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公开(公告)号：US20180064849A1
公开(公告)日：2018-03-08
申请号：US15705826
申请日：2017-09-15
CPC分类号： A61L27/3654 , A61F2002/30766 , A61K35/28 , A61K35/32 , A61K38/17 , A61K38/39 , A61L27/222 , A61L27/3834 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06
摘要： An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.
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公开(公告)号：US20200069841A1
公开(公告)日：2020-03-05
申请号：US16660003
申请日：2019-10-22
IPC分类号： A61L27/36 , A61K35/32 , A61L27/38 , A61L27/54 , A61L27/56 , A61K38/39 , A61K35/28 , A61K38/17 , A61L27/22
摘要： An object of the invention is to provide a cartilage regenerative material that is capable of regenerating bone and cartilage using cells. Provided is a cartilage regenerative material including a cell construct, which includes biocompatible polymer blocks and stem cells, in which a plurality of the biocompatible polymer blocks are disposed in gaps between a plurality of the stem cells.
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公开(公告)号：US20190216976A1
公开(公告)日：2019-07-18
申请号：US15705669
申请日：2017-09-15
CPC分类号： A61L27/222 , A61L27/00 , A61L27/225 , A61L27/227 , A61L27/24 , A61L27/3612 , A61L27/3633 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/06 , A61L2430/24
摘要： An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 μm along the thickness.
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公开(公告)号：US20230132346A1
公开(公告)日：2023-04-27
申请号：US18146109
申请日：2022-12-23
发明人： Ichiro SEKIYA , Mitsuru MIZUNO , Hisako KATANO , Nobutake OZEKI , Kentaro NAKAMURA , Tomomi YOSHIDA
IPC分类号： C12N5/0775 , C12N9/64 , A61P19/00
摘要： An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, which makes it possible to obtain a sufficient amount of synovium-derived mesenchymal stem cells from the synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which includes treating a synovial tissue with an enzyme for 2 hours or more; and washing a mixture after the enzyme treatment until a residual enzyme concentration in a supernatant is 0.5 ng/mL or less, to obtain a synovium-derived mesenchymal stem cell.
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公开(公告)号：US20230130549A1
公开(公告)日：2023-04-27
申请号：US18145922
申请日：2022-12-23
发明人： Ichiro SEKIYA , Mitsuru MIZUNO , Hisako KATANO , Nobutake OZEKI , Kentaro NAKAMURA , Tomomi YOSHIDA
IPC分类号： C12N5/0775
摘要： An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, by which proliferation efficiency is improved so that a sufficient amount of synovium-derived mesenchymal stem cells can be obtained from a synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which is a method of producing a synovium-derived mesenchymal stem cell from a synovial tissue, where the production method includes treating the synovial tissue with a mixed enzyme including one or more kinds of collagenases and one or more kinds of neutral proteases for 2 hours or more without causing the synovial tissue to undergo a disinfection step.
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公开(公告)号：US20220241211A1
公开(公告)日：2022-08-04
申请号：US17677045
申请日：2022-02-22
申请人： FUJIFILM Corporation
发明人： Kentaro NAKAMURA , Ryo KOGAWA , Ryuta TAKEGAMI , Yusuke MOCHIZUKI
摘要： An object of the present invention is to provide a composition containing at least microcapsules and cell structures, where the composition can exhibit a high treatment effect in a case of being transplanted into a living body. There is provided a composition including at least (a) a microcapsule containing a polymer hydrogel; and (b) a cell structure containing a biocompatible polymer block and a cell, in which a plurality of biocompatible polymer blocks are arranged in gaps between a plurality of cells, where at least a part of the cell structures are encapsulated in the microcapsules.
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7.发明申请公开(公告)号：US20190262509A1
公开(公告)日：2019-08-29
申请号：US16408894
申请日：2019-05-10
申请人： FUJIFILM Corporation
IPC分类号： A61L31/14 , A61L27/16 , A61F2/02 , A61L27/18 , A61L27/38 , A61L31/16 , A61L31/04 , A61K9/00 , A61K38/28
摘要： According to the present invention, there is provided a membrane for immunoisolation, including a porous membrane that contains a polymer, in which Formulas (I) and (II) are satisfied for at least one surface of the porous membrane, B/A≤0.7 (I) and A≥0.015 (II) (in the formula, A represents a ratio of an N element to a C element on a surface of the membrane, and B represents a ratio of the N element to the C element at a depth of 30 nm from the surface of the membrane); a chamber for transplantation for enclosing a biological constituent therein, including the above-described membrane for immunoisolation on at least a part of a surface forming an inside and an outside of the chamber for transplantation; and a device for transplantation includes the above-described chamber for transplantation enclosing the above-described biological constituent therein. The membrane for immunoisolation of the present invention has a high bioaffinity.
