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公开(公告)号：US10889547B2
公开(公告)日：2021-01-12
申请号：US16311206
申请日：2017-06-22
申请人： BASF SE
IPC分类号： C07D215/20 , B01D3/14 , A23K20/132 , A23L3/3526 , B01D3/10 , B01J19/30
摘要： The present invention relates to a process for purifying ethoxyquin by distillation, to high-purity ethoxyquin obtainable by means of distillative purification and to the use thereof, particularly as additive in foodstuffs and feedstuffs.
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公开(公告)号：US09975837B2
公开(公告)日：2018-05-22
申请号：US15536524
申请日：2015-12-18
申请人： BASF SE
发明人： Mathias Schelwies , Rocco Paciello , Gunnar Heydrich , Günter Wegner , Gerd-Dieter Tebben , Martin Haubner , Andreas Keller , Oliver Bey , Stephanie Renz , Georg Seeber
CPC分类号： C07C45/62 , C07B2200/07 , C07C29/172 , C07C29/56 , C07C2601/14 , C07C47/21 , C07C47/02 , C07C35/12 , C07C35/17
摘要： The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.
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公开(公告)号：US10294182B2
公开(公告)日：2019-05-21
申请号：US15127135
申请日：2015-03-13
申请人： BASF SE
发明人： Matthias Rauls , Stefan Ziegler , Martin Haubner
摘要： The present invention relates to a method for separating off a substance from a solution, in which electromagnetic radiation is radiated into the solution, an intensity of the electromagnetic radiation which has been scattered by crystals located in the solution is detected, the detected intensity is compared with a desired intensity (IS) and the temperature of the solution is regulated depending on the difference between the detected intensity and the desired intensity (IS) in such a way that the amount of this difference is reduced. If the amount of the difference between the detected intensity and the desired intensity (IS) is less than a limiting value, a crystallization method is started in which crystals of the substance are obtained which are then separated off.
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4.发明授权公开(公告)号：US11884611B2
公开(公告)日：2024-01-30
申请号：US17274135
申请日：2019-09-03
申请人： BASF SE
发明人： Oliver Bey , Peter Zehner , Michael Acker , Rocco Paciello , Mathias Schelwies , Martin Haubner , Guenter Wegner , Gerd Tebben , Gunnar Heydrich , Georg Seeber
IPC分类号： C07C29/141 , B01J10/00 , B01J3/04 , B01J19/00 , B01J19/24 , B01J19/26 , B01J19/30 , B01J19/32 , B01J31/20
CPC分类号： C07C29/141 , B01J3/042 , B01J10/00 , B01J10/002 , B01J19/0066 , B01J19/244 , B01J19/2465 , B01J19/26 , B01J19/30 , B01J19/32 , B01J31/20 , B01J2219/0009 , B01J2219/0025 , B01J2219/00092 , B01J2219/00096 , B01J2219/185 , B01J2219/1943 , B01J2531/822 , C07B2200/07
摘要： A reactor for performing a gas/liquid biphasic high-pressure reaction with a foaming medium, comprising an interior formed by a cylindrical, vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by internals into a backmixed zone and a zone of limited backmixing, wherein the backmixed zone and the zone of limited backmixing are consecutively traversable by the reaction mixture, wherein the backmixed zone comprises means for introducing gas and liquid and a gas outlet and also comprises at least one mixing apparatus selected from a stirrer, a jet nozzle and means for injecting the gas, and the zone of limited backmixing comprises a reaction product outlet, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a riser tube whose lower end is arranged within the backmixed zone and whose upper end opens into the zone of limited backmixing so that liquid from the backmixed zone can ascend into the zone of limited backmixing via the riser tube, wherein flow into the zone of limited backmixing enters from below. The reactor is configured such that the high-pressure reaction space is optimally utilized and contamination of workup steps or subsequent reactions arranged downstream of the high-pressure reaction with foam is substantially avoided. The invention further relates to a process for performing a continuous gas/liquid biphasic high-pressure reaction in the reactor.
