公开(公告)号：US20240293790A1

公开(公告)日：2024-09-05

申请号：US18019795

申请日：2020-08-06

Applicant: Symrise AG

Inventor： Julian Alexander Georgi ,  Britta Raabe ,  Benjamin Rost ,  Andreas Vogel ,  Ralf Bertram ,  Daniela Gregor ,  Christina Koepke ,  Stefanie Bargsten ,  Patrick Ott

IPC: B01J13/16 ,  A01N25/28 ,  A01P7/04 ,  A01P17/00 ,  A61K8/04 ,  A61K8/84 ,  A61K8/87 ,  A61K9/50 ,  A61Q13/00 ,  A61Q19/00 ,  B01J13/20 ,  C11D3/00 ,  C11D3/37 ,  C11D3/50 ,  C11D17/00

CPC classification number: B01J13/16 ,  A01N25/28 ,  A01P7/04 ,  A01P17/00 ,  A61K8/04 ,  A61K8/84 ,  A61K8/87 ,  A61K9/5031 ,  A61Q13/00 ,  A61Q19/00 ,  B01J13/206 ,  C11D3/001 ,  C11D3/3726 ,  C11D3/505 ,  C11D17/0039

Abstract: The present invention relates to a process for the preparation of biodegradable polyurea/polyurethane microcapsules, preferably perfume-containing polyurea/polyurethane microcapsules, which have a balance of biodegradability, stability and performance compared to prior art microcapsules. In addition, the present invention relates to biodegradable polyurea/polyurethane microcapsules comprising at least one lipophilic active ingredient obtainable by the process of the invention. In another aspect, the invention described herein relates to the use of such microcapsules or microcapsule dispersions comprising the microcapsules according to the invention for the manufacture of household products, textile care products, detergents, fabric softeners, cleaning agents, scent boosters, scent lotion or scent enhancers, cosmetics, personal care products, agricultural products or pharmaceutical products. Ultimately, the present invention relates to consumer products comprising such microcapsules or microcapsule dispersions.

公开(公告)号：US20240085287A1

公开(公告)日：2024-03-14

申请号：US18514235

申请日：2023-11-20

Applicant: Vilnius University ,  Droplet Genomics

Inventor： Linas Mazutis ,  Greta Stonyte ,  Karolis Leonavicius ,  Ausra Zelvyte

IPC: G01N1/40 ,  B01J13/04 ,  B01J13/20 ,  C12Q1/6806

CPC classification number: G01N1/4077 ,  B01J13/046 ,  B01J13/206 ,  C12Q1/6806

Abstract: This invention relates to methods and systems for isolation of species in semi-permeable capsules and processing of encapsulated species through series of steps and/or reactions. To produce capsules, first aqueous two-phase system (ATPS) droplets are generated using microfluidics system. Then the hydrogel shell layer is hardened by inducing polymerization. As exemplified in this invention to achieve concentric ATPS droplet formation density-matched PEGDA and Dextran polymer solutions can be used. Once a capsule is formed, its composition can be changed by adding new reagents or replacing out old ones (e.g. by resuspending capsules in desired aqueous solution). The hydrogel shell of semi-permeable capsules can be dissolved at selected step during multi-step procedures to release the encapsulated species. This invention exemplifies isolation of individual cells within capsules and using the encapsulated cells for genotypic and phenotypic analysis. This invention also exemplifies use of capsules in multi-step procedures to perform complex biological reactions.

公开(公告)号：US20240050914A1

公开(公告)日：2024-02-15

申请号：US18278033

申请日：2022-02-21

Applicant: Microcaps AG

Inventor： Kaj Pletscher

IPC: B01J13/04 ,  B01J13/20

CPC classification number: B01J13/043 ,  B01J13/206

Abstract: A method for generating capsules includes: a. providing in a first chamber a dispersed phase, the dispersed phase including a solution including a first solvent and a matrix-forming agent, the matrix-forming agent is a solid in its pure state and the first solvent and the matrix-forming agent are configured such that the matrix-forming agent is soluble in the first solvent; and b. providing in a second chamber a continuous phase, the continuous phase including a second solvent. The first and second chambers are fluidic connected by channel(s). The method further includes: c. guiding the dispersed phase from the first chamber through the channel(s) into the second chamber to form an emulsion or a dispersion including a plurality of droplets of the dispersed phase, in the continuous phase; and d. removing the first solvent from the droplets of the dispersed phase and solidifying the matrix-forming agent to form a capsule.

