公开(公告)号：US08865460B2

公开(公告)日：2014-10-21

申请号：US11996610

申请日：2006-08-11

Applicant: David E. Orr ,  Karen J. L. Burg

Inventor： David E. Orr ,  Karen J. L. Burg

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/42 ,  C12M1/12

CPC classification number: C12M25/14 ,  C12M23/34 ,  C12M29/04 ,  C12M35/08

Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.

Abstract translation: 公开了多室细胞共培养系统。 该系统可用于在动态三维体外环境中促进分离细胞的生长和发育。 系统的细胞室（10）可以与包含不同类型的细胞的相邻室进行生物化学连通，但不同的细胞类型彼此保持物理分离。 此外，每个电池室的局部环境可以独立控制。 例如，通过单个电池室的流体流动特性可以被独立地控制并维持在系统的每个分开的室中。

公开(公告)号：USD658306S1

公开(公告)日：2012-04-24

申请号：US29363365

申请日：2010-06-08

Applicant: Matthew R. Gevaert ,  David E. Orr ,  Margaret Rebecca Drumm

Designer： Matthew R. Gevaert ,  David E. Orr ,  Margaret Rebecca Drumm

公开(公告)号：US20080293135A1

公开(公告)日：2008-11-27

申请号：US11996610

申请日：2006-08-11

Applicant: David E. Orr ,  Karen J.L. Burg

Inventor： David E. Orr ,  Karen J.L. Burg

IPC: C12N5/06 ,  C12M1/12

CPC classification number: C12M25/14 ,  C12M23/34 ,  C12M29/04 ,  C12M35/08

Abstract: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different cell types are maintained physically separated from one another. In addition, the local environment of each cell chamber can be independently controlled. For example, fluid flow characteristics through a single cell chamber can be independently controlled and maintained for each separate chamber of the system.

Abstract translation: 公开了多室细胞共培养系统。 该系统可用于在动态三维体外环境中促进分离细胞的生长和发育。 系统的细胞室（10）可以与包含不同类型的细胞的相邻室进行生物化学连通，但不同的细胞类型彼此保持物理分离。 此外，每个电池室的局部环境可以独立控制。 例如，通过单个电池室的流体流动特性可以被独立地控制并维持在系统的每个分开的室中。

公开(公告)号：US09173983B2

公开(公告)日：2015-11-03

申请号：US12936490

申请日：2009-04-06

Applicant: Steven J Charlebois ,  William Kurt Dierking ,  David E. Orr

Inventor： Steven J Charlebois ,  William Kurt Dierking ,  David E. Orr

IPC: A61L31/14 ,  A61L31/02 ,  A61L31/08

CPC classification number: A61F2/82 ,  A61F2210/00 ,  A61F2210/0076 ,  A61F2240/00 ,  A61L31/022 ,  A61L31/082 ,  A61L31/088 ,  A61L31/14 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  C22F1/006 ,  C22F1/10 ,  C23C16/56

Abstract: A method of forming a surface structure of a component of a medical devices includes forming a fatigue-resistant portion, which entails forming a first layer comprising a transition metal selected from the group consisting of Ta, Nb, Mo, V, Mn, Fe, Cr, Co, Ni, Cu, and Si on at least a portion of a surface of the component, where the surface comprises a nickel-titanium alloy, and alloying the transition metal of the first layer with the nickel-titanium alloy of the surface. The method further includes forming a rough outer surface of the fatigue-resistant portion where the rough outer surface is adapted for adhesion of a material thereto.

Abstract translation: 形成医疗器械的部件的表面结构的方法包括形成抗疲劳部分，其需要形成包含选自Ta，Nb，Mo，V，Mn，Fe， Cr，Co，Ni，Cu和Si组分的表面的至少一部分，其中表面包括镍 - 钛合金，并且将第一层的过渡金属与表面的镍 - 钛合金合金化 。 该方法还包括形成耐磨部分的粗糙外表面，其中粗外表面适于将材料粘附到其上。

公开(公告)号：US08821563B2

公开(公告)日：2014-09-02

申请号：US13124518

申请日：2009-10-16

Applicant: David E. Orr ,  William Kurt Dierking ,  Jesper S. Petersen

Inventor： David E. Orr ,  William Kurt Dierking ,  Jesper S. Petersen

IPC: A61F2/06 ,  A61F2/966 ,  A61F2/95

CPC classification number: A61F2/95 ,  A61F2/966 ,  A61F2002/9511 ,  A61F2002/9665

