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公开(公告)号：US20210040239A1
公开(公告)日：2021-02-11
申请号：US16968201
申请日：2019-02-14
Applicant: Biological E Limited
Inventor： Vamsee Krishna Chintakunta , Manohar Sarma Vedula , Narender Dev Mantena , Rajasekhar Kadaboina
Abstract: The present invention provides an improved process for the preparation of Dalteparin sodium. The process is simple, commercially viable and industrially advantageous.
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2.发明申请公开(公告)号：US20180155453A1
公开(公告)日：2018-06-07
申请号：US15568558
申请日：2016-04-25
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Vivek Babu Kandimalla , Narender Dev Mantena , Mahima Datla , Muthyala Venkateswara Reddy , Kantam Charan
CPC classification number: C08B37/0003 , A61K39/00 , A61K39/092 , C12P19/04 , Y02A50/484
Abstract: The invention relates to a method for the removal of protein and other impurities from microbial capsular polysaccharides. More particularly, the present invention relates to isolation of microbial capsular polysaccharides in pure form after removal of protein and other impurities.
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3.发明授权公开(公告)号：US11547752B2
公开(公告)日：2023-01-10
申请号：US16369933
申请日：2019-03-29
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Rajan Sriraman , Deviprasanna Chakka , Satyam Naidu Sureddi , Rajendar Burki , Sreenivasa Rao Ganti , Narender Dev Mantena , Mahima Datla
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K9/00 , A61K39/00
Abstract: The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
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公开(公告)号：US11147863B2
公开(公告)日：2021-10-19
申请号：US15772771
申请日：2016-06-21
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Nagarajan Thirumeni , Rajendar Burki , Narender Dev Mantena , Mahima Datla
Abstract: The present invention relates to a multivalent Pneumococcal conjugate vaccine (PCV) composition comprising: 1) at least 12 capsular polysaccharides selected from serotypes 1, 3, 4, 5, 6B, 7F, 9N, 9V, 15B, 14, 18C, 19A, 19F, 22F, 23F and 33F of S. pneumoniae activated with CDAP and conjugated to carrier protein selected from CRM197, pneumococcal surface protein A (PspA), pneumococcal adhesin protein (PsaA) or combination thereof and 2) a pharmaceutically acceptable carrier, wherein the composition does not contain capsular polysaccharide from serotype 6A.
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公开(公告)号：US20210189019A1
公开(公告)日：2021-06-24
申请号：US16771098
申请日：2018-12-11
Applicant: Biological E Limited
IPC: C08B37/00
Abstract: The present invention provides an improved process for the preparation of Enoxaparin sodium. The process is simple, commercially viable and industrially advantageous.
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Patent Agency Ranking
公开(公告)号：US20200277341A1
公开(公告)日：2020-09-03
申请号：US16606958
申请日：2018-04-19
Applicant: Biological E Limited
Inventor： Balamurali Masilamani , Rajan Sriraman , Mandar Shirish Dixit , Deviprasanna Chakka , Satyam Naidu Sureddi , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla
IPC: C07K14/34 , C12N1/20 , C12P21/00 , A61K39/05 , A61K39/385
Abstract: The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.
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7.发明申请公开(公告)号：US20190224295A1
公开(公告)日：2019-07-25
申请号：US16369933
申请日：2019-03-29
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Rajan Sriraman , Deviprasanna Chakka , Satyam Naidu Sureddi , Rajendar Burki , Sreenivasa Rao Ganti , Narender Dev Mantena , Mahima Datla
Abstract: The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
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公开(公告)号：US12048739B2
公开(公告)日：2024-07-30
申请号：US17278181
申请日：2019-09-23
Applicant: Biological E Limited
Inventor： Rajendar Burki , Vivek Babu Kandimalla , Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Veerapandu Sangareddy
CPC classification number: A61K39/092 , A61K31/715 , A61K47/62 , C08B37/0003 , A61K2039/6037 , A61K2039/70
Abstract: The invention relates to capsular polysaccharides of Streptococcus pneumoniae. More specifically, the present invention relates to sized and purified capsular polysaccharides of Streptococcus pneumoniae serotypes 2, 15A, 15C & 35B and process for their preparation.
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公开(公告)号：US20230322871A1
公开(公告)日：2023-10-12
申请号：US18338584
申请日：2023-06-21
Applicant: Biological E Limited
Inventor： Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Swetha Kamireddy
IPC: C07K14/315 , A61K39/09 , C12N15/77 , A61K47/64 , A61K39/116
CPC classification number: C07K14/3156 , A61K39/092 , C12N15/77 , A61K47/646 , A61K39/116 , A61K2039/6068
Abstract: The present invention relates to expression of Pneumococcal Surface Protein A (PspA). The invention represents an advancement in the field of genetic engineering and vaccine technology. The invention discloses expression vectors and recombinant host cells for expression of truncated PspA peptide. The invention also discloses vaccine compositions comprising the truncated peptides as carrier protein.
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公开(公告)号：US11299558B2
公开(公告)日：2022-04-12
申请号：US16771098
申请日：2018-12-11
Applicant: Biological E Limited
IPC: C08B37/00
Abstract: The present invention provides an improved process for the preparation of Enoxaparin sodium. The process is simple, commercially viable and industrially advantageous.
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