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公开(公告)号：US20230184776A1
公开(公告)日：2023-06-15
申请号：US18063678
申请日：2022-12-08
发明人： Galla Chandra Rao , Mark C. Connelly , Mariano A. Garcia-Blanco , Andrew J. Armstrong , Rhonda L. Bitting
IPC分类号： G01N33/574 , G01N33/543 , G01N33/569
CPC分类号： G01N33/57484 , G01N33/54326 , G01N33/56966 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2333/70589 , G01N2333/47 , G01N2333/4703 , G01N2333/4742 , G01N2333/705 , G01N2333/70503 , G01N2333/70596
摘要： Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
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2.发明申请公开(公告)号：US20180231560A1
公开(公告)日：2018-08-16
申请号：US15511229
申请日：2015-09-15
发明人： Galla Chandra Rao , Mark C. Connelly , Rengasamy BOOMINATHAN , Tian Zhang , Mariano A. Garcia-Blanco , Andrew J. Armstrong
IPC分类号： G01N33/574 , C07K16/30 , C07K16/28
CPC分类号： G01N33/57484 , C07K16/18 , C07K16/2863 , C07K16/289 , C07K16/30 , G01N33/57419 , G01N33/57438
摘要： This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.
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公开(公告)号：US11567081B2
公开(公告)日：2023-01-31
申请号：US16206932
申请日：2018-11-30
申请人： Duke University
发明人： Galla Chandra Rao , Mark C. Connelly , Mariano A. Garcia-Blanco , Andrew J. Armstrong , Rhonda L. Bitting
IPC分类号： G01N33/574 , G01N33/543 , G01N33/569
摘要： Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
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公开(公告)号：US10161939B2
公开(公告)日：2018-12-25
申请号：US14765071
申请日：2013-05-31
发明人： Galla Chandra Rao , Mark C. Connelly , Mariano A. Garcia-Blanco , Andrew J. Armstrong , Rhonda L. Bitting
IPC分类号： G01N33/574 , G01N33/543 , G01N33/569
摘要： Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
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公开(公告)号：US20160077097A1
公开(公告)日：2016-03-17
申请号：US14765071
申请日：2013-05-31
申请人： DUKE UNIVERSITY
发明人： Galla Chandra Rao , Mark C. Connelly , Mariano A. Garcia-Blanco , Andrew J. Armstrong , Rhonda L. Bitting
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N33/54326 , G01N33/56966 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2333/47 , G01N2333/4703 , G01N2333/4742 , G01N2333/705 , G01N2333/70503 , G01N2333/70589 , G01N2333/70596
摘要： Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
摘要翻译： 提供了用于检测或分离受试者中的循环肿瘤细胞（CTC）的方法。 所述方法可以包括检测至少一种上皮间质转化（EMT）生物标志物的表达。 还提供了用于检测或隔离四氯化碳的试剂盒。 试剂盒可以包括至少一种EMT生物标志物的抗体。 进一步提供了预测受试者对癌症药物的反应性的方法，靶向受试者中癌症药物递送的方法，对受试者提供癌症预后的方法，以及用于跟踪受试者的癌症进展的方法。
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公开(公告)号：US20190271703A1
公开(公告)日：2019-09-05
申请号：US16345422
申请日：2017-10-26
申请人： DUKE UNIVERSITY
IPC分类号： G01N33/574 , C07K16/28 , A61K45/06 , A61P35/04 , A61K39/395 , A61K47/68
摘要： The current disclosure relates to biomarkers for chemo-residual tumor cells cancer in a subject and methods of treating same.
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公开(公告)号：US20190107542A1
公开(公告)日：2019-04-11
申请号：US16206932
申请日：2018-11-30
申请人： Duke University
发明人： Galla Chandra Rao , Mark C. Connelly , Mariano A. Garcia-Blanco , Andrew J. Armstrong , Rhonda L. Bitting
IPC分类号： G01N33/574 , G01N33/569 , G01N33/543
摘要： Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
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