公开(公告)号：US09926551B2

公开(公告)日：2018-03-27

申请号：US14902072

申请日：2014-06-27

Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.

Inventor： Heiko Zimmermann ,  Julia Neubauer

IPC: C12N11/04 ,  C12M1/12 ,  C12N11/10 ,  B01J13/14 ,  B01J13/20 ,  A61K35/12

CPC classification number: C12N11/04 ,  A61K2035/128 ,  B01J13/14 ,  B01J13/206 ,  C12M25/01 ,  C12N11/10

Abstract: The invention relates to an encapsulating device (100), which is designed to encapsulate a sample (1, 2) in a polymer capsule, comprising a drop generator (10), which is designed to provide a drop (3) of a suspension, which drop contains the sample (1), and a cross-linking device (20), which is designed to polymerize the drop (3), wherein the drop generator (10) has a retaining device (11), which is designed to accommodate the drop (3) in a hanging state, and the cross-linking device (20) is designed to feed a polymerization substance to the hanging drop (3) on the retaining device (11) and to form the polymer capsule. The invention further relates to a method for encapsulating a sample (1, 2) in a polymer capsule.

公开(公告)号：US09895672B2

公开(公告)日：2018-02-20

申请号：US12874618

申请日：2010-09-02

Applicant: Olav Gaserod ,  Christian Klein Larsen ,  Peder Oscar Andersen

Inventor： Olav Gaserod ,  Christian Klein Larsen ,  Peder Oscar Andersen

IPC: A61K9/48 ,  A23L1/0532 ,  A23P1/04 ,  B01J13/04 ,  A61K47/02 ,  A61K47/36 ,  B01J13/20 ,  A23K40/30 ,  A23P10/30

CPC classification number: B01J13/046 ,  A23K40/30 ,  A23P10/30 ,  A61K9/4808 ,  A61K9/4816 ,  A61K9/4833 ,  A61K47/02 ,  A61K47/36 ,  B01J13/20 ,  B01J13/206

Abstract: The invention is directed to a seamless alginate capsule having a film encapsulating a fill material, in which the film comprises alginate, noncrystallizing plasticizer, and glycerol and in which a ratio by weight of noncrystallizing plasticizer to glycerol in the film is between about 1:1 and about 8:1. The invention is also directed to a method of making the seamless alginate capsules and to capsules made by the method. The capsules have excellent breaking strength and are resistant to oxidation of the fill material.

公开(公告)号：US09788563B2

公开(公告)日：2017-10-17

申请号：US13088165

申请日：2011-04-15

Applicant: Yuan Fang ,  Breda Kennedy ,  Teodoro Rivera ,  Kyoung-Sik Han ,  Anil Kumar Anal ,  Harjinder Singh

Inventor： Yuan Fang ,  Breda Kennedy ,  Teodoro Rivera ,  Kyoung-Sik Han ,  Anil Kumar Anal ,  Harjinder Singh

IPC: A23L1/00 ,  A23L2/52 ,  A23L2/02 ,  A23L2/60 ,  A23L2/66 ,  A23L2/68 ,  A61K35/745 ,  A61K35/747 ,  C12N1/04 ,  C12N11/04 ,  C12N11/10 ,  B01J13/04 ,  B01J13/20 ,  A23P10/30 ,  A23L29/256 ,  A23L27/30 ,  A23L33/135 ,  A23L33/155 ,  A23L33/16 ,  A23L33/19