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公开(公告)号：US20180280576A1
公开(公告)日：2018-10-04
申请号：US15941187
申请日：2018-03-30
申请人： FUJIFILM Corporation
发明人： Kentaro NAKAMURA
摘要： An object of the present invention is to provide a method for producing a sheet-like cell structure having excellent strength and shape-maintaining performance, and a sheet-like cell structure having excellent strength and shape-maintaining performance. According to the present invention, there is provided a method for producing a sheet-like cell structure, including: a step of adding a biocompatible macromolecular block, a cell, and a liquid medium onto a culture support body having a plurality of recessed portions on a culture surface, and immersing the biocompatible macromolecular block and the cell in uppermost portions of the recessed portions; and a step of culturing the cell to obtain a sheet-like cell structure.
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9.发明申请公开(公告)号：US20170304503A1
公开(公告)日：2017-10-26
申请号：US15499977
申请日：2017-04-28
申请人： FUJIFILM Corporation
发明人： Kentaro NAKAMURA
CPC分类号： A61L27/507 , A61F2/06 , A61L27/22 , A61L27/222 , A61L27/225 , A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/3804 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/80 , C12M3/00 , C12N5/0068
摘要： An object of the present invention is to provide a cell-containing bioabsorbable tubular structure having molecular permeability, a device for manufacturing the tubular structure, and a method for manufacturing the tubular structure. According to the present invention, there is provided a tubular structure constituted with a cell structure which contains biocompatible polymer blocks and cells, in which the plurality of polymer blocks is disposed in voids between the plurality of cells.
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10.发明申请METHOD FOR PRODUCING BIOCOMPATIBLE MACROMOLECULAR POROUS BODY, BIOCOMPATIBLE MACROMOLECULAR POROUS BODY, BIOCOMPATIBLE MACROMOLECULAR BLOCK AND CELL STRUCTURE 审中-公开生物活性大分子多孔体，生物成分大分子多孔体，生物分子大分子块和细胞结构的生产方法公开(公告)号：US20160303282A1
公开(公告)日：2016-10-20
申请号：US15080827
申请日：2016-03-25
申请人： FUJIFILM Corporation
CPC分类号： A61L27/222 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2300/64 , C07K14/78 , F26B5/06
摘要： An object of the present invention is to provide a biocompatible macromolecular porous body, which enables provision of a cell structure showing a high number of cells and a high number of blood vessels; a method for producing the same; and a biocompatible macromolecular block and a cell structure. According to the present invention, there is provided: a method for producing a biocompatible macromolecular porous body which includes a step (a) of cooling a solution of biocompatible macromolecules to be in an unfrozen state, the difference between a temperature of a portion at the highest liquid temperature within the solution and a temperature of a portion at the lowest liquid temperature within the solution being lower than or equal to 2.5° C. and the temperature of the portion at the highest liquid temperature within the solution being lower than or equal to a melting point of a solvent, a step (b) of freezing the solution of biocompatible macromolecules obtained in the step (a), and a step (c) of freeze-drying the frozen biocompatible macromolecules obtained in the step (b); the biocompatible macromolecular porous body; a biocompatible macromolecular block; and a cell structure.
摘要翻译： 本发明的目的是提供一种生物相容性大分子多孔体，其能够提供显示大量细胞和大量血管的细胞结构; 其制造方法; 和生物相容性大分子嵌段和细胞结构。 根据本发明，提供了一种生物相容性高分子多孔体的制造方法，其特征在于，包括将生物体相容性大分子的溶液冷却至未冷冻状态的工序（a） 溶液中最高的液体温度，溶液中最低液温下的一部分的温度低于或等于2.5℃，溶液中最高液体温度下的部分的温度低于或等于 溶剂的熔点，步骤（b），使步骤（a）中获得的生物相容性大分子的溶液冷冻;以及步骤（c），冷冻干燥步骤（b）中得到的冷冻生物相容性大分子; 生物相容性大分子多孔体; 生物相容性大分子嵌段; 和细胞结构。
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