/06 , A61K31/437 , A61K31/4709 , A61K31/497 , C07D495/04

摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

10.

发明授权
Alpha-cinnamide compounds and compositions as HDAC8 inhibitors 有权

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

申请人： Valo Health, Inc.

发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng

IPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10

CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/30

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.