公开(公告)号：US08865460B2

公开(公告)日：2014-10-21

申请号：US11996610

申请日：2006-08-11

Applicant: David E. Orr ,  Karen J. L. Burg

Inventor： David E. Orr ,  Karen J. L. Burg

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/42 ,  C12M1/12

CPC classification number: C12M25/14 ,  C12M23/34 ,  C12M29/04 ,  C12M35/08

Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.

Abstract translation: 公开了多室细胞共培养系统。 该系统可用于在动态三维体外环境中促进分离细胞的生长和发育。 系统的细胞室（10）可以与包含不同类型的细胞的相邻室进行生物化学连通，但不同的细胞类型彼此保持物理分离。 此外，每个电池室的局部环境可以独立控制。 例如，通过单个电池室的流体流动特性可以被独立地控制并维持在系统的每个分开的室中。

公开(公告)号：USD658306S1

公开(公告)日：2012-04-24

申请号：US29363365

申请日：2010-06-08

Applicant: Matthew R. Gevaert ,  David E. Orr ,  Margaret Rebecca Drumm

Designer： Matthew R. Gevaert ,  David E. Orr ,  Margaret Rebecca Drumm

公开(公告)号：US20080293135A1

公开(公告)日：2008-11-27

申请号：US11996610

申请日：2006-08-11

Applicant: David E. Orr ,  Karen J.L. Burg

Inventor： David E. Orr ,  Karen J.L. Burg

IPC: C12N5/06 ,  C12M1/12

CPC classification number: C12M25/14 ,  C12M23/34 ,  C12M29/04 ,  C12M35/08

Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.

Abstract translation: 公开了多室细胞共培养系统。 该系统可用于在动态三维体外环境中促进分离细胞的生长和发育。 系统的细胞室（10）可以与包含不同类型的细胞的相邻室进行生物化学连通，但不同的细胞类型彼此保持物理分离。 此外，每个电池室的局部环境可以独立控制。 例如，通过单个电池室的流体流动特性可以被独立地控制并维持在系统的每个分开的室中。

公开(公告)号：US09575055B2

公开(公告)日：2017-02-21

申请号：US13379152

申请日：2010-06-18

Applicant: Matthew R. Gevaert ,  David E. Orr

Inventor： Matthew R. Gevaert ,  David E. Orr

IPC: C12M3/00 ,  C12M1/00 ,  G01N33/50 ,  C12M1/42

CPC classification number: G01N33/5029 ,  C12M23/34 ,  C12M23/44 ,  C12M29/04 ,  C12M35/08 ,  C12N5/0693 ,  C12N2500/00 ,  C12N2502/00 ,  C12N2503/00 ,  C12N2503/02 ,  G01N33/5011 ,  G01N33/5091

Abstract: Disclosed herein are bioreactor systems and methods of utilizing said systems.

Abstract translation: 本文公开了生物反应器系统和利用所述系统的方法。

公开(公告)号：US09161850B2

公开(公告)日：2015-10-20

申请号：US13008366

申请日：2011-01-18

Applicant: Erik E. Rasmussen ,  Bent Ohlenschlaeger ,  William K. Dierking ,  Blayne A. Roeder ,  David E. Orr

Inventor： Erik E. Rasmussen ,  Bent Ohlenschlaeger ,  William K. Dierking ,  Blayne A. Roeder ,  David E. Orr

IPC: A61F2/06 ,  A61F2/95 ,  A61M25/00 ,  A61M25/01

CPC classification number: A61F2/95 ,  A61M25/0041 ,  A61M25/0138

Abstract: An introducer assembly for introducing a stent-graft or other device into a vessel of a patient is provided with a dilator tip which is naturally curved, preferably to be substantially a U-shape. The dilator tip is flexible so as to be able to become substantially straight with a guide wire therein and yet to be able to curve back towards its natural curvature during deployment of an implant. The curvature of the dilator tip can ensure that the dilator tip does not cause damage to the vessel wall during deployment of an implant carried thereon, as can occur with straight dilator tips.

