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    Coating compositions for bitterness inhibition
    1.
    发明授权
    Coating compositions for bitterness inhibition 有权
    用于苦味抑制的涂料组合物

    公开(公告)号：US07294347B2

    公开(公告)日：2007-11-13

    申请号：US10871534

    申请日：2004-06-21

    申请人： Anupa R. Menjoge ,  Mohan G. Kulkarni

    发明人： Anupa R. Menjoge ,  Mohan G. Kulkarni

    IPC分类号： A61K9/24 ,  A61K9/14

    CPC分类号： A61K9/2866 ,  A61K9/284

    摘要： The present invention discloses coating compositions with taste masking property, comprising a blend of pH sensitive polymers and optionally a pH independent polymer or a blend of the pH sensitive polymer and pH independent polymer used for taste masking of highly bitter drugs. The pH sensitive polymers used comprise the acid soluble polymers and the enteric polymers. The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said coating compositions is disclosed. The concomitant use of the polymers inhibits the release of the bitter drug at the pH of saliva. The said coating compositions deliver substantial amount of the bitter drug immediately with improved palatability.

    摘要翻译： 本发明公开了具有掩味性质的涂料组合物，其包含pH敏感聚合物和任选的与pH无关的聚合物的混合物或用于高度苦味药物的味道掩蔽的pH敏感聚合物和与pH无关的聚合物的共混物。 所用的pH敏感聚合物包括酸溶性聚合物和肠溶聚合物。 公开了制备包含所述涂料组合物的苦味药物的掩味药物组合物的方法。 伴随使用聚合物抑制苦涩药物在唾液pH下的释放。 所述涂料组合物立即提供大量的苦味，具有改善的适口性。

    pH sensitive polymer and process for preparation thereof
    2.
    发明授权
    pH sensitive polymer and process for preparation thereof 失效
    pH敏感聚合物及其制备方法

    公开(公告)号：US07531612B2

    公开(公告)日：2009-05-12

    申请号：US10738949

    申请日：2003-12-19

    申请人： Mohan G. Kulkarni ,  Anupa R. Menjoge

    发明人： Mohan G. Kulkarni ,  Anupa R. Menjoge

    IPC分类号： C08F118/02

    CPC分类号： C08F246/00 ,  A61K9/2846 ,  A61K9/5026 ,  C08F220/12

    摘要： The present invention relates a novel pH sensitive polymer which exhibits pH dependant swelling/dissolution behavior. The composition is useful for taste masking of bitter drugs and also for the gastric delivery of the drugs. The said polymer comprises a hydrophobic monomer polymerized along with a basic monomer or a hydrophobic monomer polymerized along with a basic monomer and a hydrophilic monomer.

    摘要翻译： 本发明涉及一种具有pH依赖性溶胀/溶解行为的新型pH敏感性聚合物。 该组合物可用于苦味药物的掩味和用于胃输送药物。 所述聚合物包含与碱性单体一起聚合的疏水性单体或与碱性单体和亲水性单体一起聚合的疏水性单体。

    Pharmaceutical composition for improving palatability of drugs and process for preparation thereof
    3.
    发明授权
    Pharmaceutical composition for improving palatability of drugs and process for preparation thereof 有权
    用于改善药物适口性的药物组合物及其制备方法

    公开(公告)号：US07378109B2

    公开(公告)日：2008-05-27

    申请号：US11019648

    申请日：2004-12-23

    申请人： Anupa R. Menjoge ,  Mohan G. Kulkarni

    发明人： Anupa R. Menjoge ,  Mohan G. Kulkarni

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1617 ,  A61K9/1635

    摘要： The present invention discloses compositions, comprising a lipid-polymer matrix to mask the bitter or unpleasant taste of the medicament. The lipid or a blend of lipids, are used in combination with the pH dependent polymer where the said polymer is acid soluble or swellable The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said lipid-polymer compositions are disclosed. The concomitant use of the acid soluble polymer, which remains collapsed at the pH of saliva, inhibits the release of drug at that pH and hence they further help in bitterness inhibition. The said compositions deliver substantial amount of the bitter drug immediately at the gastric pH with improved palatability.

    摘要翻译： 本发明公开了包含脂质 - 聚合物基质以掩盖药物的苦味或不愉快味道的组合物。 脂质或脂质的混合物与pH依赖性聚合物组合使用，其中所述聚合物是酸溶性或可溶胀的。公开了制备包含所述脂质 - 聚合物组合物的苦味药物的掩味药物组合物的方法。 伴随使用酸溶性聚合物，其在唾液的pH下保持崩解，抑制药物在该pH下的释放，因此它们进一步有助于苦味抑制。 所述组合物立即在胃pH下提供大量的苦味药物，具有改善的适口性。

    DENDRIMER BASED NANODEVICES FOR THERAPEUTIC AND IMAGING PURPOSES
    5.
    发明申请
    DENDRIMER BASED NANODEVICES FOR THERAPEUTIC AND IMAGING PURPOSES 有权
    用于治疗和成像目的的基于DENDRIMER的纳米器件

    公开(公告)号：US20120003155A1

    公开(公告)日：2012-01-05

    申请号：US12797657

    申请日：2010-06-10

    申请人： Rangaramanujam M. Kannan ,  Sujatha Kannan ,  Roberto Romero ,  Raghavendra S. Navath ,  Hui Dai ,  Anupa R. Menjoge

    发明人： Rangaramanujam M. Kannan ,  Sujatha Kannan ,  Roberto Romero ,  Raghavendra S. Navath ,  Hui Dai ,  Anupa R. Menjoge

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61P29/00 ,  C08G69/48

    CPC分类号： A61K47/48215 ,  A61K31/198 ,  A61K31/405 ,  A61K31/43 ,  A61K31/57 ,  A61K31/573 ,  A61K31/65 ,  A61K38/10 ,  A61K47/595 ,  A61K47/60 ,  A61K47/64 ,  C08G83/004

    摘要： A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.

    摘要翻译： 提供包含与树枝状大分子连接的N-乙酰半胱氨酸的纳米设备组合物，例如PAMAM树枝状聚合物或多臂PEG聚合物。 还提供了用于将化合物靶向递送至需要治疗的位置的纳米设备。 纳米器件包括通过二硫键与化合物连接的PAMAM树枝状聚合物或多臂PEG聚合物。 提供了用于定位和递送治疗活性剂的纳米设备组合物，纳米设备包括PAMAM树枝状聚合物或多臂PEG聚合物和连接到PAMAM树枝状聚合物或多臂PEG聚合物的至少一种治疗活性剂。 通过使用二硫键将治疗活性剂附着到PAMAM树枝状聚合物或多臂PEG聚合物上来施用治疗活性剂的位点特异性递送方法，将PAMAM树枝状聚合物或多臂PEG聚合物施用于需要治疗的患者，将 树枝状大分子或多臂PEG聚合物连接到需要处理的部位，并在需要治疗的部位释放治疗活性剂。