CPC classification number: A23L2/52 ,  A23L2/02 ,  A23L2/60 ,  A23L2/66 ,  A23L2/68 ,  A23L27/30 ,  A23L29/256 ,  A23L33/135 ,  A23L33/155 ,  A23L33/16 ,  A23L33/19 ,  A23P10/30 ,  A23V2002/00 ,  A23Y2220/03 ,  A23Y2300/00 ,  A61K35/745 ,  A61K35/747 ,  B01J13/046 ,  B01J13/206 ,  C12N1/04 ,  C12N11/04 ,  C12N11/10 ,  A23V2200/224 ,  A23V2200/3204 ,  A23V2250/5024 ,  A23V2250/54252 ,  A23V2250/5026

Abstract: Comestible products, for example beverage products, are disclosed containing encapsulated probiotic bacteria having resistance to subjection to at least thermal and acidic conditions. Beverage products include at least one aqueous liquid and capsules comprising a gelled mixture of alginate and denatured protein, and probiotic bacteria entrapped within the gelled mixture. The average particle size of the capsules is optionally less than 1000 microns (μm) in diameter, such as less than 500 μm in diameter. Methods are provided for making such encapsulated probiotics by providing a mixture comprising sodium alginate, denatured protein and active probiotic cells, and combining the mixture with a divalent cation to initiate cold gelation of the sodium alginate and denatured protein to form a second mixture. The second mixture is passed through an opening having a diameter of less than 1000 μm to form capsules. The weight ratio of protein to alginate is from 1:1 to 9:1.

公开(公告)号：US09687424B2

公开(公告)日：2017-06-27

申请号：US13969038

申请日：2013-08-16

Applicant: International Flavors & Fragrances Inc.

Inventor： Yabin Lei ,  Li Xu ,  Carol Joyce ,  Lewis Michael Popplewell

IPC: A61K8/11 ,  A61Q5/02 ,  A61Q5/12 ,  A61K8/73 ,  A61K8/84 ,  A61Q19/10 ,  B01J13/14 ,  B01J13/16 ,  C11D3/50 ,  C11D17/00 ,  B01J13/20 ,  A61Q5/00

CPC classification number: A61K8/11 ,  A61K8/731 ,  A61K8/84 ,  A61K2800/412 ,  A61K2800/624 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10 ,  B01J13/14 ,  B01J13/16 ,  B01J13/206 ,  C11D3/505 ,  C11D17/0039

Abstract: Polyurea capsules that encapsulate active materials in polymeric walls resulting from the polymerization of an aliphatic polyisocyanate and a cross-linking agent such as a diamine, amphoteric amine or guanidine amine/salt are provided as are consumer products containing said polyurea capsules and for methods for producing such capsules.

公开(公告)号：US09458423B2

公开(公告)日：2016-10-04

申请号：US14603882

申请日：2015-01-23

Applicant: MORISHITA JINTAN CO., LTD. ,  Yasuhiro Konishi

Inventor： Yasuhiro Konishi ,  Koshiro Tamaoki ,  Ryosei Kamaguchi ,  Daisuke Tagawa ,  Taku Hashimoto ,  Masaaki Nakatsuji

IPC: C22B3/18 ,  C12N1/20 ,  B01J13/14 ,  B01J13/20 ,  C22B7/00 ,  C22B3/24 ,  B29C35/08 ,  B29C47/06 ,  A61K35/12 ,  B29K101/12

CPC classification number: C12N1/20 ,  A61K2035/128 ,  B01J13/14 ,  B01J13/206 ,  B29C35/0805 ,  B29C47/065 ,  B29C2035/0827 ,  B29K2101/12 ,  C22B3/18 ,  C22B3/24 ,  C22B7/006 ,  Y02P10/234 ,  Y02P10/238

Abstract: Provided are: a capsule for non-ferrous metal collection that can collect a non-ferrous metal; and a method for collecting a non-ferrous metal using same. The capsule for non-ferrous metal collection comprises capsule contents and a covering section covering the capsule contents, and collects a non-ferrous metal within the capsule for non-ferrous metal collection by means of the capsule for non-ferrous metal collection being immersed in a solution containing a non-ferrous metal.

