公开(公告)号：US08892214B2

公开(公告)日：2014-11-18

申请号：US11413432

申请日：2006-04-28

申请人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes ,  James T. Henry

发明人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes ,  James T. Henry

IPC分类号： A61N1/06 ,  A61N1/05

CPC分类号： A61B5/04001 ,  A61B5/6848 ,  A61N1/0551 ,  A61N1/0558

摘要： An implantable electrical lead for applying stimulation energy to bodily tissue, such as a patient's nervous system, from an external power source. The lead is defined by a distal section, an intermediate section and a proximal section, and includes a lead body, a plurality of insulated wires, and a plurality of connector elements. The lead body includes a plurality of electrodes and an anchoring device. The insulated wires are electrically coupled to the electrodes, respectively. A wire intermediate segment extends proximal the lead body and is characterized as having a non-coiled configuration, terminating at a respective connector element for coupling to an external power source. The wire intermediate segments are extendible through a patient's skin and are sealable relative to the skin. The lead is adapted for providing temporary electrical stimulation to a sacral nerve in a bipolar mode, with the anchoring device inhibiting electrode migration.

摘要翻译： 用于从外部电源向身体组织（例如患者神经系统）施加刺激能量的可植入电线。 引线由远端部分，中间部分和近端部分限定，并且包括引线主体，多个绝缘电线和多个连接器元件。 引线体包括多个电极和锚定装置。 绝缘电线分别电耦合到电极。 导线中间段在引线体的近侧延伸，并且其特征在于具有非卷绕构型，终止于相应的连接器元件，用于耦合到外部电源。 线中间段可通过患者的皮肤延伸并且相对于皮肤可密封。 引线适于在双极模式下向骶神经提供临时电刺激，锚定装置抑制电极迁移。

公开(公告)号：US20100268310A1

公开(公告)日：2010-10-21

申请号：US12827435

申请日：2010-06-30

申请人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

发明人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

IPC分类号： A61N1/05

CPC分类号： A61N1/0558

摘要： An implantable medical electrode lead for stimulation of bodily tissue. The lead is adapted for use with a needle lumen diameter of not greater than 0.05 inch, and includes a lead body and a tine assembly. The lead body has a distal section forming at least one exposed electrode surface. The tine assembly includes a plurality of tines each having a base end coupled to an exterior of the lead body immediately adjacent the exposed electrode surface and a free end that is movable relative to the lead body to inhibit axial migration of the lead body upon implantation into a patient. In one embodiment, the lead body is a PNE lead and provides two electrode surfaces for bipolar operation.

摘要翻译： 用于刺激身体组织的可植入医用电极引线。 引线适用于针腔直径不大于0.05英寸，并且包括引线体和齿组件。 引线体具有形成至少一个暴露的电极表面的远端部分。 齿组件包括多个尖齿，每个尖头具有紧邻暴露的电极表面的引线体的外部的基端，以及相对于引线本体可移动的自由端，以阻止引线体在植入时的轴向迁移 病人。 在一个实施例中，引线体是PNE引线，并提供用于双极性操作的两个电极表面。

公开(公告)号：US07949408B2

公开(公告)日：2011-05-24

申请号：US11413310

申请日：2006-04-28

申请人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

发明人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

IPC分类号： A61N1/05

CPC分类号： A61N1/0551

摘要： A system for providing medical electrical stimulation including a lead assembly and a cannula. The lead assembly includes a lead body and a needle tip. The lead body has a distal section and a proximal section. The needle tip is formed of an electrically conductive material and is connected to the distal section of the lead body. The lead body is slidably disposed within a cannula lumen, with a distal end of the cannula being selectively connected to an abutment surface of the needle tip such that the needle tip extends distal the cannula to define a needle probe. With this construction, the lead assembly can be delivered to a desired implantation site via manipulation of the cannula and/or energization of the needle tip, and the cannula can be removed from the lead body without requiring movement of the needle tip.

