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公开(公告)号：US11547701B2
公开(公告)日：2023-01-10
申请号：US17018196
申请日：2020-09-11
申请人： Valo Health, Inc. , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20230346753A1
公开(公告)日：2023-11-02
申请号：US18073768
申请日：2022-12-02
申请人： Valo Health, Inc. , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10772874B2
公开(公告)日：2020-09-15
申请号：US16538208
申请日：2019-08-12
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D491/048 , C07D487/04 , A61K31/4355 , A61K31/4365 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20190105307A1
公开(公告)日：2019-04-11
申请号：US16212360
申请日：2018-12-06
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , A61K31/496 , A61K31/4365 , A61K31/437 , A61K31/497 , A61K31/519 , C07D471/04 , A61K31/55 , C07D487/04 , C07D491/048 , A61K45/06 , C07D495/04 , C07D491/04 , A61K31/5377
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10456382B2
公开(公告)日：2019-10-29
申请号：US16212360
申请日：2018-12-06
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , A61K31/4355 , A61K31/496 , A61K31/437 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20190388405A1
公开(公告)日：2019-12-26
申请号：US16538208
申请日：2019-08-12
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D491/048 , C07D487/04 , A61K45/06 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/437 , A61K31/4365 , C07D495/04 , C07D491/04 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10272072B2
公开(公告)日：2019-04-30
申请号：US15352184
申请日：2016-11-15
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre Joseph Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4353 , A61K31/497 , A61K31/5377 , A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20210244717A1
公开(公告)日：2021-08-12
申请号：US17018196
申请日：2020-09-11
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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