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公开(公告)号：US20230158486A1
公开(公告)日：2023-05-25
申请号：US17959346
申请日：2022-10-04
Applicant: Enplas Corporation
Inventor： Yasuhiro WATANABE , Nobuya SUNAGA , Koichi ONO
CPC classification number: B01L3/502 , F16K99/0015 , F16K99/0034 , F16K2099/0084 , B01L2200/027 , B01L2400/0622 , B01L2400/0638 , B01L2400/0481
Abstract: A fluid handling device includes: a channel chip including a well for containing a fluid, a channel connected to the well, a valve disposed on the channel, and a through hole; and a pressing member including a first protrusion and a second protrusion, the first protrusion being for pressing the valve to close the valve, the second protrusion being inserted into the through hole and being for positioning the first protrusion with respect to the valve, the pressing member being rotatable about a rotational axis extending through the second protrusion.
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公开(公告)号：US20190170645A1
公开(公告)日：2019-06-06
申请号：US16268663
申请日：2019-02-06
Applicant: Enplas Corporation
Inventor： Ken KITAMOTO , Koichi ONO
CPC classification number: G01N21/645 , G01N21/05 , G01N21/6428 , G01N33/02 , G01N2021/6439 , G01N2021/6482 , G01N2021/6484
Abstract: This detection device is provided with: a chip including a detection region for detecting a substance to be detected; a light source which emits excitation light; a detector for detecting the fluorescence emitted from a fluorescent substance which labels the substance to be detected, and which is excited by the excitation light; and an optical fiber which includes a core, and a cladding covering the outer peripheral surface of the core, guides, to the detection region, the excitation light emitted from the light source, and guides, to the detector, the fluorescence emitted from the fluorescent substance. The optical fiber is fixed to the chip directly or via a connector. The excitation light emitted from the light source is guided within the core, and reaches the detection region of the chip. The fluorescence emitted from the fluorescent substance is guided within the core and the cladding, and reaches the detector.
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公开(公告)号：US20170314704A1
公开(公告)日：2017-11-02
申请号：US15526498
申请日：2015-10-29
Applicant: Enplas Corporation
Inventor： Ken KITAMOTO , Koichi ONO
Abstract: A liquid handling device has an accommodation part for accommodating a liquid, two or more flow paths each opening to a lower part of a side wall surface of the accommodation part, and a liquid movement suppression part that is disposed in the lower part of the side wall between the openings of two of the flow paths that are adjacent to each other and slows or stops the movement of the liquid along the corner formed by the lower surface of the accommodation part and the side wall surface.
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公开(公告)号：US20170282183A1
公开(公告)日：2017-10-05
申请号：US15474572
申请日：2017-03-30
Applicant: Enplas Corporation
Inventor： Koichi ONO
CPC classification number: B01L3/502784 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , F16K99/0015 , F16K99/0028 , F16K99/0042 , F16K2099/008 , F16K2099/0084
Abstract: A fluid handling device includes: a substrate including a first surface and a second surface which are opposite to each other, wherein a first recess which allows fluid to flow therethrough is formed on the first surface; a film including a third surface and a fourth surface which are opposite to each other, wherein at least a pair of second recesses is formed on the third surface; and at least a pair of electrodes whose shape is defined by the second recesses, the electrodes being disposed in the second recesses and configured to apply an electric field to an inside of the first recess, the film being joined to the substrate such that the first surface and the fourth surface face each other.
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公开(公告)号：US20150021501A1
公开(公告)日：2015-01-22
申请号：US14331249
申请日：2014-07-15
Applicant: Enplas Corporation
Inventor： Koichi ONO , Ken KITAMOTO
IPC: F16K99/00 , F16K31/126
CPC classification number: F16K99/0059 , B01L3/502738 , B01L2300/0864 , B01L2300/0887 , B01L2400/049 , B01L2400/0655 , F16K99/0015 , F16K2099/008 , F16K2099/0084
Abstract: A micro fluid chip includes a first chip and a second chip. The first chip includes a first substrate having a fluid channel and a partition wall, and a first film made of resin. The second chip includes a second substrate having a recess, and a second film made of elastomer. The second film has an elastic modulus higher than that of the first film. The first chip and the second chip are stacked in such a manner that the partition wall and the recess face each other with the first film and the second film therebetween. By setting the inner side of the recess to a negative pressure, a gap is formed between the first film and the partition wall, and thus a fluid channel is opened.
