专利检索 ap:("Board of Regents of the University of Texas System") AND inv:"Nicholas H. Gaskill" 第 1 页

1.

发明申请
METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND SELECTIVE TREATMENT OF CANCER 审中-公开

公开(公告)号：US20180140578A1

公开(公告)日：2018-05-24

申请号：US15821111

申请日：2017-11-22

申请人： Board of Regents of the University of Texas System

发明人： Deepak Nijhawan , Ting Han , Nicholas H. Gaskill

IPC分类号： A61K31/404 , A61K31/381 , A61K31/498 , A61P35/00 , G01N33/574

CPC分类号： A61K31/404 , A61K31/381 , A61K31/498 , A61P35/00 , C12Q1/6886 , G01N33/57484

摘要： In one aspect, provided herein are methods for treating cancer in a subject, comprising: (1) identifying in the subject the presence of a mutation in a splicing factor selected from the group consisting of U2AF1, SF3B1, SRSF2, and ZRSR2; and/or determining in the subject an increased amount of DCAF15 compared to a control, and (2) inhibiting an activity of RBM39 in the subject. In some embodiments, the inhibiting step can include promoting RBM39 degradation, preferably in a DCAF15-dependent manner. Compositions are also provided.