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公开(公告)号：US08686012B2
公开(公告)日：2014-04-01
申请号：US13674710
申请日：2012-11-12
IPC分类号： A61K31/4155 , A61K31/422
CPC分类号： C07D413/04 , A61K31/415 , A61K31/4155 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/5377 , C07C311/49 , C07D231/12 , C07D261/08 , C07D261/18 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C12N5/0618 , C12N5/0657 , C12N2501/999
摘要： The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
摘要翻译： 本发明涉及可诱导干细胞分化的化合物的筛选。 此外，异恶唑和磺酰腙被鉴定为可以分别诱导干细胞分化为神经元和心脏命运细胞的化合物的一般类别。
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公开(公告)号：US11111278B2
公开(公告)日：2021-09-07
申请号：US16743831
申请日：2020-01-15
摘要： The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
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公开(公告)号：US11166949B2
公开(公告)日：2021-11-09
申请号：US16096536
申请日：2017-04-26
IPC分类号： A61K31/47 , A61P3/04 , A61K31/4706 , A61K38/28 , A61K45/06 , A61K31/437 , A61K38/22 , A61P1/16
摘要： The present disclosure relates to the identification of Nurr1 as a key regulator of metabolism, and the use of Nurr1 agonist to treat metabolic disorders such as diabetes, obesity, metabolic syndrome and hepatic steatosis.
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公开(公告)号：US09937156B2
公开(公告)日：2018-04-10
申请号：US15029222
申请日：2014-10-16
发明人： Eric M. Small , Eric N. Olson
IPC分类号： A61K31/42 , A61K45/06 , A61F13/00 , A61G10/02 , A61K9/06 , A61K9/08 , A61K9/14 , A61L17/00 , A61L17/06 , A61M1/00 , A61N1/04 , A61N5/06 , A61N7/00 , C07K16/18 , C12N15/113 , A61L15/44 , A61L26/00
CPC分类号： A61K31/42 , A61F13/00021 , A61G10/026 , A61K9/06 , A61K9/08 , A61K9/14 , A61K45/06 , A61L15/44 , A61L17/005 , A61L17/06 , A61L26/0066 , A61L2300/204 , A61L2300/412 , A61M1/0088 , A61N1/0468 , A61N5/062 , A61N7/00 , C07K16/18 , C12N15/113
摘要： The present disclosure concerns uses for isoxazole compounds or salts or analogs thereof for the treatment of wounds. The present disclosure also concerns devices for delivering a isoxazole compound or salts or an analogs thereof to a wound site.
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公开(公告)号：US20170298107A1
公开(公告)日：2017-10-19
申请号：US15491057
申请日：2017-04-19
CPC分类号： C07K14/47 , A61K38/1709 , A61K45/06
摘要： The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
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公开(公告)号：US09523079B2
公开(公告)日：2016-12-20
申请号：US14697955
申请日：2015-04-28
发明人： Young-Jae Nam , Kunhua Song , Eric N. Olson
IPC分类号： A61K48/00 , C12N5/071 , A61P9/00 , C12N5/077 , C07K14/47 , A61K31/7105 , A61K38/17 , A61K45/06 , A61K38/00
CPC分类号： C12N5/0657 , A61K31/7105 , A61K38/00 , A61K38/17 , A61K45/06 , C07K14/4702 , C12N2501/40 , C12N2770/00043
摘要： The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.
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公开(公告)号：US10570183B2
公开(公告)日：2020-02-25
申请号：US15491057
申请日：2017-04-19
摘要： The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
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