公开(公告)号：US12179198B2

公开(公告)日：2024-12-31

申请号：US16475901

申请日：2018-01-05

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Vincent Agache ,  Fabrice Casset ,  Stephane Fanget ,  Yves Fouillet ,  Arnaud Millet

IPC: C12Q1/04 ,  B01L3/00 ,  C12M1/26 ,  G01N15/01 ,  G01N15/10

Abstract: A system for handling biological cells includes a main channel having an inlet end and an outlet end, and, at least over a first portion from the inlet end, including a cross section such that a cell circulating in the portion undergoes mechanical stresses. The system further includes first means for detecting the presence of a cell at the inlet end of the main channel and at least one access zone opening into the main channel between its inlet end and its outlet end in the first portion, in order to make it possible to exert an action on the cell. The system also includes means for displacing the cell in order to control the displacement of the cell between the inlet end and the outlet end.

公开(公告)号：US10564092B2

公开(公告)日：2020-02-18

申请号：US16145806

申请日：2018-09-28

Applicant: Commissariat a l'energie atomique et aux energies alternatives

Inventor： Leopold Virot ,  Vincent Agache ,  Jean-Marc Fedeli ,  Sebastien Hentz

IPC: G01N21/17 ,  G01G17/04 ,  G01N21/25 ,  G02B6/42 ,  H03H9/17

Abstract: The invention is an electromechanical resonator, comprising a fixed portion and an oscillator oscillating at a resonant frequency and comprising a fluidic channel. The channel defines a fluidic circuit, can receive a fluid, and can be deformed at the resonant frequency. The resonator includes a waveguide, defining a photonic circuit, guiding a light wave between an input and an output of the waveguide and being able to be deformed at the resonant frequency. The waveguide input can be connected to a light source and the waveguide output can be connected to a photodetector able to form a signal representative of the light wave propagated by the waveguide towards the photodetector, the light wave being modulated at a frequency dependent on the resonant frequency. A variation in a mass of the fluid, inducing a variation in the resonant frequency, may be detected via the signal formed by the photodetector.

公开(公告)号：US10112827B2

公开(公告)日：2018-10-30

申请号：US15825818

申请日：2017-11-29

Applicant: Commissariat a l'energie atomique et aux energies alternatives

Inventor： Vincent Agache ,  Francois Baleras

IPC: B81C1/00 ,  B81B3/00

Abstract: The invention is a process for producing an electromechanical device including a movable portion that is able to deform with respect to a fixed portion. The process implements steps based on fabrication microtechnologies, applied to a substrate including an upper layer, an intermediate layer and a lower layer. These steps are: a) forming first apertures in the upper layer; b) forming an empty cavity in the intermediate layer, which step is referred to as a pre-release step because a central portion of the upper layer lying between the first apertures is pre-released; c) applying what is called a blocking layer to the upper layer, this layer covering the first apertures, the blocking layer and the central portion together forming a suspended microstructure above the empty cavity; d) producing a boundary trench in the suspended microstructure, so as to form, in this microstructure, a movable portion and a fixed portion, the movable portion forming a movable member of the electromechanical device.

公开(公告)号：US09182268B2

公开(公告)日：2015-11-10

申请号：US13628908

申请日：2012-09-27

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Gerald Blanco-Gomez ,  Vincent Agache

IPC: G01N15/02 ,  G01G3/16 ,  G01N15/14 ,  G01N5/02 ,  G01N15/10

CPC classification number: G01G3/16 ,  G01N5/02 ,  G01N15/02 ,  G01N15/1484 ,  G01N2015/1043

Abstract: The invention relates to a device for mass detection of particles in a fluid medium, including an electromechanical oscillator (7), excitation means (9) fitted so as to cause the said oscillator to vibrate, a fluid supply circuit (5), and a fluid system (11) incorporated in the said oscillator, where the said fluid system (11) is in fluid communication with the fluid supply circuit (5), where the said fluid system (11) includes at least one trapping site (21) configured to trap a particle of interest according to the size of the said particle of interest.