Abstract translation: 提供：可收集有色金属的有色金属收集胶囊; 以及使用其收集有色金属的方法。 用于有色金属收集的胶囊包括胶囊内容物和覆盖胶囊内容物的覆盖部分，并通过用于有色金属收集的胶囊收集用于有色金属收集的有色金属收集的有色金属 含有有色金属的溶液。

公开(公告)号：US20160128942A1

公开(公告)日：2016-05-12

申请号：US14974201

申请日：2015-12-18

Applicant: AntriaBio, Inc.

Inventor： Greg Bryden Sebring

IPC: A61K9/16 ,  B01D11/04 ,  A61K38/26 ,  A61K47/48 ,  A61K38/28

CPC classification number: A61K9/1682 ,  A61K9/16 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/26 ,  A61K38/28 ,  A61K47/60 ,  B01D11/0415 ,  B01D11/0492 ,  B01J13/206

Abstract: Embodiments may include a method for reducing a solvent concentration in a plurality of microparticles. The method may involve contacting a mixture including the plurality of microparticles and the solvent with water to form an aqueous suspension. A first portion of the solvent may dissolve into the water of the aqueous suspension to reduce the solvent concentration in the plurality of microparticles from a first solvent concentration in the mixture to a second solvent concentration in the aqueous suspension. The method may also include transferring the aqueous suspension to a concentration unit that may further reduce the solvent concentration from the second solvent concentration to a third solvent concentration. The method may further include transferring a microparticle concentrate with the third solvent concentration to a washing unit to form an amalgam of washed microparticles with a fourth solvent concentration. The method may also include drying the amalgam of washed microparticles.

公开(公告)号：US20150336066A1

公开(公告)日：2015-11-26

申请号：US14819822

申请日：2015-08-06

Applicant: Lu-Kwang Ju ,  Uchechukwu Anozie

Inventor： Lu-Kwang Ju ,  Uchechukwu Anozie

IPC: B01J13/18 ,  B01J13/20

CPC classification number: B01J13/18 ,  B01J13/20 ,  B01J13/206 ,  C05D9/02 ,  C05G3/0017 ,  C05G3/0047 ,  Y10T428/2989

Abstract: A method for encapsulating a material, the steps include choosing a material to encapsulate; placing the material into a material solvent to form a material solution; forming a primary emulsion of the material solution in an immiscible liquid medium that is immiscible with the material solvent, wherein the material solution is the disperse phase and the immiscible liquid medium is the continuous phase of the primary emulsion, wherein the immiscible liquid medium contains an encapsulating agent dissolved therein, the encapsulating agent capable of being crosslinked, polymerized, gelled, hardened or solidified; adding the primary emulsion as droplets into a crosslinking medium, wherein the crosslinking medium is immiscible with the continuous phase immiscible liquid medium of the primary emulsion, and thereafter activating the crosslinking, polymerizing, gelling, hardening or solidifying of the encapsulating agent to envelope the material in a crosslinked, polymerized, gelled, hardened or solidified matrix forming the droplets into beads.

Abstract translation: 一种封装材料的方法，所述步骤包括选择要封装的材料; 将材料放入材料溶剂中以形成材料溶液; 在与所述材料溶剂不混溶的不混溶液体介质中形成所述材料溶液的主乳液，其中所述材料溶液是分散相，并且所述不混溶液体介质是所述主乳液的连续相，其中所述不混溶液体介质包含 溶解在其中的包封剂，能够交联，聚合，凝胶化，硬化或固化的包封剂; 将初级乳液作为液滴加入交联介质中，其中交联介质与初级乳液的连续相不混溶液体介质不混溶，然后活化封装剂的交联，聚合，凝胶化，固化或固化以包封材料 在交联的，聚合的，胶凝的，硬化的或固化的基质中形成液滴成珠。