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公开(公告)号：US09526794B2
公开(公告)日：2016-12-27
申请号：US13636715
申请日：2011-03-31
CPC分类号： A61K47/48207 , A61K9/0019 , A61K9/0051 , A61K31/43 , A61K47/595 , A61K47/6903 , C08G73/028 , C08L79/02
摘要： The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.
摘要翻译： 本发明公开了具有5nm至10μm尺寸范围内的交联纳米珠或颗粒形式的可注射水凝胶，其包含具有不对称外周端基的PAMAM树枝状聚合物，使得端基中的一个参与水凝胶的形成，而另一个 涉及药物或成像剂的结合及其制备方法。 所述凝胶通过PAMAM树枝状聚合物与不对称端基与其它聚合物的反应形成，其中另一种聚合物选自具有官能化端基的直链，支链，超支化或星形聚合物。 具有不对称端基的PAMAM树枝状聚合物由使用氨基酸或其修饰形式修饰的具有对称端基的第2代和更高级PAMAM树枝状聚合物组成。 本发明中公开的凝胶形成为尺寸范围为25nm至10μm的小交联颗粒，并且适用于通过肌肉内或皮下途径将水凝胶注射到任何身体孔，组织中，目的是为了 治疗和成像。
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2.发明授权Methods of determining whether a pregnant woman is at risk of developing preeclampsia 有权确定孕妇是否处于发生先兆子痫的风险的方法公开(公告)号：US07790463B2
公开(公告)日：2010-09-07
申请号：US11346694
申请日：2006-02-02
申请人： Gil G. Mor , Donna Neale , Roberto Romero
发明人： Gil G. Mor , Donna Neale , Roberto Romero
CPC分类号： G01N33/689 , G01N2500/00 , G01N2800/368
摘要： The present invention provides methods and compositions related to biomarker profiles for each trimester of pregnancy. The present invention also provides methods for identifying patients at risk of developing a complication of pregnancy, such as preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients with preeclampsia.
摘要翻译： 本发明提供了与妊娠三个月的生物标志物谱相关的方法和组合物。 本发明还提供了鉴定患有发生妊娠并发症的风险的患者的方法，例如先兆子痫。 在进一步的实施方案中，本发明涉及诊断先兆子痫患者的方法。
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公开(公告)号：US20120167231A1
公开(公告)日：2012-06-28
申请号：US12978051
申请日：2010-12-23
IPC分类号： G06F21/24
CPC分类号： G06F21/6218
摘要： Systems, methods and computer program products for controlling access to electronic content on a client device are provided. Whether access to electronic content is allowed or blocked is based on information and processes performed at the client device. Controlling access to electronic content on a client device can involve locally determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis performed by a remote device, such as a server. If a webpage is requested, for example, a client device may compare the URL address of the requested webpage, along with keywords and phrases found on the webpage, to locally-stored updateable lists of banned URL addresses and banned keywords and phrases to determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis.
摘要翻译： 提供了用于控制客户端设备上电子内容访问的系统，方法和计算机程序产品。 是否允许或阻止访问电子内容是基于在客户端设备执行的信息和处理。 控制对客户端设备上的电子内容的访问可以涉及本地确定是否允许，阻止对电子内容的访问，或将取决于远程设备（例如服务器）进行的进一步分析。 例如，如果请求了网页，客户端设备可以将所请求的网页的URL地址以及网页上找到的关键字和短语与本地存储的被禁止的URL地址的可更新列表和被禁止的关键字和短语进行比较，以确定是否 访问电子内容将被允许，阻止或将取决于进一步的分析。
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公开(公告)号：US20110010365A1
公开(公告)日：2011-01-13
申请号：US12498407
申请日：2009-07-07
CPC分类号： G06F17/3053 , G06F17/30882
摘要： Systems, methods and computer program products are provided for assigning content category scores to nodes of a linked database. The nodes of the linked database include linking nodes and linked nodes. Each linking node is assigned a linking node score for each content category. The linking node score for each content category represents a degree of relevancy of the linking node to the content category. Each of the linked nodes is linked to by at least one of the linking nodes. Each linked node is assigned a content category score for each content category. The content category score for each content category is based on the linking node score for said content category of each linking node that links to the linked node.