Abstract translation: 本发明涉及一种用于质量检测流体介质中的颗粒的装置，包括机电振荡器（7），安装成使振荡器振动的激励装置（9），流体供应电路（5）和 流体系统（11），其结合在所述振荡器中，其中所述流体系统（11）与所述流体供应回路（5）流体连通，其中所述流体系统（11）包括至少一个捕集部位（21） 以根据所述感兴趣的颗粒的大小捕获感兴趣的颗粒。

公开(公告)号：US20190101488A1

公开(公告)日：2019-04-04

申请号：US16145806

申请日：2018-09-28

Applicant: Commissariat a l'energie atomique et aux energies alternatives

Inventor： Leopold Virot ,  Vincent Agache ,  Jean-Marc Fedeli ,  Sebastien Hentz

IPC: G01N21/17 ,  G02B6/42 ,  H03H9/17 ,  G01N21/25 ,  G01G17/04

CPC classification number: G01N21/1717 ,  G01G17/04 ,  G01N21/255 ,  G02B6/42 ,  H03H9/17

Abstract: The invention is an electromechanical resonator, comprising a fixed portion (10) and an oscillator (20, 60), the oscillator being able to oscillate at a resonant frequency (f), the oscillator comprising: a fluidic channel (25), defining a fluidic circuit, produced in the oscillator (20, 60), and intended to receive a fluid (4), the fluidic channel being able to be deformed at the resonant frequency, under the effect of the oscillation of the oscillator; the resonator being characterized in that it also includes: a waveguide (26), defining a photonic circuit, produced in the oscillator (20, 60), and intended to guide a light wave (7) between an input (26in) and an output (26out) of the waveguide, the waveguide (26) being able to be deformed at the resonant frequency (f), under the effect of the oscillation of the oscillator; the input (26in) of the waveguide being able to be connected to a light source (6), the output of the waveguide being able to be connected to a photodetector (8), so that the photodetector is able to form a signal (S) representative of the light wave propagated by the waveguide towards the photodetector, the light wave being modulated at a modulation frequency (w) dependent on the resonant frequency (f); such that when under the effect of a variation (δm) in a mass (m) of the fluid (4), inducing a variation (δf) in the resonant frequency, the variation (δm) in mass may be detected via the signal formed by the photodetector.

公开(公告)号：US20130112559A1

公开(公告)日：2013-05-09

申请号：US13645755

申请日：2012-10-05

Applicant: Commissariat A L'Energie Atomique Et Aux Energies Alternatives

Inventor： Raphael RENAUDOT ,  Vincent Agache

IPC: B81B1/00

CPC classification number: B01L3/502792 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0415

Abstract: The invention relates to a microfluidic device and a method for handling at least one drop.The device comprises first and second microfluidic surfaces (3a, 3b) parallel and separated from each other by a separation distance (H), at least one first electrical displacement path (5a) arranged on said first surface (3a), and at least one second electrical displacement path (5b) arranged on said second surface (3b). The at least one of the first and second paths is configured in order to form a respective fluidic finger along said path, said fluidic finger rupturing via capillarity, by generating at least one respective drop. The first and second paths are configured so that said separation distance between said first and second surfaces is on the one hand, greater than the fluidic thickness formed by each fluidic finger and, on the other hand, less than the fluidic thickness formed by each drop.

Abstract translation: 本发明涉及一种用于处理至少一滴的微流体装置和方法。 所述装置包括彼此平行和分开间隔距离（H）的第一和第二微流体表面（3a，3b），布置在所述第一表面（3a）上的至少一个第一电位移路径（5a）和至少一个 布置在所述第二表面（3b）上的第二电位移路径（5b）。 第一和第二路径中的至少一个被配置成沿着所述路径形成相应的流体指状物，所述流体指通过毛细管力破裂，通过产生至少一个相应的液滴。 第一和第二路径构造成使得所述第一和第二表面之间的所述分离距离一方面大于由每个流体指形成的流体厚度，另一方面小于由每个液滴形成的流体厚度 。