知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

10 records (took 0.028 seconds)

    PROCESS FOR PRODUCING 2'-O-FUCOSYLLACTOSE
    4.
    发明申请
    PROCESS FOR PRODUCING 2'-O-FUCOSYLLACTOSE 有权

    公开(公告)号：US20210130384A1

    公开(公告)日：2021-05-06

    申请号：US16074168

    申请日：2017-02-02

    Applicant: BASF SE

    Inventor： MICHAEL PUHL ,  Wolfgfang SIEGEL ,  Stephanie RENZ ,  Andreas WÖLFERT

    IPC: C07H1/06 ,  C07H15/18 ,  C07H3/06

    Abstract: The present invention relates to a method for preparing 2′-O-fucosyllactose, the intermediates obtainable by this method and the use of these intermediates. The preparation comprises the reaction of a protected fucose of the general formula (I) with a tri(C1-C6-alkyl)silyl iodide to give a protected 1-iodofucose followed by the reaction of the protected 1-iodofucose with a compound of the general formula (II), in the presence of at least one base and deprotecting the resulting coupling product to afford 2′-O-fucosyllactose. In this context, the variables are each defined as follows: Ra and Rb are the same or different and are —C(═O)—C1-C6-alkyl, or —C(═O)-phenyl, wherein said phenyl is unsubstituted or optionally has 1 to 5 substituents, or Ra and Rb together are a radical —(C═O)— or a substituted methylene radical —C(RdRe)—, Rc is a radical RSi or is benzyl, wherein said benzyl is unsubstituted or optionally has 1, 2 or 3 substituents, RSi is a radical of the formula SiRfRgRh, where Rf, Rg and Rh are the same or different and are C1-C8-alkyl for example, R1 is a radical —C(═O)—R11 or a radical SiR12R13R14 R2 are the same or different and are C1-C8-alkyl for example; R3 are the same or different and are for example C1-C8-alkyl or both radicals R3 together form a linear C1-C4-alkenyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

    METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE
    5.
    发明申请
    METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE 审中-公开

    公开(公告)号：US20190100547A1

    公开(公告)日：2019-04-04

    申请号：US16082581

    申请日：2017-03-08

    Applicant: BASF SE

    Inventor： MICHAEL PUHL ,  Stephanie RENZ ,  Andreas WOELFERT

    IPC: C07H3/08 ,  C07H1/00

    Abstract: The present invention relates to a method for preparing 2′-O-fucosyllactose and to the protected fucosyl donor of the formula (I) used in this method. The method comprises reacting the fucose derivative of the formula (I) below with the compound of the general formula (II), in the presence of an activating reagent. In the formulae (I) and (II), the variables are each defined as follows: X is Br or a S-bound radical, namely —SCN, —S(O)n—RX1or —S—RX2, wherein RX1 preferably is an optionally substituted phenyl, and RX2 preferably is C1-C4-alkyl, 2-oxazolin-2-yl, 2-thiazolin-2-yl, benzoxazol-2-yl, benzothiazol-2-yl or pyridin-2-yl; RSi are the same or different and are radicals of the formula SiRaRbRc, wherein Ra, Rb and Rc preferably are each methyl; R1 is a C(=O)—R11 radical or an SiR12R13R14 radical, wherein R11 is preferably methyl, phenyl or tert-butyl, and R12, R13 and R14 preferably are each methyl; R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

    METHOD FOR CARRYING OUT A GAS/FLUID TWO-PHASE HIGH-PRESSURE REACTION
    8.
    发明申请
    METHOD FOR CARRYING OUT A GAS/FLUID TWO-PHASE HIGH-PRESSURE REACTION 有权

    公开(公告)号：US20210354101A1

    公开(公告)日：2021-11-18

    申请号：US17274110

    申请日：2019-09-03

    Applicant: BASF SE

    Inventor： Oliver BEY ,  Peter ZEHNER ,  Andreas KELLER ,  Stephanie RENZ ,  Mathias SCHELWIES ,  Rocco PACIELLO ,  Martin HAUBNER ,  Guenter WEGNER ,  Gerd TEBBEN ,  Gunnar HEYDRICH ,  Georg SEEBER

    IPC: B01J10/00 ,  B01J3/04 ,  B01J3/02 ,  B01J4/00 ,  C07C45/62 ,  B01J31/24

    Abstract: A process for performing a continuous gas/liquid biphasic high-pressure reaction, wherein a gas and a liquid are introduced into a backmixed zone of a reactor and in the backmixed zone the gas is dispersed in the liquid by stirring, injection of gas and/or a liquid jet, a reaction mixture consecutively traverses the backmixed zone and a zone of limited backmixing, and a liquid reaction product is withdrawn at a reaction product outlet of the zone of limited backmixing, wherein the reactor comprises: an interior formed by a cylindrical vertically oriented elongate shell, a bottom and a cap, wherein the interior is divided by means of internals into the backmixed zone, the zone of limited backmixing and a cavity, a first cylindrical internal element which in the interior extends in the longitudinal direction of the reactor and which delimits the zone of limited backmixing from the backmixed zone, backmixing-preventing second internal elements in the form of random packings, structured packings or liquid-permeable trays arranged in the zone of limited backmixing and a third internal element which in the interior extends in the longitudinal direction of the reactor and is open at the bottom, wherein the third internal element forms the cavity in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume. The reaction volume of the reactor used in the process can be reversibly reduced in simple fashion. The invention further relates to a process for adapting the reaction volume of a reactor suitable for performing a gas/liquid biphasic high-pressure reaction having an outlet for a liquid reaction product in which an internal element is arranged so as to form a cavity open at the bottom in which gas bubbles collect and do not escape upwards, thus preventing the volume of the cavity from being occupied by liquid and reducing the reaction volume.

Patent Agency Ranking