公开(公告)号：US20210321918A1

公开(公告)日：2021-10-21

申请号：US17314930

申请日：2021-05-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Samson CHEN ,  Axel SCHERER ,  Dvin ADALIAN ,  Peter PETILLO ,  Muhammad Musab JILANI ,  Xiomara L. MADERO ,  Deepan KISHORE KUMAR

IPC: A61B5/1486 ,  C12N11/02 ,  C12N9/02 ,  A61B5/145 ,  A61B5/1459 ,  G01N27/327 ,  C12N11/14

Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

公开(公告)号：US20230121718A1

公开(公告)日：2023-04-20

申请号：US18046737

申请日：2022-10-14

Applicant: California Institute of Technology ,  Gottfried Wilhelm Leibniz Universität Hannover ,  Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Inventor： Oliver PLETTENBURG ,  Christin AHLBRECHT ,  Dvin ADALIAN ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Samson CHEN ,  Muhammad Musab JILANI

IPC: G01N27/327

Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.

公开(公告)号：US20220071529A1

公开(公告)日：2022-03-10

申请号：US17405943

申请日：2021-08-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dvin ADALIAN ,  Samson CHEN ,  Muhammad M. JILANI ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Richard SMITH

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/1473

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

公开(公告)号：US20190307378A1

公开(公告)日：2019-10-10

申请号：US16191357

申请日：2018-11-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dvin ADALIAN ,  Samson CHEN ,  Muhammad M. JILANI ,  Axel SCHERER ,  Xiomara Linnette MADERO ,  Richard SMITH

IPC: A61B5/1486 ,  A61B5/145

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.