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公开(公告)号：US20230363672A1
公开(公告)日：2023-11-16
申请号：US18319085
申请日：2023-05-17
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER , Dvin I. ADALIAN , Peter PETILLO , Muhammad Musab JILANI , Xiomara L. MADERO , Deepan KISHORE KUMAR
IPC: A61B5/1486 , C12N11/14 , A61B5/145 , A61B5/1459 , G01N27/327 , C12N9/02 , C12N11/02
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1459 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/03003 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/0301 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/0302 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/0303 , C12Y101/03037 , C12Y101/03038 , C12Y101/0304 , C12Y101/03041
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20190060218A1
公开(公告)日：2019-02-28
申请号：US16044124
申请日：2018-07-24
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER , Richard Daniel SMITH, JR.
Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：US20140026413A1
公开(公告)日：2014-01-30
申请号：US14038702
申请日：2013-09-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
IPC: H05K3/10
CPC classification number: H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
Abstract translation: 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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公开(公告)号：US20210321918A1
公开(公告)日：2021-10-21
申请号：US17314930
申请日：2021-05-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER , Dvin ADALIAN , Peter PETILLO , Muhammad Musab JILANI , Xiomara L. MADERO , Deepan KISHORE KUMAR
IPC: A61B5/1486 , C12N11/02 , C12N9/02 , A61B5/145 , A61B5/1459 , G01N27/327 , C12N11/14
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20170072399A1
公开(公告)日：2017-03-16
申请号：US15360691
申请日：2016-11-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya RAJAGOPAL , Samson CHEN , Axel SCHERER , Christopher I. WALKER
CPC classification number: B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0893 , B01L2300/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , C12Q1/686 , H05K1/0212 , H05K1/0272 , H05K1/028 , H05K3/46 , H05K3/4697 , Y10T29/49124
Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
Abstract translation: 公开了用于进行聚合酶链式反应（PCR）的PC板流体装置。 这些装置包括印刷电路板和PCR室。 PCR室是流体室，位于PC板中，或者位于PC板的一部分。 PC板可以包括带有温度传感器和控制器的线圈跟踪加热元件。
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Patent Agency Ranking
公开(公告)号：US20130183676A1
公开(公告)日：2013-07-18
申请号：US13740112
申请日：2013-01-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/6408
Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.
Abstract translation: 描述了在没有任何滤光器的情况下检测荧光物质或荧光团的寿命的装置和方法。 基于测量的荧光寿命，可以鉴定或测定与荧光团如小有机分子，聚合物，肽，糖和核酸连接的分子或化合物。
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公开(公告)号：US20190090796A1
公开(公告)日：2019-03-28
申请号：US16144079
申请日：2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER
IPC: A61B5/1486 , C12N9/02 , C12N11/02
Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20180338681A1
公开(公告)日：2018-11-29
申请号：US15987843
申请日：2018-05-23
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Axel SCHERER , Peter A. PETILLO , Samson CHEN , Azita EMAMI
IPC: A61B5/00 , A61B5/145 , A61B5/11 , A61B5/01 , A61B5/1486 , H04B5/00 , A01K1/03 , A01K29/00 , A01K11/00
Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
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公开(公告)号：US20170336340A1
公开(公告)日：2017-11-23
申请号：US15601503
申请日：2017-05-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson CHEN , Axel SCHERER , Muhammad M. JILANI
IPC: G01N27/327
CPC classification number: G01N27/3274
Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
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10.发明申请公开(公告)号：US20130210080A1
公开(公告)日：2013-08-15
申请号：US13763352
申请日：2013-02-08
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya RAJAGOPAL , Samson CHEN , Axel SCHERER , Christopher I. WALKER
CPC classification number: B01L7/52 , B01L3/502707 , B01L2200/147 , B01L2300/0816 , B01L2300/0893 , B01L2300/12 , B01L2300/123 , B01L2300/1827 , B01L2300/1844 , C12Q1/686 , H05K1/0212 , H05K1/0272 , H05K1/028 , H05K3/46 , H05K3/4697 , Y10T29/49124
Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。
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