摘要翻译： 一种用于提供医疗电刺激的系统，包括引线组件和套管。 引线组件包括引线体和针尖。 引线体具有远侧部分和近端部分。 针尖由导电材料形成并且连接到引线主体的远端部分。 引导体可滑动地设置在套管腔内，套管的远端选择性地连接到针尖的邻接表面，使得针尖延伸到套管的远端以限定针头探针。 利用这种结构，引导组件可以通过插管的操作和/或针尖的通电而被输送到期望的植入位置，并且可以不用移动针尖从导线主体移除套管。

公开(公告)号：US07881783B2

公开(公告)日：2011-02-01

申请号：US11413301

申请日：2006-04-28

申请人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

发明人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

IPC分类号： A61N1/05

CPC分类号： A61N1/0558

摘要： An implantable medical electrode lead for stimulation of bodily tissue. The lead is adapted for use with a needle lumen diameter of not greater than 0.05 inch, and includes a lead body and a tine assembly. The lead body has a distal section forming at least one exposed electrode surface. The tine assembly includes a plurality of tines each having a base end coupled to an exterior of the lead body immediately adjacent the exposed electrode surface and a free end that is movable relative to the lead body to inhibit axial migration of the lead body upon implantation into a patient. In one embodiment, the lead body is a PNE lead and provides two electrode surfaces for bipolar operation.

摘要翻译： 用于刺激身体组织的可植入医用电极引线。 引线适用于针腔直径不大于0.05英寸，并且包括引线体和齿组件。 引线体具有形成至少一个暴露的电极表面的远端部分。 齿组件包括多个尖齿，每个尖头具有紧邻暴露的电极表面的引线体的外部的基端，以及相对于引线本体可移动的自由端，以阻止引线体在植入时的轴向迁移 病人。 在一个实施例中，引线体是PNE引线，并提供用于双极性操作的两个电极表面。

公开(公告)号：US20110202097A1

公开(公告)日：2011-08-18

申请号：US13095488

申请日：2011-04-27

申请人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

发明人： Eric H. Bonde ,  Eric M. Stetz ,  Carole A. Tronnes

IPC分类号： A61N1/36

CPC分类号： A61N1/0551

摘要： A system for providing medical electrical stimulation including a lead assembly and a cannula. The lead assembly includes a lead body and a needle tip. The lead body has a distal section and a proximal section. The needle tip is formed of an electrically conductive material and is connected to the distal section of the lead body. The lead body is slidably disposed within a cannula lumen, with a distal end of the cannula being selectively connected to an abutment surface of the needle tip such that the needle tip extends distal the cannula to define a needle probe. With this construction, the lead assembly can be delivered to a desired implantation site via manipulation of the cannula and/or energization of the needle tip, and the cannula can be removed from the lead body without requiring movement of the needle tip.

摘要翻译： 一种用于提供医疗电刺激的系统，包括引线组件和套管。 引线组件包括引线体和针尖。 引线体具有远侧部分和近端部分。 针尖由导电材料形成并且连接到引线主体的远端部分。 引导体可滑动地设置在套管腔内，套管的远端选择性地连接到针尖的邻接表面，使得针尖延伸到套管的远端以限定针头探针。 利用这种结构，引导组件可以通过插管的操作和/或针尖的通电而被输送到期望的植入位置，并且可以不用移动针尖从导线主体移除套管。

公开(公告)号：US08204575B2

公开(公告)日：2012-06-19

申请号：US11835296

申请日：2007-08-07

申请人： Eric M. Stetz ,  Eric H. Bonde ,  Yelena G. Tropsha ,  Thomas Chun

发明人： Eric M. Stetz ,  Eric H. Bonde ,  Yelena G. Tropsha ,  Thomas Chun

IPC分类号： A61B5/05

CPC分类号： A61B90/39 ,  A61B90/11 ,  A61B2090/376 ,  A61B2090/3916 ,  A61B2090/3983 ,  A61N1/0551 ,  A61N1/08

摘要： A locating guide for locating a target tissue site within a patient includes a body, a first substantially radiopaque reference marker on the body, and a second substantially radiopaque reference marker extending from a major surface of the body. The reference markers provide reference points that extend in at least two dimensions, and may be useful for registering a medical image of tissue with an actual location on or within the patient in order to more accurately and precisely locate a target tissue site within the patient. In some embodiments, the second reference marker is oriented at a predetermined angle relative to the major surface of the body, and provides a guide that a clinician may reference in order to orient a medical element introducer when introducing the introducer into the patient to access a particular target tissue site.