Abstract: A dilator tip (100) for deploying and positioning an endovascular device (570) at a treatment site includes an elongate body (105) having at least two substantially longitudinal channels (110) in an outer surface (105s) of the body and at least two deployment struts (115). Each deployment strut (115) has a free end (120) releasably attached to a proximal edge (575) of an endovascular device (570) to be deployed, a constrained end (125) restrained within one of the longitudinal channels (110), and a pivot portion (130) between the free end (120) and the constrained end (125). In an undeployed configuration of the dilator tip (100), the free ends (120) reside within the longitudinal channels (110), and in a deployed configuration of the dilator tip (100), the free ends (120) are pivotally extended away from the longitudinal channels (110) by way of the pivot portions (130).

Abstract translation: 用于在处理部位展开和定位血管内装置（570）的扩张器尖端（100）包括细长主体（105），其在主体的外表面（105s）中具有至少两个基本上纵向的通道（110），并且至少 两个部署支柱（115）。 每个部署支柱（115）具有可释放地附接到待部署的血管内装置（570）的近侧边缘（575）的自由端（120），限制在所述纵向通道（110）之一内的约束端（125） 以及在自由端（120）和约束端（125）之间的枢轴部分（130）。 在扩张器尖端（100）的未部署构造中，自由端（120）位于纵向通道（110）内，并且在扩张器尖端（100）的展开构造中，自由端（120）被枢转地延伸远离 从所述纵向通道（110）通过所述枢转部分（130）。

公开(公告)号：US08357118B2

公开(公告)日：2013-01-22

申请号：US13059856

申请日：2009-08-24

Applicant: David E. Orr

Inventor： David E. Orr

IPC: A61M29/00

CPC classification number: A61M25/1002 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0093 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2037/003

Abstract: There are disclosed apparatus and methods for treating tissue by delivering at least one therapeutic agent into the tissue. In one embodiment, the apparatus comprises a catheter (30, 40) and a balloon member (150) disposed on a distal region of the catheter. A plurality of pockets (164) are disposed on the balloon member (150), and a plurality of needles (180) are associated with each of the plurality of pockets. The plurality of needles (180) are configured to engage tissue when the balloon (150) is in the inflated state, and further are configured to disperse a therapeutic agent from an associated pocket (164) into the tissue when the balloon (150) is in the inflated state. A first needle (180a) of the plurality of needles may comprise a length that is different than a second needle (180b), permitting the delivery of first and second therapeutic agents to different depths within the tissue.

Abstract translation: 公开了通过将至少一种治疗剂递送到组织中来治疗组织的装置和方法。 在一个实施例中，该装置包括设置在导管的远侧区域上的导管（30,40）和球囊构件（150）。 多个袋（164）设置在球囊构件（150）上，并且多个针（180）与多个凹穴中的每一个相关联。 多个针（180）构造成当球囊（150）处于充气状态时接合组织，并且还被配置成当球囊（150）为（或）球囊）时将治疗剂从相关联的口袋（164）分散到组织中 处于膨胀状态。 多个针的第一针（180a）可以包括与第二针（180b）不同的长度，允许第一和第二治疗剂递送到组织内的不同深度。

公开(公告)号：US20120078348A1

公开(公告)日：2012-03-29

申请号：US13322344

申请日：2010-05-27

Applicant: David E. Orr

Inventor： David E. Orr

IPC: A61F2/82

CPC classification number: A61F2/915 ,  A61F2002/072 ,  A61F2230/0054 ,  A61F2250/0068

Abstract: The present invention provides apparatus and methods for treating tissue by delivering at least one therapeutic agent to the tissue. In one embodiment, the apparatus comprises first and second membranes (30,32) in sealing engagement with strut segments (25,26) of at least one stent. A first membrane pocket is disposed between the first and second membranes(30,32), and a first therapeutic agent is disposed within the first membrane pocket. In other embodiments, the first and second membranes (130, 140) may be disposed between first and second spaced apart stents (114, 122), or only a single membrane may be provided. In each instance, the quantity of the therapeutic agent delivered is not limited by the surface area of the stent struts or the lumen diameter of the struts.