Abstract translation: 用于将支架移植物或其他装置引入患者血管的导引器组件设置有自然弯曲的扩张器尖端，优选地基本上为U形。 扩张器尖端是柔性的，以便能够在其中具有导丝线而变得基本上直线，并且在展开植入物期间能够向着其自然曲率向后弯曲。 扩张器尖端的曲率可以确保扩张器尖端在展开承载在其上的植入物时不会对血管壁造成损伤，如同直的扩张器尖端一样。

公开(公告)号：US20120141656A1

公开(公告)日：2012-06-07

申请号：US13356324

申请日：2012-01-23

Applicant: David E. Orr ,  William F. Moore ,  Siddharth Vad

Inventor： David E. Orr ,  William F. Moore ,  Siddharth Vad

IPC: B05D3/14 ,  B05C9/04

CPC classification number: B05B5/08 ,  B05B5/0255 ,  B05B5/087 ,  B05B5/12 ,  B05D1/04 ,  B05D2252/10 ,  B05D2254/02 ,  B05D2254/04 ,  D01D5/0061 ,  D01D5/0084

Abstract: An electrospinning apparatus may include a first spinneret and a second spinneret, each including a reservoir and an orifice. The first and second spinnerets may have first and second electrical charges, respectively. The first spinneret orifice may be located substantially opposite the second spinneret orifice. The first and second spinnerets may be used to prepare a medical device defining a lumen with a proximal end, a distal end, a luminal surface and an abluminal surface. The first spinneret orifice distal end may be configured to be located outside of the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device abluminal surface. The second spinneret orifice distal end may be configured to be located in the medical device lumen and between about 0.1 inches and about 6.0 inches from the medical device luminal surface.

Abstract translation: 电纺丝装置可以包括第一喷丝头和第二喷丝头，每个喷丝头包括储存器和孔口。 第一和第二喷丝头可以分别具有第一和第二电荷。 第一喷丝孔可以与第二喷丝孔大致相对。 第一和第二喷丝头可用于制备限定具有近端，远端，管腔表面和腹腔表面的内腔的医疗装置。 第一喷丝孔的远端可被配置为位于医疗装置内腔的外侧，并且距离医疗装置的外腔表面约0.1英寸至约6.0英寸。 第二喷丝孔口远端可被配置为位于医疗装置内腔中，并且距离医疗装置腔表面约0.1英寸至约6.0英寸。

公开(公告)号：US20120136425A1

公开(公告)日：2012-05-31

申请号：US13379962

申请日：2010-06-29

Applicant: David E. Orr

Inventor： David E. Orr

IPC: A61F2/84

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2250/0018 ,  A61F2250/0029 ,  A61M25/0054

Abstract: A delivery system for an intraluminal medical device comprises an elongate tubular sheath 20 and an elongate tubular pusher 50 slidably disposed within a lumen of the sheath and having a flexible configuration due to circumferentially-extending fins 154 along its exterior surface. The spacing and/or the size of the fins 154 may vary along the pusher 50. Different regions of the pusher 50 may be of materials with different flexibility.

Abstract translation: 用于管腔内医疗装置的递送系统包括细长管状护套20和可滑动地设置在护套的内腔内的细长管状推动器50，并且由于沿着其外表面沿周向延伸的翅片154具有柔性构造。 翅片154的间隔和/或尺寸可以沿着推动器50变化。推动器50的不同区域可以是具有不同柔性的材料。

公开(公告)号：US20110166516A1

公开(公告)日：2011-07-07

申请号：US13059856

申请日：2009-08-24

Applicant: David E. Orr

Inventor： David E. Orr

IPC: A61M29/00

CPC classification number: A61M25/1002 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0093 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2037/003

Abstract: There are disclosed apparatus and methods for treating tissue by delivering at least one therapeutic agent into the tissue. In one embodiment, the apparatus comprises a catheter (30, 40) and a balloon member (150) disposed on a distal region of the catheter. A plurality of pockets (164) are disposed on the balloon member (150), and a plurality of needles (180) are associated with each of the plurality of pockets. The plurality of needles (180) are configured to engage tissue when the balloon (150) is in the inflated state, and further are configured to disperse a therapeutic agent from an associated pocket (164) into the tissue when the balloon (150) is in the inflated state. A first needle (180a) of the plurality of needles may comprise a length that is different than a second needle (180b), permitting the delivery of first and second therapeutic agents to different depths within the tissue.