摘要翻译： 用于定位患者内的目标组织部位的定位引导件包括主体，身体上的第一基本上不透射线的参考标记以及从主体的主表面延伸的第二基本不透射线的参考标记。 参考标记提供在至少两个维度上延伸的参考点，并且可用于将具有实际位置的组织的医学图像登记在患者身上或内部，以便更精确地和精确地定位患者内的目标组织部位。 在一些实施例中，第二参考标记物相对于主体的主表面以预定角度定向，并且提供临床医生可引用的引导件，以便在将导引器引入患者时进行定位以导向医疗元件导入器 特定目标组织部位。

公开(公告)号：US08954162B2

公开(公告)日：2015-02-10

申请号：US11739982

申请日：2007-04-25

申请人： Eric H. Bonde ,  Martin T. Gerber

发明人： Eric H. Bonde ,  Martin T. Gerber

IPC分类号： A61M31/00 ,  A61B17/34 ,  A61N1/05 ,  A61N1/36 ,  A61B17/06 ,  A61B17/00

CPC分类号： A61N1/0526 ,  A61B17/06109 ,  A61B17/3468 ,  A61B2017/00946 ,  A61B2017/06052 ,  A61N1/0551 ,  A61N1/36071

摘要： The disclosure is directed to a method for implanting a medical device proximate to a target tissue site within an occipital region of a patient, such as proximate to an occipital nerve or a trigeminal nerve. The method comprises introducing an implant tool into a patient to define an insertion path to the target tissue site. The implant tool includes a shape memory cannula and a malleable needle at least partially disposed within an inner lumen of the cannula. The shape of the needle may be changed to accommodate different anatomical structures/features of the patient. Upon withdrawal of the needle from the cannula, the cannula may change shape, thereby changing the shape of the insertion path.

摘要翻译： 本公开涉及一种用于将医疗设备植入接近患者枕骨区域内的目标组织部位（例如靠近枕骨神经或三叉神经）的方法。 该方法包括将植入物工具引入患者以限定到目标组织部位的插入路径。 植入物工具包括形状记忆套管和至少部分地设置在套管的内腔内的有韧性的针。 可以改变针的形状以适应患者的不同解剖结构/特征。 当针从套管中取出时，套管可以改变形状，从而改变插入路径的形状。

公开(公告)号：US08486089B2

公开(公告)日：2013-07-16

申请号：US12706225

申请日：2010-02-16

申请人： Phillip C. Falkner ,  Eric H. Bonde ,  Dale F. Seeley ,  Patrick P. Senarith ,  Steven L. Waldhauser ,  Kendra Yasger

发明人： Phillip C. Falkner ,  Eric H. Bonde ,  Dale F. Seeley ,  Patrick P. Senarith ,  Steven L. Waldhauser ,  Kendra Yasger

IPC分类号： A61B19/00

CPC分类号： A61B17/3431 ,  A61B17/3401 ,  A61B17/3468 ,  A61B2017/3447 ,  A61M25/0026 ,  A61M25/0662 ,  A61M2025/0024 ,  A61M2025/0037 ,  A61N1/0551

摘要： Devices and methods for implanting leads along a spinal cord include an introducer having a main body defining a lumen and one or more collapsible and expandable side sheaths attached to the main body. The side sheaths may be collapsed as the introducer is positioned in a desired location of a patient to maintain a low profile. Once the introducer is placed, the side sheaths may be expanded to receive a lead. A lead may also be inserted through a lumen of the main body. Once the leads are inserted, the introducer may be withdrawn over the leads, leaving the leads implanted in the desired region in a desired orientation.

