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公开(公告)号：US20170307592A1
公开(公告)日：2017-10-26
申请号：US15589302
申请日：2017-05-08
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
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公开(公告)号：US20170030897A1
公开(公告)日：2017-02-02
申请号：US14945629
申请日：2015-11-19
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。
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公开(公告)号：US20180140578A1
公开(公告)日：2018-05-24
申请号：US15821111
申请日：2017-11-22
发明人： Deepak Nijhawan , Ting Han , Nicholas H. Gaskill
IPC分类号： A61K31/404 , A61K31/381 , A61K31/498 , A61P35/00 , G01N33/574
CPC分类号： A61K31/404 , A61K31/381 , A61K31/498 , A61P35/00 , C12Q1/6886 , G01N33/57484
摘要： In one aspect, provided herein are methods for treating cancer in a subject, comprising: (1) identifying in the subject the presence of a mutation in a splicing factor selected from the group consisting of U2AF1, SF3B1, SRSF2, and ZRSR2; and/or determining in the subject an increased amount of DCAF15 compared to a control, and (2) inhibiting an activity of RBM39 in the subject. In some embodiments, the inhibiting step can include promoting RBM39 degradation, preferably in a DCAF15-dependent manner. Compositions are also provided.
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公开(公告)号：US09645139B2
公开(公告)日：2017-05-09
申请号：US14945629
申请日：2015-11-19
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
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公开(公告)号：US09243281B2
公开(公告)日：2016-01-26
申请号：US14540006
申请日：2014-11-12
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。
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公开(公告)号：US20150132783A1
公开(公告)日：2015-05-14
申请号：US14540006
申请日：2014-11-12
发明人： Steven L. McKnight , Joseph M. Ready , Andrew A. Pieper , Gelin Wang , Ting Han
IPC分类号： C12Q1/48
CPC分类号： G01N33/5058 , A61K38/00 , C12Q1/48 , G01N33/5014 , G01N33/5038 , G01N2333/91142
摘要： Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.
摘要翻译： 本文提供了鉴定具有细胞保护（例如神经保护）活性的化合物的方法。 还提供了从其鉴定的化合物。 这些化合物可用于治疗与例如不想要的细胞死亡有关的各种疾病，病症或病症。
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