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公开(公告)号：US06232071B1
公开(公告)日：2001-05-15
申请号：US09364902
申请日：1999-07-29
申请人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
发明人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
IPC分类号： C12Q168
CPC分类号： C12N15/115 , A61K38/00 , A61K47/54 , A61K47/547 , A61K47/549 , A61K2123/00 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N2310/13 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/53 , C12Q1/37 , C12Q1/6883 , C12Q2541/101 , C12Q2600/158 , C40B40/00 , F02B2075/027 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12N2310/3521
摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.
摘要翻译： 描述了用于鉴定和制备腱生蛋白-C的核酸配体的方法。 包括在本发明中的是通过SELEX方法鉴定的腱生蛋白-C的特异性RNA配体。 本发明还包括用于检测生物组织中存在腱生蛋白-C的疾病状况的方法。
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公开(公告)号：US07005260B1
公开(公告)日：2006-02-28
申请号：US10031193
申请日：2000-01-28
申请人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
发明人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.
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公开(公告)号：US06596491B2
公开(公告)日：2003-07-22
申请号：US09854662
申请日：2001-05-14
申请人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
发明人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
IPC分类号： C12Q168
CPC分类号： C12N15/115 , A61K38/00 , A61K47/54 , A61K47/547 , A61K47/549 , A61K2123/00 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N2310/13 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/53 , C12Q1/37 , C12Q1/6883 , C12Q2541/101 , C12Q2600/158 , C40B40/00 , F02B2075/027 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12N2310/3521
摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.
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公开(公告)号：US20060105378A1
公开(公告)日：2006-05-18
申请号：US11300662
申请日：2005-12-13
申请人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
发明人： Brian Hicke , Stephen Warren , David Parma , Larry Gold
CPC分类号： C12N15/115 , A61K38/00 , A61K47/54 , A61K47/547 , A61K47/549 , A61K2123/00 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N2310/13 , C12N2310/317 , C12N2310/3183 , C12N2310/321 , C12N2310/322 , C12N2310/3517 , C12N2310/53 , C12Q1/37 , C12Q1/6883 , C12Q2541/101 , C12Q2600/158 , C40B40/00 , F02B2075/027 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12N2310/3521
摘要： Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method. Further included in the invention are methods for detecting the presence of a disease condition in a biological tissue in which tenascin-C is expressed.
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公开(公告)号：US20090118481A1
公开(公告)日：2009-05-07
申请号：US12133132
申请日：2008-06-04
申请人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
发明人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
IPC分类号： C07H21/00
CPC分类号： C07H19/10 , C07H19/06 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6804 , C12Q1/6811 , C12Q1/70 , C40B40/00 , F02B2075/027 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , G01N2333/163 , G01N2333/4724 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/966 , G01N2333/974 , C12Q2525/101
摘要： This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands. This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
摘要翻译： 本发明公开了具有凝集素的高亲和力寡核苷酸配体，特别是具有与凝集素结合的能力的核酸配体，小麦胚芽凝集素，L-选择蛋白，E-选择蛋白和P-选择蛋白。 还公开了获得这种配体的方法。 本发明公开了具有凝集素的高亲和力寡核苷酸配体，特别是具有与凝集素结合的能力的核酸配体，小麦胚芽凝集素，L-选择蛋白，E-选择蛋白和P-选择蛋白。 还公开了获得这种配体的方法。
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公开(公告)号：US06544959B1
公开(公告)日：2003-04-08
申请号：US09849928
申请日：2001-05-04
申请人： David H Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
发明人： David H Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
IPC分类号： A01N6100
CPC分类号： G01N33/76 , A61K47/547 , A61K47/549 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N15/115 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6804 , C12Q1/6811 , C12Q1/70 , C40B40/00 , F02B2075/027 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N2333/163 , G01N2333/4724 , G01N2333/575 , G01N2333/62 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2525/101
摘要： This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
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公开(公告)号：US5780228A
公开(公告)日：1998-07-14
申请号：US479724
申请日：1995-06-07
申请人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
发明人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
IPC分类号： A61K38/00 , C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K7/22 , C07K14/00 , C07K14/16 , C07K14/72 , C12N9/12 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , C12Q1/70 , F02B75/02 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07H19/00 , C07H21/02
CPC分类号： A61K47/48092 , A61K47/48076 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C07K14/005 , C07K14/72 , C07K7/22 , C12N15/1048 , C12N15/115 , C12N9/1276 , C12Q1/37 , C12Q1/6811 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/6842 , G01N33/76 , A61K38/00 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12N2740/16222 , C40B40/00 , F02B2075/027 , G01N2333/16 , G01N2333/163 , G01N2333/503 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/918 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976
摘要： This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
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公开(公告)号：US07399752B2
公开(公告)日：2008-07-15
申请号：US10409627
申请日：2003-04-07
申请人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
发明人： David H. Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
CPC分类号： G01N33/76 , A61K47/547 , A61K47/549 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N15/115 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6804 , C12Q1/6811 , C12Q1/70 , C40B40/00 , F02B2075/027 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N2333/163 , G01N2333/4724 , G01N2333/575 , G01N2333/62 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2525/101
摘要： This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
摘要翻译： 本发明公开了具有凝集素的高亲和力寡核苷酸配体，特别是具有与凝集素结合的能力的核酸配体，小麦胚芽凝集素，L-选择蛋白，E-选择蛋白和P-选择蛋白。 还公开了获得这种配体的方法。
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公开(公告)号：US06280932B1
公开(公告)日：2001-08-28
申请号：US08952793
申请日：1997-11-21
申请人： David H Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
发明人： David H Parma , Brian Hicke , Philippe Bridonneau , Larry Gold
IPC分类号： C12Q168
CPC分类号： G01N33/76 , A61K47/547 , A61K47/549 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N9/1276 , C12N15/1048 , C12N15/115 , C12N2310/13 , C12N2310/322 , C12N2310/53 , C12Q1/37 , C12Q1/6804 , C12Q1/6811 , C12Q1/70 , C40B40/00 , F02B2075/027 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N2333/163 , G01N2333/4724 , G01N2333/575 , G01N2333/62 , G01N2333/7056 , G01N2333/8125 , G01N2333/96433 , G01N2333/96455 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , C12Q2525/101
摘要： This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin and P-selectin. Also disclosed are the methods for obtaining such ligands.
摘要翻译： 本发明公开了具有凝集素的高亲和力寡核苷酸配体，特别是具有与凝集素结合的能力的核酸配体，小麦胚芽凝集素，L-选择蛋白和P-选择蛋白。 还公开了获得这种配体的方法。
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公开(公告)号：US20050158780A1
公开(公告)日：2005-07-21
申请号：US11029949
申请日：2005-01-04
申请人： Shawn Lupold , Yun Lin , Brian Hicke , Donald Coffey
发明人： Shawn Lupold , Yun Lin , Brian Hicke , Donald Coffey
IPC分类号： C12N15/09 , A61K47/48 , A61K51/00 , A61P35/00 , C07K14/705 , C07K17/02 , C12N15/115 , C12Q1/68 , C07F5/00 , C07H21/02
CPC分类号： C12Q1/6886 , C07K14/705 , C12N15/115 , C12N2310/322
摘要： Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ligands to PSMA, and methods and compositions for the treatment and diagnosis of disease using the nucleic acid ligands.
摘要翻译： 提供了用于产生前列腺特异性膜抗原（PSMA）的核酸配体的方法。 本发明的方法使用SELEX方法分离核酸配体。 本发明还包括PSMA的核酸配体，以及使用核酸配体治疗和诊断疾病的方法和组合物。
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