Anthraquinone derivatives and their use as protein absorbents
    2.
    发明授权
    Anthraquinone derivatives and their use as protein absorbents 失效
    蒽醌衍生物及其作为蛋白质吸收剂的用途

    公开(公告)号:US4864018A

    公开(公告)日:1989-09-05

    申请号:US885146

    申请日:1986-07-14

    CPC分类号: C12N9/0006 C09B62/004

    摘要: A compound of the formula: ##STR1## wherein X is a non-chromophoric bridging group which provides at least three single covalent bonds between Ring B and the group R;R is a group containing a reactive halogen atom; andeach A independently is H or an acidic group;provided that the molecule contains sufficient acidic groups to render it water soluble and then when X provides only 3 covalent bonds between Ring B and R, the latter is not a chlorodifuoropyrimidyl group, which is suitable for the preparation of a protein adsorbent or precipitant for use in the separation of mixtures of proteins.

    摘要翻译: 下式的化合物:其中X是在B环和R基团之间提供至少三个单个共价键的非发色桥连基团; R是含有反应性卤素原子的基团; 每个A独立地为H或酸性基团; 条件是分子含有足够的酸性基团以使其具有水溶性,然后当X在环B和R之间仅提供3个共价键时,后者不是氯二氟嘧啶基,其适用于制备蛋白质吸附剂或沉淀剂以供使用 在蛋白质混合物的分离中。

    Prion protein binding materials and methods of use
    4.
    发明授权
    Prion protein binding materials and methods of use 有权
    朊病毒蛋白结合材料及使用方法

    公开(公告)号:US07393658B2

    公开(公告)日:2008-07-01

    申请号:US10817117

    申请日:2004-04-02

    IPC分类号: G01N33/53

    CPC分类号: G01N33/6896

    摘要: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), recombinant prion protein (PrPr), and proteinase resistant prion protein (PrPres). Prions from various species, including humans and hamsters, are bound by the binding materials.

    摘要翻译: 朊病毒蛋白结合材料和使用结合材料从样品如生物流体或环境样品中检测或除去朊病毒蛋白的方法。 结合材料能够结合一种或多种形式的朊病毒蛋白,包括细胞朊蛋白(PrPc),感染性朊病毒蛋白(PrPsc),重组朊蛋白(PrPr)和蛋白酶抗性朊病毒蛋白(PrPres)。 来自各种物种的朊病毒,包括人类和仓鼠,都受到结合物质的束缚。