公开(公告)号：US09211358B2

公开(公告)日：2015-12-15

申请号：US12450995

申请日：2008-04-23

申请人： Patrick J. Sinko ,  Stanley Stein ,  Anupa R. Menjoge ,  Simi Gunaseelan ,  Siva Naga Sree Priay Anumolu ,  Raghavandra Navath

发明人： Patrick J. Sinko ,  Stanley Stein ,  Anupa R. Menjoge ,  Simi Gunaseelan ,  Siva Naga Sree Priay Anumolu ,  Raghavandra Navath

IPC分类号： A61K47/30 ,  A61P17/02 ,  A61K38/18 ,  A61K38/06 ,  A61L15/22 ,  A61L26/00 ,  A61L15/26 ,  A61L15/44

CPC分类号： A61L26/0052 ,  A61L15/26 ,  A61L15/44 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/008 ,  A61L2300/204 ,  A61L2300/21 ,  A61L2300/25 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/602 ,  C08L71/02

摘要： Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.

摘要翻译： 描述了包含水溶性PEG聚合物的喷雾型水凝胶，其在原位交联以形成水凝胶，使得交联是可逆的。 水凝胶可用作药物递送组合物，伤口敷料或手术辅助剂。 聚乙二醇聚合物和交联剂溶液通过共同的孔口同时喷雾。 通过形成硫醚或二硫键的交联在混合时开始，提供快速凝胶化。 水凝胶组分可以用RGD肽或其类似物衍生，以促进保留在身体隔室中，例如皮肤，眼表或粘膜如阴道粘膜。 使用还原溶液使交联反转，从而易于通过溶解除去水凝胶。 还公开了制备交联剂，RGD衍生的PEG和RGD连接剂的方法。

公开(公告)号：US20110033503A1

公开(公告)日：2011-02-10

申请号：US12450995

申请日：2008-04-23

申请人： Patrick J. Sinko ,  Stanley Stein ,  Anupa R. Menjoge ,  Simi Gunaseelan ,  Siva Naga Sree priay Anumolu ,  Raghavandra Navath

发明人： Patrick J. Sinko ,  Stanley Stein ,  Anupa R. Menjoge ,  Simi Gunaseelan ,  Siva Naga Sree priay Anumolu ,  Raghavandra Navath

IPC分类号： A61K38/06 ,  A61K31/65 ,  A61K31/405 ,  A61K31/165 ,  A61K9/00 ,  A61K38/18 ,  A61K38/19 ,  A61K38/39 ,  A61P17/02 ,  A61K47/30

CPC分类号： A61L26/0052 ,  A61L15/26 ,  A61L15/44 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/008 ,  A61L2300/204 ,  A61L2300/21 ,  A61L2300/25 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/602 ,  C08L71/02

摘要： Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.

摘要翻译： 描述了包含水溶性PEG聚合物的喷雾型水凝胶，其在原位交联以形成水凝胶，使得交联是可逆的。 水凝胶可用作药物递送组合物，伤口敷料或手术辅助剂。 聚乙二醇聚合物和交联剂溶液通过共同的孔口同时喷雾。 通过形成硫醚或二硫键的交联在混合时开始，提供快速的凝胶化。 水凝胶组分可以用RGD肽或其类似物衍生，以促进保留在身体隔室中，例如皮肤，眼表或粘膜如阴道粘膜。 使用还原溶液使交联反转，从而易于通过溶解除去水凝胶。 还公开了制备交联剂，RGD衍生的PEG和RGD连接剂的方法。