公开(公告)号：US20210251905A1

公开(公告)日：2021-08-19

申请号：US17052934

申请日：2019-05-15

Applicant: BASF SE

Inventor： Theo SMIT ,  Matthias KARL ,  Felicitas GUTH ,  Maximilian ANGEL ,  Karl KOLTER ,  Frank SCHMIDT ,  Maximilian BLOCHBERGER-CLAUS

IPC: A61K9/20

Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.

公开(公告)号：US20210387156A1

公开(公告)日：2021-12-16

申请号：US17290669

申请日：2019-10-29

Applicant: BASF SE

Inventor： Bernd Dieter OSCHMANN ,  Kerstin MUELHEIMS ,  Wolfgang KRAUSE ,  Patrick LEIBACH ,  Roland Hinrich STAFF ,  Dieter FLICK ,  Lukas MAYR ,  Stephanie RENZ ,  Felicitas GUTH ,  Klaus KAHLE ,  Stephan HUEFFER ,  Tobias Maximilian MERKEL ,  Axel BINDER ,  Karl KOLTER ,  Yean Yik GEOERG ,  Regina VOGELSANG ,  Antoine Maxime Charles Jos BEZIAU

IPC: B01J13/20 ,  B01J13/22

Abstract: The present invention relates to processes for producing microparticles having, in their interior, at least one cavity which is connected via pores to the surface of the microparticles and which have been laden with at least one organic active of low molecular weight. The invention especially relates to a process for loading microparticles with at least one organic active of low molecular weight, wherein the active has been embedded in a matrix and/or the pores of the microparticles have been closed by means of a substance applied to the surface of the microparticles. The invention additionally relates to a process for sealing microparticles laden with at least one organic active of low molecular weight. The invention also relates to compositions of microparticles laden with at least one active of low molecular weight and to the use thereof.

公开(公告)号：US20190240119A1

公开(公告)日：2019-08-08

申请号：US16316802

申请日：2017-07-17

Applicant: BASF SE

Inventor： KATHRIN MEYER-BOEHM ,  Thrandur HELGASON ,  Raajvinder SINGH ,  Walter DOBLER ,  Peter SCHORDING ,  Christof Wilhelm WIGBERS ,  Karl KOLTER ,  Stefan BRUHNS ,  Wolf PELLETIER ,  Daniel WAGNER

IPC: A61K8/02 ,  A23L33/155 ,  A23K20/174 ,  A23P10/20 ,  A61K8/37 ,  A61K8/35 ,  A61K8/67 ,  A61K8/34 ,  A61K31/12 ,  A61K31/122 ,  A61K31/355 ,  A61K31/05 ,  A61K31/375 ,  A61K9/14

CPC classification number: A61K8/022 ,  A23K20/174 ,  A23L33/15 ,  A23L33/155 ,  A23P10/20 ,  A23V2002/00 ,  A61K8/31 ,  A61K8/347 ,  A61K8/35 ,  A61K8/37 ,  A61K8/67 ,  A61K8/676 ,  A61K8/678 ,  A61K9/14 ,  A61K31/015 ,  A61K31/05 ,  A61K31/12 ,  A61K31/122 ,  A61K31/235 ,  A61K31/355 ,  A61K31/375 ,  A61K45/06 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/52 ,  A61K2800/522 ,  A61Q19/00 ,  A23V2250/211 ,  A23V2250/712 ,  A61K2300/00

Abstract: The present invention relates to a pulverulent vitamin formulation in which the vitamin essentially has a particle size of less than 0.7 μm and which comprises an effective amount of propyl gallate, and also to processes for producing this formulation, and to formulations obtainable by these processes and to the use thereof as animal feed, food, food supplement, personal care product or pharmaceutical composition. The formulations of the invention have improved stability compared to the prior art.

公开(公告)号：US20210153540A1

公开(公告)日：2021-05-27

申请号：US17256385

申请日：2019-05-29

Applicant: BASF SE

Inventor： Kathrin MEYER-BOEHM ,  Andreas HABICH ,  Daniel WAGNER ,  Wolf PELLETIER ,  Walter DOBLER ,  Peter SCHORDING ,  Karl KOLTER

IPC: A23P10/47 ,  A23L33/10 ,  A61K8/02 ,  A61K8/25 ,  A61K9/16

Abstract: The present invention relates to dust-free preparations dispersible in cold water. These preparations consist of particles comprising water-insoluble or only sparingly water-soluble active substance(s), said particles being coated with one or more layers, the outermost layer comprising as principal component one or more hydrophobic powdering agents on which at least one dispersant is absorbed. The invention also relates to a process for producing these particles and to the use thereof in food supplements, foodstuffs, animal feeds, personal-care products, and medicaments.

公开(公告)号：US20190231659A1

公开(公告)日：2019-08-01

申请号：US16339404

申请日：2017-10-04

Applicant: BASF SE

Inventor： Ewelina BURAKOWSKA-MEISE ,  Wolfgang KRAUSE ,  Patrick LEIBACH ,  Karl KOLTER

IPC: A61K8/11 ,  A61K8/85 ,  A61K8/06 ,  A61K8/81 ,  A61K8/87

CPC classification number: A61K8/11 ,  A61K8/068 ,  A61K8/8111 ,  A61K8/8152 ,  A61K8/85 ,  A61K8/87 ,  A61K9/007 ,  A61K9/5031 ,  A61K9/5089 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q19/10 ,  B01J13/02 ,  B01J13/06 ,  B01J13/206 ,  C11D3/505

Abstract: The present invention relates to compositions of spherical microparticles composed of a wall material and at least one cavity that comprises a gas and/or a liquid, which have pores on the surface thereof, wherein the spherical microparticles have a mean particle diameter of 10-600 μm and wherein at least 80% of those microparticles, the particle diameter of which does not deviate from the mean particle diameter of the microparticles of the composition by more than 20%, each have on average at least 10 pores, the diameter of which is in the range from 1/5000 to ⅕ of the mean particle diameter, and, furthermore, the diameter of each of these pores is at least 20 nm,wherein the wall material consists of a composition comprising at least one aliphatic-aromatic polyester, and the wall material has a solubility at 25° C. of at least 50 g/l in dichloromethane, a method for the preparation thereof and also the use thereof.

公开(公告)号：US20190090529A1

公开(公告)日：2019-03-28

申请号：US16081538

申请日：2017-02-28

Applicant: BASF SE

Inventor： Kathrin MEYER-BOEHM ,  Thrandur HELGASON ,  Karl KOLTER ,  Walter DOBLER ,  Christol STADAGER ,  MIchael SCHOENHERR ,  Katja KESTEN ,  Nikolaus NESTLE

IPC: A23P10/30 ,  A23L33/15 ,  A23L33/12 ,  A23L33/105 ,  A61K31/201 ,  A23L33/125 ,  A61K9/107 ,  A61K9/16 ,  A23L33/16

Abstract: The present invention relates to a method for producing particles containing carotenoid and/or vitamin and/or omega-3 fatty acids and/or phytosterols and/or conjugated linoleic acids, having a narrow particle size distribution and uniform spherical shape and density, and also to particles obtainable by this method and use thereof as food supplements, foodstuffs, feedstuffs, body care products and medicaments. The particles according to the invention exhibit improved storage stability compared to the prior art.