Abstract translation: 微流体芯片包括第一芯片和第二芯片。 第一芯片包括具有流体通道和分隔壁的第一基板和由树脂制成的第一薄膜。 第二芯片包括具有凹部的第二基板和由弹性体制成的第二薄膜。 第二膜具有比第一膜高的弹性模量。 第一芯片和第二芯片以这样的方式堆叠，使得分隔壁和凹部彼此面对，其中第一膜和第二膜彼此面对。 通过将凹部的内侧设定为负压，在第一膜和分隔壁之间形成间隙，从而打开流体流路。
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Patent Agency Ranking
公开(公告)号：US20240110136A1
公开(公告)日：2024-04-04
申请号：US18264691
申请日：2021-02-12
Applicant: ENPLAS CORPORATION
Inventor： Koichi ONO , Yasuhiro WATANABE
CPC classification number: C12M21/08 , C12M23/16 , C12M25/04 , C12M29/10 , C12N5/0691 , C12N5/0697
Abstract: An object is to provide a novel organ-on-a-chip for forming a blood vessel model. An organ-on-a-chip 100 of the present invention is a chip for reproducing a biological process between a cell mass and a blood vessel. The organ-on-a-chip 100 includes a first channel 10, a second channel 20, and a third channel group. The first channel 10 is an introduction channel for introducing vascular endothelial cells for forming a blood vessel model on the inner wall of the first channel 10 through cell culture. The second channel 20 is an introduction channel for introducing a sample containing a cell mass from an upstream side toward a downstream side, and includes a trap portion 22 for trapping the cell mass and located between the upstream side and the downstream side inside the second channel 20. The third channel group includes a plurality of third channels 30, and the third channels 30 are channels that communicate between the first channel 10 and the second channel 20.
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公开(公告)号：US20240091763A1
公开(公告)日：2024-03-21
申请号：US18283183
申请日：2021-03-25
Applicant: Enplas Corporation
Inventor： Koichi ONO , Yasuhiro WATANABE
IPC: B01L3/00
CPC classification number: B01L3/5027 , B01L2200/027
Abstract: The present invention pertains to a liquid handling device that comprises a laminate of a first member and a second member. This liquid handling device is provided with a reservoir that is a space for pooling a liquid and disposed between the first and second members, and a plurality of wells that are plurality of first recesses disposed on the surface of the first member facing the second member. The first and/or second members have flexibility. The first and second members are not bonded between the reservoir and the plurality of wells. When a part of the first or second member, said part corresponding to the reservoir, is pressed in the state where a liquid is pooled in the reservoir, the liquid in the reservoir moves between the first and second members toward the plurality of wells.
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公开(公告)号：US20220241770A1
公开(公告)日：2022-08-04
申请号：US17588386
申请日：2022-01-31
Applicant: Enplas Corporation
Inventor： Hayato INOUE , Koichi ONO , Tomoki NAKAO , Shota TAKAMATSU , Yasuhiro WATANABE
Abstract: A fluid handling device includes a board that includes a board body, and a lid that faces the first surface of the board and is disposed so as to form a space between the board and the lid. The lid includes a lid body including a second surface, and a first through hole which allows for injection of a fluid into the space and includes a first opening that opens onto the second surface and a second opening that opens onto a surface other than the second surface. The lid further includes a spacer which is integrally molded with the lid body; alternatively, the board includes a spacer which is integrally molded with the board body.
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公开(公告)号：US20190178396A1
公开(公告)日：2019-06-13
申请号：US16324179
申请日：2017-08-03
Applicant: Enplas Corporation
Inventor： Koichi ONO , Nobuya SUNAGA
Abstract: This fluid handling device has a substrate, a film, and a sliding member. The substrate has first flow paths, second flow paths, and partition walls formed between one end of the first flow paths and one end of the second flow paths. The film includes a diaphragm, and is arranged above the substrate such that the diaphragm and the partition walls oppose one another. The sliding member has protrusions formed on the back surface thereof, and is arranged above the film with the back surface facing the film. By sliding on the film the sliding member is able switch alternately between a first state in which the protrusions are arranged so as not to oppose the partition walls, and the diaphragm is sandwiched therebetween, and a second state in which the protrusions are arranged opposing the partition walls, and the diaphragm is sandwiched therebetween.
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公开(公告)号：US20230256434A1
公开(公告)日：2023-08-17
申请号：US18107550
申请日：2023-02-09
Applicant: Enplas Corporation
Inventor： Koichi ONO
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2400/0655
Abstract: A cartridge includes a main body, a reservoir disposed inside the main body and configured to store a liquid, and a tube configured such that the liquid taken in from one end of the tube communicating with the reservoir flows out from another end of the tube, in which the tube includes a pressed portion that controls a flow of the liquid by causing the tube to be deformed when the tube is pressed or released from being pressed, and the pressed portion is located outside the main body.
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