摘要翻译： 用于沿脊髓植入引线的装置和方法包括导引器，其具有限定内腔的主体和附接到主体的一个或多个可折叠和可扩张的侧护套。 当导引器位于患者的期望位置以保持低轮廓时，侧鞘可能会折叠。 一旦放置引导器，侧护套可以被扩张以接收引线。 引线也可以插入通过主体的内腔。 一旦导线被插入，导引器可以被引出在引线上，留下导线以期望的方向注入所需区域。

公开(公告)号：US20120323254A1

公开(公告)日：2012-12-20

申请号：US13525560

申请日：2012-06-18

申请人： Eric H. Bonde ,  Phillip C. Falkner ,  John B. Horrigan ,  Stuart R. MacDonald ,  Madeline A. Mannion

发明人： Eric H. Bonde ,  Phillip C. Falkner ,  John B. Horrigan ,  Stuart R. MacDonald ,  Madeline A. Mannion

IPC分类号： A61N1/05 ,  A61M25/09 ,  A61B17/34

摘要： Assemblies and methods provide for implantation of multiple medical leads to a defined space within the body, such as the epidural space, through a single entry. A catheter having multiple lumens or alternatively a single oblong lumen may be used. A distal end of the catheter enters the defined space through the single entry such that the distal ends of the multiple lumens or the oblong lumen are present in the defined space. Medical leads are introduced through the multiple lumens or the oblong lumen into the defined space. In some cases, the distal end of the catheter may be deflectable to direct the medical leads within the defined space. In other cases, sheaths may be present within each lumen of the catheter where the sheaths may be extended into the defined space and deflect to direct the medical leads that are being passed through a lumen of the sheaths.

摘要翻译： 组件和方法提供通过单个入口将多个医疗引线植入身体内的限定空间，例如硬膜外腔。 可以使用具有多个腔或可选地单个长圆形管腔的导管。 导管的远端通过单个入口进入限定的空间，使得多个管腔或长圆形管腔的远端存在于限定的空间中。 医疗引线通过多个管腔或长圆形腔引入定义的空间。 在一些情况下，导管的远端可以是可偏转的，以将医疗引线引导到限定的空间内。 在其他情况下，护套可以存在于导管的每个内腔中，其中护套可以延伸到限定的空间中并且偏转以引导通过护套的内腔的医疗引线。

公开(公告)号：US20110118805A1

公开(公告)日：2011-05-19

申请号：US12909625

申请日：2010-10-21

申请人： Xuan Wei ,  Eric H. Bonde

发明人： Xuan Wei ,  Eric H. Bonde

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/36128 ,  A61N1/36135 ,  A61N1/37235 ,  A61N1/37252

摘要： Techniques for managing urinary or fecal incontinence include delivering a first type of therapy to generate a first physiological response and, upon detecting a trigger event, delivering a second type of therapy to generate a second physiological response. The first type of therapy can be delivered on a substantially regular basis, while the second type of therapy is delivered as needed to provide an additional boost of therapy. The trigger event for activating the delivery of the second type of therapy may include input from a sensor that indicates a bladder condition, patient activity level or patient posture, or patient input. In some examples, the therapy is stimulation therapy. In some examples, objective incontinence information is generated based upon the trigger events. The system and/or user may then use this objective incontinence information to adjust therapy or select new therapy programs for improved efficacy.

摘要翻译： 用于管理尿失禁或大便失禁的技术包括递送第一类型的治疗以产生第一生理反应，并且在检测到触发事件时，递送第二类型的治疗以产生第二生理反应。 第一种类型的治疗可以基本上定期地递送，而第二种类型的治疗根据需要被递送以提供额外的治疗效果。 用于激活第二类治疗的递送的触发事件可以包括来自传感器的输入，其指示膀胱状况，患者活动水平或患者姿势或患者输入。 在一些例子中，治疗是刺激疗法。 在一些示例中，基于触发事件来生成客观失禁信息。 然后，系统和/或用户可以使用该目的性尿失禁信息来调整治疗或选择新的治疗程序以提高功效。