摘要翻译： 提供系统，方法和计算机程序产品，用于将内容类别分数分配给链接数据库的节点。 链接数据库的节点包括链接节点和链接节点。 为每个链接节点分配每个内容类别的链接节点分数。 每个内容类别的链接节点得分表示链接节点与内容类别的相关程度。 链接节点中的每一个被至少一个链接节点链接。 为每个链接节点分配每个内容类别的内容类别分数。 每个内容类别的内容类别分数基于链接到链接节点的每个链接节点的所述内容类别的链接节点得分。
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公开(公告)号：US07541182B2
公开(公告)日：2009-06-02
申请号：US10779360
申请日：2004-02-13
申请人： Gil G. Mor , Donna Neale , Roberto Romero
发明人： Gil G. Mor , Donna Neale , Roberto Romero
IPC分类号： C12N5/08
CPC分类号： G01N33/5091 , G01N2510/00
摘要： The present invention provides methods for identifying patients at risk of developing preeclampsia. In further embodiments, the present invention relates to methods for the diagnosis of patients with preeclampsia.
摘要翻译： 本发明提供了鉴定患有先兆子痫风险的患者的方法。 在进一步的实施方案中，本发明涉及诊断先兆子痫患者的方法。
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公开(公告)号：US08889101B2
公开(公告)日：2014-11-18
申请号：US12797657
申请日：2010-06-10
CPC分类号： A61K47/48215 , A61K31/198 , A61K31/405 , A61K31/43 , A61K31/57 , A61K31/573 , A61K31/65 , A61K38/10 , A61K47/595 , A61K47/60 , A61K47/64 , C08G83/004
摘要： A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.
摘要翻译： 提供包含与树枝状大分子连接的N-乙酰半胱氨酸的纳米设备组合物，例如PAMAM树枝状聚合物或多臂PEG聚合物。 还提供了用于将化合物靶向递送至需要治疗的位置的纳米设备。 纳米器件包括通过二硫键与化合物连接的PAMAM树枝状聚合物或多臂PEG聚合物。 提供了用于定位和递送治疗活性剂的纳米设备组合物，纳米设备包括PAMAM树枝状聚合物或多臂PEG聚合物和连接到PAMAM树枝状聚合物或多臂PEG聚合物的至少一种治疗活性剂。 通过使用二硫键将治疗活性剂附着到PAMAM树枝状聚合物或多臂PEG聚合物上来施用治疗活性剂的位点特异性递送方法，将PAMAM树状聚合物或多臂PEG聚合物施用于需要治疗的患者，将 树枝状大分子或多臂PEG聚合物连接到需要处理的部位，并在需要治疗的部位释放治疗活性剂。
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公开(公告)号：US08732857B2
公开(公告)日：2014-05-20
申请号：US12978051
申请日：2010-12-23
IPC分类号： G06F21/00
CPC分类号： G06F21/6218
摘要： Systems, methods and computer program products for controlling access to electronic content on a client device are provided. Whether access to electronic content is allowed or blocked is based on information and processes performed at the client device. Controlling access to electronic content on a client device can involve locally determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis performed by a remote device, such as a server. If a webpage is requested, for example, a client device may compare the URL address of the requested webpage, along with keywords and phrases found on the webpage, to locally-stored updateable lists of banned URL addresses and banned keywords and phrases to determining whether access to the electronic content will be allowed, blocked, or will depend upon further analysis.
摘要翻译： 提供了用于控制客户端设备上电子内容访问的系统，方法和计算机程序产品。 是否允许或阻止访问电子内容是基于在客户端设备执行的信息和处理。 控制对客户端设备上的电子内容的访问可以涉及本地确定是否允许，阻止对电子内容的访问，或将取决于远程设备（例如服务器）进行的进一步分析。 例如，如果请求了网页，客户端设备可以将所请求的网页的URL地址以及网页上找到的关键字和短语与本地存储的被禁止的URL地址的可更新列表和被禁止的关键字和短语进行比较，以确定是否 访问电子内容将被允许，阻止或将取决于进一步的分析。
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公开(公告)号：US20130136697A1
公开(公告)日：2013-05-30
申请号：US13636715
申请日：2011-03-31
申请人： Rangaramanujam M. Kannan , Sujatha Kannan , Roberto Romero , Raghavendra Navath , Anupa Menjoge
发明人： Rangaramanujam M. Kannan , Sujatha Kannan , Roberto Romero , Raghavendra Navath , Anupa Menjoge
IPC分类号： A61K47/48
CPC分类号： A61K47/48207 , A61K9/0019 , A61K9/0051 , A61K31/43 , A61K47/595 , A61K47/6903 , C08G73/028 , C08L79/02
摘要： The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.
