公开(公告)号：US20170307592A1

公开(公告)日：2017-10-26

申请号：US15589302

申请日：2017-05-08

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Joseph M. Ready ,  Andrew A. Pieper ,  Gelin Wang ,  Ting Han

IPC分类号： G01N33/50 ,  C12Q1/48 ,  A61K38/00

CPC分类号： G01N33/5058 ,  A61K38/00 ,  C12Q1/48 ,  G01N33/5014 ,  G01N33/5038 ,  G01N2333/91142

摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.

公开(公告)号：US20160206594A1

公开(公告)日：2016-07-21

申请号：US14996596

申请日：2016-01-15

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Joseph M. Ready ,  Andrew A. Pieper ,  Jef K. De Brabander

IPC分类号： A61K31/403 ,  A61K31/422 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/4192 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/437

CPC分类号： A61K31/403 ,  A61K31/00 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/506 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D209/08 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04

摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.

公开(公告)号：US08686012B2

公开(公告)日：2014-04-01

申请号：US13674710

申请日：2012-11-12

申请人： The Board of Regents of the University of Texas System

发明人： Eric N. Olson ,  Douglas Frantz ,  Jenny Hsieh ,  Steven L. McKnight ,  Jay Schneider

IPC分类号： A61K31/4155 ,  A61K31/422

CPC分类号： C07D413/04 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/42 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377 ,  C07C311/49 ,  C07D231/12 ,  C07D261/08 ,  C07D261/18 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C12N5/0618 ,  C12N5/0657 ,  C12N2501/999

摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.

摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。

公开(公告)号：US20130184271A1

公开(公告)日：2013-07-18

申请号：US13770706

申请日：2013-02-19

申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Steven L. McKnight ,  Andrew A. Pieper ,  Joseph M. Ready ,  Jef K. De Brabander

IPC分类号： C07D487/04 ,  C07D401/06 ,  C07D403/12 ,  C07D209/08 ,  C07D471/04 ,  C07D209/88 ,  C07D413/06

CPC分类号： A61K31/403 ,  A61K31/4439 ,  C07D209/08 ,  C07D209/56 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022

摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

摘要翻译： 该技术一般涉及用于刺激神经发生（例如产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 本文公开了各种化合物。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。

公开(公告)号：US10183011B2

公开(公告)日：2019-01-22

申请号：US15440396

申请日：2017-02-23

申请人： Board of Regents of the University of Texas System

发明人： Steven L. McKnight ,  Andrew A. Pieper ,  Joseph M. Ready ,  Jef K. De Brabander ,  Jeffrey M. Zigman

IPC分类号： A61K31/4045 ,  C07D209/04 ,  C07D209/82 ,  C07D401/06 ,  C07D413/06 ,  C07D471/04 ,  C07D403/12 ,  C07D403/06 ,  C07F5/02 ,  C07D487/04 ,  A61K31/44 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4425 ,  A61K31/506 ,  C07D413/14 ,  C07D401/12 ,  C07D403/14 ,  C07D407/06 ,  C07D209/88 ,  C07D405/12 ,  C07D495/04 ,  C07D209/08 ,  C07D209/86 ,  C07F7/08 ,  A61K31/4188 ,  A61K31/41 ,  A61K31/429 ,  A61K31/5377 ,  A61K31/69

摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

公开(公告)号：US20180318255A1

公开(公告)日：2018-11-08

申请号：US15966076

申请日：2018-04-30

申请人： Board of Regents of the University of Texas System

发明人： Steven L. McKnight ,  Andrew A. Pieper ,  Joseph M. Ready ,  Jef K. De Brabander

IPC分类号： A61K31/403 ,  A61K31/4439 ,  C07D403/12 ,  C07D209/56 ,  C07D487/04 ,  C07F5/02 ,  C07D209/88 ,  C07D209/86 ,  C07D209/08 ,  C07D495/04 ,  C07D471/04 ,  C07D413/06 ,  C07D405/12 ,  C07D403/06 ,  C07D401/12 ,  C07D401/06

CPC分类号： A61K31/403 ,  A61K31/4439 ,  C07D209/08 ,  C07D209/56 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022

摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

公开(公告)号：US09616048B2

公开(公告)日：2017-04-11

申请号：US14886332

申请日：2015-10-19

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Andew A. Pieper ,  Joseph M. Ready ,  Jef K. De Brabander ,  Jeffrey M. Zigman

IPC分类号： A61K31/44 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/4045 ,  C07D209/04 ,  C07D209/82 ,  C07D401/06 ,  C07D413/06 ,  C07D471/04 ,  C07D403/12 ,  C07D403/06 ,  C07F5/02 ,  C07D487/04 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4425 ,  A61K31/506 ,  C07D413/14 ,  C07D401/12 ,  C07D403/14 ,  C07D407/06 ,  C07D209/88 ,  C07D405/12 ,  C07D495/04 ,  C07D209/08 ,  C07D209/86 ,  C07F7/08 ,  A61K31/4188

CPC分类号： A61K31/4045 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/429 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4425 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/69 ,  C07D209/04 ,  C07D209/08 ,  C07D209/82 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/06 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022 ,  C07F7/0812

摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

公开(公告)号：US20170030897A1

公开(公告)日：2017-02-02

申请号：US14945629

申请日：2015-11-19

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Joseph M. Ready ,  Andrew A. Pieper ,  Gelin Wang ,  Ting Han

IPC分类号： G01N33/50

CPC分类号： G01N33/5058 ,  A61K38/00 ,  C12Q1/48 ,  G01N33/5014 ,  G01N33/5038 ,  G01N2333/91142

摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.

摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。

公开(公告)号：US09278923B2

公开(公告)日：2016-03-08

申请号：US14100515

申请日：2013-12-09

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Joseph M. Ready ,  Andrew A. Pieper ,  Jef K. De Brabander

IPC分类号： A61K31/403 ,  C07D209/08 ,  A61K31/00 ,  A61K31/415 ,  A61K31/437 ,  A61K31/44 ,  A61K31/506 ,  C07D209/86 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D209/88 ,  C07D401/12

CPC分类号： A61K31/403 ,  A61K31/00 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/506 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07D209/08 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04

摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death.

公开(公告)号：US09162980B2

公开(公告)日：2015-10-20

申请号：US14339772

申请日：2014-07-24

申请人： Board of Regents of The University of Texas System

发明人： Steven L. McKnight ,  Andew A. Pieper ,  Joseph M. Ready ,  Jef K. De Brabander ,  Jeffrey M. Zigman

IPC分类号： A61K31/403 ,  A61K31/44 ,  C07D209/04 ,  C07D209/82 ,  C07D401/06 ,  C07D413/06 ,  C07D471/04 ,  C07D403/12 ,  C07D403/06 ,  C07F5/02 ,  C07D487/04 ,  A61K31/4439 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4425 ,  A61K31/506 ,  C07D413/14 ,  C07D401/12 ,  C07D403/14 ,  C07D407/06 ,  C07D209/88 ,  C07D405/12 ,  C07D495/04 ,  C07D209/08 ,  C07D209/86 ,  C07F7/08

CPC分类号： A61K31/4045 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/429 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4425 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/69 ,  C07D209/04 ,  C07D209/08 ,  C07D209/82 ,  C07D209/86 ,  C07D209/88 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/06 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07F5/022 ,  C07F7/0812

摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

摘要翻译： 该技术一般涉及用于刺激神经发生（例如产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 本文公开了各种化合物。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。