Abstract translation: 公开了通过将至少一种治疗剂递送到组织中来治疗组织的装置和方法。 在一个实施例中，该装置包括设置在导管的远侧区域上的导管（30,40）和球囊构件（150）。 多个袋（164）设置在球囊构件（150）上，并且多个针（180）与多个凹穴中的每一个相关联。 多个针（180）构造成当球囊（150）处于充气状态时接合组织，并且还被配置成当球囊（150）为（或）球囊）时将治疗剂从相关联的口袋（164）分散到组织中 处于膨胀状态。 多个针的第一针（180a）可以包括与第二针（180b）不同的长度，允许第一和第二治疗剂递送到组织内的不同深度。

公开(公告)号：US07327845B1

公开(公告)日：2008-02-05

申请号：US10717168

申请日：2003-11-18

Applicant: David E. Orr

Inventor： David E. Orr

IPC: H04K1/00

CPC classification number: H04L9/0656 ,  H04L2209/12

Abstract: An apparatus and method is disclosed for establishing a one-time cryptographic pad between a communicating pair, a communicating pair comprising a pair of transmitter-receivers, each of the pair having a plurality of cryptographic devices in common. The communicating pair also store previously exchanged messages and transmissions, a transmission comprising secure data exchanged by the pair that is independent of message content. The first transmitter-receiver randomly selects a cryptographic device and a previous transmission or message that has been sent to the second transmitter-receiver. The first transmitter-receiver also randomly selects a reference to a message or transmission previously sent by the second transmitter-receiver. The first transmitter-receiver encrypts the previously sent transmission or message and the reference to the message or transmission previously sent by the second transmitter-receiver and sends to the second transmitter-receiver. The second transmitter-receiver discovers the encryption device used by the first transmitter-receiver, verifies the message or transmission sent by the first transmitter-receiver, and uses the decrypted reference to access the previously sent transmission or message, then uses the discovered encryption device to encrypt the previously sent transmission or message and sends to the first transmitter-receiver. The first transmitter-receiver decrypts the transmission or message previously sent by the second transmitter-receiver, and authenticates. If authentication is successful, the first transmitter-receiver encrypts using the randomly selected cryptographic device.

Abstract translation: 公开了一种用于在通信对之间建立一次密码板的装置和方法，包括一对发射机 - 接收机的通信对，该对中的每一对具有共同的多个加密装置。 通信对还存储先前交换的消息和传输，包括由该对交换的独立于消息内容的安全数据的传输。 第一发射机 - 接收机随机选择已经发送到第二发射机 - 接收机的加密装置和先前的传输或消息。 第一发射机 - 接收机还随机选择对先前由第二发射机 - 接收机发射的消息或传输的参考。 第一发射机 - 接收机加密先前发送的传输或消息以及先前由第二发射机 - 接收机发送的消息或传输的引用，并发送给第二发射机 - 接收机。 第二发射机 - 接收机发现由第一发射机 - 接收机使用的加密装置，验证由第一发射机 - 接收机发送的消息或传输，并使用解密的参考来访问先前发送的传输或消息，然后使用所发现的加密装置 加密先前发送的传输或消息并发送到第一发射机 - 接收机。 第一发射机 - 接收机解密先前由第二发射机 - 接收机发送的传输或消息，并进行认证。 如果认证成功，则第一发射机 - 接收机使用随机选择的加密设备进行加密。

公开(公告)号：US09173983B2

公开(公告)日：2015-11-03

申请号：US12936490

申请日：2009-04-06

Applicant: Steven J Charlebois ,  William Kurt Dierking ,  David E. Orr

Inventor： Steven J Charlebois ,  William Kurt Dierking ,  David E. Orr

IPC: A61L31/14 ,  A61L31/02 ,  A61L31/08

CPC classification number: A61F2/82 ,  A61F2210/00 ,  A61F2210/0076 ,  A61F2240/00 ,  A61L31/022 ,  A61L31/082 ,  A61L31/088 ,  A61L31/14 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  C22F1/006 ,  C22F1/10 ,  C23C16/56

Abstract: A method of forming a surface structure of a component of a medical devices includes forming a fatigue-resistant portion, which entails forming a first layer comprising a transition metal selected from the group consisting of Ta, Nb, Mo, V, Mn, Fe, Cr, Co, Ni, Cu, and Si on at least a portion of a surface of the component, where the surface comprises a nickel-titanium alloy, and alloying the transition metal of the first layer with the nickel-titanium alloy of the surface. The method further includes forming a rough outer surface of the fatigue-resistant portion where the rough outer surface is adapted for adhesion of a material thereto.

Abstract translation: 形成医疗器械的部件的表面结构的方法包括形成抗疲劳部分，其需要形成包含选自Ta，Nb，Mo，V，Mn，Fe， Cr，Co，Ni，Cu和Si组分的表面的至少一部分，其中表面包括镍 - 钛合金，并且将第一层的过渡金属与表面的镍 - 钛合金合金化 。 该方法还包括形成耐磨部分的粗糙外表面，其中粗外表面适于将材料粘附到其上。