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公开(公告)号：US20170307592A1
公开(公告)日：2017-10-26
申请号：US15589302
申请日：2017-05-08
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
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公开(公告)号：US09789096B2
公开(公告)日：2017-10-17
申请号：US14916644
申请日：2014-09-04
IPC分类号： A61K31/428 , A61K31/426 , C07C235/88 , C07D333/70 , C07D409/12 , C07D417/12 , C07D513/04 , C12N9/99 , A61K31/381 , C07D405/14 , C07D213/75 , C07D215/48 , C07D217/02 , C07D405/12 , C07D409/14 , C07D239/90 , C07D417/14 , C07D209/08 , C07D277/82 , C07D209/44 , C07C271/44 , C07C271/46 , C07C271/48 , C07C275/24 , C07C275/30 , C07C275/54 , C07C233/56 , C07C233/73 , C07C235/38 , C07C235/56 , C07C235/66 , C07C235/70 , C07C237/08
CPC分类号： A61K31/426 , A61K31/381 , A61K31/428 , C07C233/56 , C07C233/73 , C07C235/38 , C07C235/56 , C07C235/66 , C07C235/70 , C07C235/88 , C07C237/08 , C07C271/44 , C07C271/46 , C07C271/48 , C07C275/24 , C07C275/30 , C07C275/54 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/26 , C07D209/08 , C07D209/44 , C07D213/75 , C07D215/48 , C07D217/02 , C07D239/90 , C07D277/82 , C07D333/70 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04 , C12N9/99
摘要： Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
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公开(公告)号：US20160206594A1
公开(公告)日：2016-07-21
申请号：US14996596
申请日：2016-01-15
IPC分类号： A61K31/403 , A61K31/422 , A61K31/4155 , A61K31/506 , A61K31/4192 , A61K31/404 , A61K31/4439 , A61K31/437
CPC分类号： A61K31/403 , A61K31/00 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/506 , A61P25/16 , A61P25/18 , A61P25/28 , C07D209/08 , C07D209/86 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
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公开(公告)号：US20160200695A1
公开(公告)日：2016-07-14
申请号：US14916644
申请日：2014-09-04
IPC分类号： C07D277/82 , C07D417/12 , C12N9/99 , C07D513/04 , C07D405/12 , C07C235/88 , C07D333/70 , C07D409/12
CPC分类号： A61K31/426 , A61K31/381 , A61K31/428 , C07C233/56 , C07C233/73 , C07C235/38 , C07C235/56 , C07C235/66 , C07C235/70 , C07C235/88 , C07C237/08 , C07C271/44 , C07C271/46 , C07C271/48 , C07C275/24 , C07C275/30 , C07C275/54 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/26 , C07D209/08 , C07D209/44 , C07D213/75 , C07D215/48 , C07D217/02 , C07D239/90 , C07D277/82 , C07D333/70 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04 , C12N9/99
摘要： Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
摘要翻译： 本文提供了用于选择性和靶向癌症治疗的方法和组合物，特别是某些苯并噻吩，苯并噻唑，草酰胺，N-酰基脲和色酮，以及它们在选择性治疗某些腺癌中的用途。 在一些实施方案中，化合物的选择性毒性可以通过SCD1和/或CYP450如CYP4F11介导。
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5.发明申请Methods for Treating Parkinson's Disease Using Pro-Neurogenic Compounds 有权使用Pro-Neurogenic化合物治疗帕金森病的方法公开(公告)号：US20130184271A1
公开(公告)日：2013-07-18
申请号：US13770706
申请日：2013-02-19
IPC分类号： C07D487/04 , C07D401/06 , C07D403/12 , C07D209/08 , C07D471/04 , C07D209/88 , C07D413/06
CPC分类号： A61K31/403 , A61K31/4439 , C07D209/08 , C07D209/56 , C07D209/86 , C07D209/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07F5/022
摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
摘要翻译： 该技术一般涉及用于刺激神经发生（例如产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 本文公开了各种化合物。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。
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公开(公告)号：US20190135809A1
公开(公告)日：2019-05-09
申请号：US16180238
申请日：2018-11-05
IPC分类号： C07D471/04 , A61K31/519 , A61K31/403 , A61K31/55 , C07D223/24 , C07D405/06 , C07D209/90 , C07D487/04 , C07D403/06
摘要： Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
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公开(公告)号：US09701676B2
公开(公告)日：2017-07-11
申请号：US13974642
申请日：2013-08-23
IPC分类号： A61K31/403 , C07D209/82 , C07D209/86 , C07D209/88 , C07D471/04 , C07D223/24 , C07D487/04 , C07D209/90 , C07D405/06 , C07D403/06 , A61K31/55 , A61K31/519
CPC分类号： C07D471/04 , A61K31/403 , A61K31/519 , A61K31/55 , C07D209/90 , C07D223/24 , C07D403/06 , C07D405/06 , C07D487/04
摘要： Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
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公开(公告)号：US20160074361A1
公开(公告)日：2016-03-17
申请号：US14790313
申请日：2015-07-02
IPC分类号： A61K31/403 , A61K31/422 , A61K31/4188 , A61K31/404 , A61K31/4192 , A61K31/4155 , A61K31/4439 , A61K31/506
CPC分类号： C07D209/88 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/08 , C07D209/82 , C07D209/86 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04 , C07D495/04 , C07F5/022
摘要： This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
摘要翻译： 该技术一般涉及用于刺激神经发生（例如产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 本文公开了各种化合物。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。
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公开(公告)号：US20150290195A1
公开(公告)日：2015-10-15
申请号：US14750119
申请日：2015-06-25
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/422 , A61K31/4035 , A61K31/437 , A61K31/404 , A61K31/4192 , A61K31/4155 , A61K31/403 , A61K31/4045
CPC分类号： C07D209/88 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/08 , C07D209/14 , C07D209/86 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D471/04
摘要： This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.
摘要翻译： 本发明一般涉及刺激神经发生（例如，产后神经发生，例如产后海马神经发生）和保护神经元细胞死亡。
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公开(公告)号：US20150132783A1
公开(公告)日：2015-05-14
申请号：US14540006
申请日：2014-11-12
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
IPC分类号： C12Q1/48
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。
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