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    Polyiodinated aroyloxy esters
    1.
    发明授权
    Polyiodinated aroyloxy esters 失效
    多碘化芳酰基酯

    公开(公告)号：US5466433A

    公开(公告)日：1995-11-14

    申请号：US261794

    申请日：1994-06-20

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    IPC分类号： C07C69/76 ,  A61K49/04 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    摘要： Compounds having the structure ##STR1## wherein Z--COO).sub.m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4;n is an integer from 1 to 20;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有结构的化合物，其中Z-COO）m是多元芳族酸的残基; m为1,2,3或4; n为1〜20的整数， R 1和R 2独立地为H，烷基，氟烷基，环烷基，芳基，芳烷基，烷氧基或芳氧基; R 3和R 4独立地为H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基或酰基氨基; R5是H，烷基，环烷基，芳基，芳烷基，烷氧基烷基或乙酰氨基烷基; 作为x射线成像组合物和方法中的造影剂是有用的。

    Iodinated aroyloxy esters
    2.
    发明授权
    Iodinated aroyloxy esters 失效
    碘化芳酰基酯

    公开(公告)号：US5322679A

    公开(公告)日：1994-06-21

    申请号：US990987

    申请日：1992-12-16

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Paul P. Spara

    IPC分类号： C07C69/76 ,  A61K49/04 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    CPC分类号： A61K49/0433 ,  C07C233/54 ,  C07C233/88 ,  C07C233/91

    摘要： Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid;n is an integer from 1 to 20;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; andR.sup.5 is alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;are useful as contrast agents in x-ray imaging compositions and methods.

    摘要翻译： 具有结构的化合物，其中（Z-COO是碘化芳族酸的残基; n是1至20的整数; R 1和R 2独立地是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基或芳氧基 R 3和R 4独立地是H，烷基，氟烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基或酰基氨基; R 5是烷基，环烷基，芳基，芳烷基，烷氧基烷基或乙酰氨基烷基; 射线成像组合物和方法。

    2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging
    6.
    发明授权
    2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging 失效
    2,4,6-三碘-5-取代 - 氨基 - 间苯二甲酸酯，用作医学诊断成像的X射线造影剂

    公开(公告)号：US5670136A

    公开(公告)日：1997-09-23

    申请号：US586363

    申请日：1996-01-16

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep

    IPC分类号： A61K49/04 ,  C07C233/54

    CPC分类号： C07C233/54 ,  A61K49/0433

    摘要： Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R.sup.1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R.sup.6 is alkyl, cycloalkyl, aryl, or aralkyl; and R.sup.7 is H or --COR.sup.6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.

    摘要翻译： 具有以下结构的化合物：其中Q是0至20的整数; R1是H，烷基，氟烷基，环烷基，芳基，芳烷基，烷氧基烷基或乙酰氨基烷基; R 2，R 3，R 4和R 5独立地是H，烷基，氟代烷基，卤素，羟基，酰基氨基，乙酰氨基烷基，氰基，磺酰基，甲酰胺基或亚磺酰氨基; R6是烷基，环烷基，芳基或芳烷基; 并且R7是H或-COR6可用作医学诊断x射线成像组合物和方法中的造影剂。

    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract
    10.
    发明授权
    Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract 失效
    碘苯基酯和碘苯基磺酸盐在成膜材料中用于胃肠道可视化的组合物

    公开(公告)号：US5372800A

    公开(公告)日：1994-12-13

    申请号：US192234

    申请日：1994-02-04

    申请人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    发明人： Edward R. Bacon ,  Sol J. Daum ,  Kimberly G. Estep ,  Kurt A. Josef ,  Brent D. Douty ,  Carl R. Illig

    IPC分类号： A61K9/107 ,  A61K47/02 ,  A61K47/36 ,  A61K47/38 ,  A61K49/04 ,  C07C69/63

    CPC分类号： A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinX= ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中X = Z，H =卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; R = C 1 -C 25烷基，环烷基，芳基或卤代低级烷基，任选被卤素，氟代低级烷基，低级烷氧基，羟基，羧基或低级烷氧基羰基，低级烯基，低级炔基，低级 - 亚烷基或低级 - 烷氧基 - 羰氧基，n为1-5; y为0-4; w为1-4。