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5.发明授权公开(公告)号：US11529607B2
公开(公告)日：2022-12-20
申请号：US17274148
申请日：2019-09-03
申请人： BASF SE
发明人： Oliver Bey , Peter Zehner , Mathias Schelwies , Rocco Paciello , Martin Haubner , Guenter Wegner , Gerd Tebben , Gunnar Heydrich , Georg Seeber , Michael Acker
摘要： A reactor for performing a reaction between two immiscible fluids of different density, comprising an interior formed by a cylindrical, vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by internals into a backmixed zone, a zone of limited backmixing preferably arranged below the backmixed zone and a plug-flow zone which are at least consecutively traversable by one of the fluids, wherein the backmixed zone comprises at least one inlet and the plug-flow zone comprises an outlet and the backmixed zone comprises at least one mixing apparatus selected from a stirrer, a jet nozzle and means for injecting the fluid of lower density, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor, which delimits the zone of limited backmixing from the plug-flow zone and which comprises a first passage to the backmixed zone and a second passage to the plug-flow zone, a second internal element which delimits the backmixed zone from the plug-flow zone such that there is no direct fluid connection between the backmixed zone and the plug-flow zone, and backmixing-preventing third internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing. The reactor allows an optimal residence time distribution in the reaction of the two immiscible fluids of different density. The invention further relates to a process for performing a continuous reaction in the reactor.
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公开(公告)号：US11766653B2
公开(公告)日：2023-09-26
申请号：US17274110
申请日：2019-09-03
申请人： BASF SE
发明人： Oliver Bey , Peter Zehner , Andreas Keller , Stephanie Renz , Mathias Schelwies , Rocco Paciello , Martin Haubner , Guenter Wegner , Gerd Tebben , Gunnar Heydrich , Georg Seeber
CPC分类号： B01J10/002 , B01J3/02 , B01J3/042 , B01J4/002 , B01J31/2409 , C07C45/62 , B01J2203/065 , B01J2531/822 , C07B53/00
摘要： A process for performing a continuous gas/liquid biphasic high-pressure reaction, wherein a gas and a liquid are introduced into a backmixed zone of a reactor and in the backmixed zone the gas is dispersed in the liquid by stirring, injection of gas and/or a liquid jet, a reaction mixture consecutively traverses the backmixed zone and a zone of limited backmixing, and a liquid reaction product is withdrawn at a reaction product outlet of the zone of limited backmixing, wherein the reactor comprises: an interior formed by a cylindrical vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by means of internals into the backmixed zone, the zone of limited backmixing and a cavity, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a third internal element which in the interior extends in the longitudinal direction of the reactor and is open at the bottom, wherein the third internal element forms the cavity in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume. The reaction volume of the reactor used in the process can be reversibly reduced in simple fashion. The invention further relates to a process for adapting the reaction volume of a reactor suitable for performing a gas/liquid biphasic high-pressure reaction having an outlet for a liquid reaction product in which an internal element is arranged so as to form a cavity open at the bottom in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume.
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公开(公告)号：USRE49036E1
公开(公告)日：2022-04-19
申请号：US16521935
申请日：2019-07-25
申请人： BASF SE
发明人： Mathias Schelwies , Rocco Paciello , Gunnar Heydrich , Günter Wegner , Gerd-Dieter Tebben , Martin Haubner , Andreas Keller , Oliver Bey , Stephanie Renz , Georg Seeber
摘要： The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.
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公开(公告)号：US10301244B2
公开(公告)日：2019-05-28
申请号：US15964400
申请日：2018-04-27
申请人： BASF SE
发明人： Mathias Schelwies , Rocco Paciello , Gunnar Heydrich , Günter Wegner , Gerd-Dieter Tebben , Martin Haubner , Andreas Keller , Oliver Bey , Stephanie Renz , Georg Seeber
摘要： The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R1, R2: are identical or different and are C6- to C10-aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino; Z is a group CHR3R4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C1- to C6-alkyl, C3- to C6-cycloalkyl, C6- to C10-aryl, C1- to C6-alkoxy and amino, wherein R3 and R4 are as defined in the claims and the description.
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