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1.发明授权公开(公告)号：US11547752B2
公开(公告)日：2023-01-10
申请号：US16369933
申请日：2019-03-29
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Rajan Sriraman , Deviprasanna Chakka , Satyam Naidu Sureddi , Rajendar Burki , Sreenivasa Rao Ganti , Narender Dev Mantena , Mahima Datla
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K9/00 , A61K39/00
Abstract: The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
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公开(公告)号：US20200277341A1
公开(公告)日：2020-09-03
申请号：US16606958
申请日：2018-04-19
Applicant: Biological E Limited
Inventor： Balamurali Masilamani , Rajan Sriraman , Mandar Shirish Dixit , Deviprasanna Chakka , Satyam Naidu Sureddi , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla
IPC: C07K14/34 , C12N1/20 , C12P21/00 , A61K39/05 , A61K39/385
Abstract: The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.
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3.发明申请公开(公告)号：US20190224295A1
公开(公告)日：2019-07-25
申请号：US16369933
申请日：2019-03-29
Applicant: BIOLOGICAL E LIMITED
Inventor： Ramesh Venkat Matur , Rajan Sriraman , Deviprasanna Chakka , Satyam Naidu Sureddi , Rajendar Burki , Sreenivasa Rao Ganti , Narender Dev Mantena , Mahima Datla
Abstract: The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.
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公开(公告)号：US20210322533A1
公开(公告)日：2021-10-21
申请号：US17261345
申请日：2019-07-19
Applicant: Biological E Limited
Inventor： Veerapandu Sangareddy , Rajendar Burki , Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla
IPC: A61K39/09
Abstract: The present invention relates to vaccine formulations comprising preservative systems. More particularly, the present invention relates to preservative systems for vaccine formulations which is free of thiomersal, and comprising 2-phenoxyethanol and at least one other preservative selected from m-cresol, benzyl alcohol, phenol and benzoic acid.
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公开(公告)号：US11098089B2
公开(公告)日：2021-08-24
申请号：US16606958
申请日：2018-04-19
Applicant: Biological E Limited
Inventor： Balamurali Masilamani , Rajan Sriraman , Mandar Shirish Dixit , Deviprasanna Chakka , Satyam Naidu Sureddi , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla
IPC: C12N1/20 , A61K39/05 , A61K39/385 , C12P21/00 , C07K14/34
Abstract: The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.
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Patent Agency Ranking
公开(公告)号：US20210009641A1
公开(公告)日：2021-01-14
申请号：US16976794
申请日：2019-03-01
Applicant: Biological E Limited
Inventor： Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Swetha Kamireddy
IPC: C07K14/315 , C12N15/77 , A61K39/09
Abstract: The present invention relates to expression of Pneumococcal Surface Protein A (PspA). The invention represents an advancement in the field of genetic engineering and vaccine technology. The invention discloses expression vectors and recombinant host cells for expression of truncated PspA peptide. The invention also discloses vaccine compositions comprising the truncated peptides as carrier protein.
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公开(公告)号：US12048739B2
公开(公告)日：2024-07-30
申请号：US17278181
申请日：2019-09-23
Applicant: Biological E Limited
Inventor： Rajendar Burki , Vivek Babu Kandimalla , Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Veerapandu Sangareddy
CPC classification number: A61K39/092 , A61K31/715 , A61K47/62 , C08B37/0003 , A61K2039/6037 , A61K2039/70
Abstract: The invention relates to capsular polysaccharides of Streptococcus pneumoniae. More specifically, the present invention relates to sized and purified capsular polysaccharides of Streptococcus pneumoniae serotypes 2, 15A, 15C & 35B and process for their preparation.
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公开(公告)号：US20230322871A1
公开(公告)日：2023-10-12
申请号：US18338584
申请日：2023-06-21
Applicant: Biological E Limited
Inventor： Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Swetha Kamireddy
IPC: C07K14/315 , A61K39/09 , C12N15/77 , A61K47/64 , A61K39/116
CPC classification number: C07K14/3156 , A61K39/092 , C12N15/77 , A61K47/646 , A61K39/116 , A61K2039/6068
Abstract: The present invention relates to expression of Pneumococcal Surface Protein A (PspA). The invention represents an advancement in the field of genetic engineering and vaccine technology. The invention discloses expression vectors and recombinant host cells for expression of truncated PspA peptide. The invention also discloses vaccine compositions comprising the truncated peptides as carrier protein.
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公开(公告)号：US20210346488A1
公开(公告)日：2021-11-11
申请号：US17278181
申请日：2019-09-23
Applicant: Biological E Limited
Inventor： Rajendar Burki , Vivek Babu Kandimalla , Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Veerapandu Sangareddy
IPC: A61K39/09 , A61K47/62 , A61K31/715 , C08B37/00
Abstract: The invention relates to capsular polysaccharides of Streptococcus pneumoniae. More specifically, the present invention relates to sized and purified capsular polysaccharides of Streptococcus pneumoniae serotypes 2, 15A, 15C & 35B and process for their preparation.
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公开(公告)号：US20240325516A1
公开(公告)日：2024-10-03
申请号：US18741232
申请日：2024-06-12
Applicant: Biological E Limited
Inventor： Rajendar Burki , Vivek Babu Kandimalla , Rajan Sriraman , Ramesh Venkat Matur , Narender Dev Mantena , Mahima Datla , Veerapandu Sangareddy
IPC: A61K39/09 , A61K31/715 , A61K39/00 , A61K47/62 , C08B37/00
CPC classification number: A61K39/092 , A61K31/715 , A61K47/62 , C08B37/0003 , A61K2039/6037 , A61K2039/70
Abstract: The invention relates to capsular polysaccharides of Streptococcus pneumoniae. More specifically, the present invention relates to sized and purified capsular polysaccharides of Streptococcus pneumoniae serotypes 2, 15A, 15C & 35B and process for their preparation.
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