Abstract translation: 本发明提供了通过将至少一种治疗剂递送至组织来治疗组织的装置和方法。 在一个实施例中，该装置包括与至少一个支架的支柱段（25,26）密封接合的第一和第二膜（30,32）。 第一膜袋设置在第一和第二膜（30,32）之间，并且第一治疗剂设置在第一膜袋内。 在其他实施例中，第一和第二膜（130,140）可以设置在第一和第二间隔开的支架（114,122）之间，或者可以仅提供单个膜。 在每种情况下，递送的治疗剂的量不受支架支柱的表面积或支柱的管腔直径的限制。

公开(公告)号：US20110137403A1

公开(公告)日：2011-06-09

申请号：US13008366

申请日：2011-01-18

Applicant: Erick E. Rasmussen ,  Bent Ohlenschlaeger ,  William K. Dierking ,  Blayne A. Roeder ,  David E. Orr

Inventor： Erick E. Rasmussen ,  Bent Ohlenschlaeger ,  William K. Dierking ,  Blayne A. Roeder ,  David E. Orr

IPC: A61F2/82

CPC classification number: A61F2/95 ,  A61M25/0041 ,  A61M25/0138

Abstract: An introducer assembly for introducing a stent-graft or other device into a vessel of a patient is provided with a dilator tip which is naturally curved, preferably to be substantially a U-shape. The dilator tip is flexible so as to be able to become substantially straight with a guide wire therein and yet to be able to curve back towards its natural curvature during deployment of an implant. The curvature of the dilator tip can ensure that the dilator tip does not cause damage to the vessel wall during deployment of an implant carried thereon, as can occur with straight dilator tips.

Abstract translation: 用于将支架移植物或其他装置引入患者血管的导引器组件设置有自然弯曲的扩张器尖端，优选地基本上为U形。 扩张器尖端是柔性的，以便能够在其中具有导丝线而变得基本上直线，并且在展开植入物期间能够向着其自然曲率向后弯曲。 扩张器尖端的曲率可以确保扩张器尖端在展开承载在其上的植入物时不会对血管壁造成损伤，如同直的扩张器尖端一样。

公开(公告)号：US07799261B2

公开(公告)日：2010-09-21

申请号：US12274530

申请日：2008-11-20

Applicant: David E. Orr ,  William F. Moore

Inventor： David E. Orr ,  William F. Moore

IPC: B29C67/00

CPC classification number: B05D1/04 ,  B05B5/0255 ,  B05B5/08 ,  B05B5/087 ,  B05B5/12 ,  B05D2252/10 ,  B05D2254/02 ,  B05D2254/04 ,  D01D5/0061 ,  D01D5/0084

Abstract: The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.

Abstract translation: 本公开涉及一种用于涂覆医疗装置的方法和装置。 该方法包括提供静电纺丝装置，同时将至少一种溶液静电纺丝到第一表面和相对的第二表面上。 该装置包括第一喷丝头和第二喷丝头。 能量源电耦合到第一喷丝头和第二喷丝头。 第一喷丝头和第二喷丝头包括流体耦合到储存器的储存器和孔口。 第一喷丝孔与第二喷丝孔大致相对。

公开(公告)号：US20100161027A1

公开(公告)日：2010-06-24

申请号：US12641125

申请日：2009-12-17

Applicant: David E. Orr

Inventor： David E. Orr

IPC: A61F2/06 ,  A61F2/82

CPC classification number: A61F2/91 ,  A61F2/07 ,  A61F2/848 ,  A61F2/89 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2220/0016 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2250/0048

Abstract: A stent includes a main body having proximal and distal ends, and at least one conformance strut coupled to the proximal end of the main body. A portion of the at least one conformance strut extends proximal to a proximal end of a graft material in a compressed delivery configuration, and further is aligned inside the proximal end of the graft material in an expanded deployed configuration. In the deployed configuration, the proximal conformance strut may at least partially encircle the graft material just distal to the proximal end of the graft material, which may reduce the likelihood of infolding at the proximal edge of the graft material and potential endoleaks.

Abstract translation: 支架包括具有近端和远端的主体，以及耦合到主体的近端的至少一个一致支柱。 所述至少一个一致性支柱的一部分以压缩的输送构型延伸到移植物材料的近端附近，并且在扩展的展开构型中进一步在移植材料的近端内对准。 在展开的构造中，近端一致性支柱可以至少部分地围绕移植物材料，其刚好在移植物材料的近端的远侧，这可以减少在移植物材料的近端处引起折叠的可能性和潜在的内漏。