摘要翻译： 本发明公开了可交联的纳米颗粒或粒径为5nm至10μm的颗粒的可注射水凝胶，其包含具有不对称外周端基的PAMAM树枝状聚合物，使得其中一个端基参与水凝胶的形成，而另一个 涉及药物或成像剂的结合及其制备方法。 所述凝胶通过PAMAM树枝状聚合物与不对称端基与其它聚合物的反应形成，其中另一种聚合物选自具有官能化端基的直链，支链，超支化或星形聚合物。 具有不对称端基的PAMAM树枝状聚合物由使用氨基酸或其修饰形式修饰的具有对称端基的第2代和更高级PAMAM树枝状聚合物组成。 本发明公开的凝胶形成为尺寸范围为25nm至10μm的小交联颗粒，并且适用于通过肌肉内或皮下途径将水凝胶注射到任何身体孔，组织中，目的是为了 治疗和成像。
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公开(公告)号：US08423554B2
公开(公告)日：2013-04-16
申请号：US12498407
申请日：2009-07-07
CPC分类号： G06F17/3053 , G06F17/30882
摘要： Systems, methods and computer program products are provided for assigning content category scores to nodes of a linked database. The nodes of the linked database include linking nodes and linked nodes. Each linking node is assigned a linking node score for each content category. The linking node score for each content category represents a degree of relevancy of the linking node to the content category. Each of the linked nodes is linked to by at least one of the linking nodes. Each linked node is assigned a content category score for each content category. The content category score for each content category is based on the linking node score for said content category of each linking node that links to the linked node.
摘要翻译： 提供系统，方法和计算机程序产品，用于将内容类别分数分配给链接数据库的节点。 链接数据库的节点包括链接节点和链接节点。 为每个链接节点分配每个内容类别的链接节点分数。 每个内容类别的链接节点得分表示链接节点与内容类别的相关程度。 链接节点中的每一个被至少一个链接节点链接。 为每个链接节点分配每个内容类别的内容类别分数。 每个内容类别的内容类别分数基于链接到链接节点的每个链接节点的所述内容类别的链接节点得分。
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10.发明申请公开(公告)号：US20120003155A1
公开(公告)日：2012-01-05
申请号：US12797657
申请日：2010-06-10
申请人： Rangaramanujam M. Kannan , Sujatha Kannan , Roberto Romero , Raghavendra S. Navath , Hui Dai , Anupa R. Menjoge
发明人： Rangaramanujam M. Kannan , Sujatha Kannan , Roberto Romero , Raghavendra S. Navath , Hui Dai , Anupa R. Menjoge
CPC分类号： A61K47/48215 , A61K31/198 , A61K31/405 , A61K31/43 , A61K31/57 , A61K31/573 , A61K31/65 , A61K38/10 , A61K47/595 , A61K47/60 , A61K47/64 , C08G83/004
摘要： A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.
摘要翻译： 提供包含与树枝状大分子连接的N-乙酰半胱氨酸的纳米设备组合物，例如PAMAM树枝状聚合物或多臂PEG聚合物。 还提供了用于将化合物靶向递送至需要治疗的位置的纳米设备。 纳米器件包括通过二硫键与化合物连接的PAMAM树枝状聚合物或多臂PEG聚合物。 提供了用于定位和递送治疗活性剂的纳米设备组合物，纳米设备包括PAMAM树枝状聚合物或多臂PEG聚合物和连接到PAMAM树枝状聚合物或多臂PEG聚合物的至少一种治疗活性剂。 通过使用二硫键将治疗活性剂附着到PAMAM树枝状聚合物或多臂PEG聚合物上来施用治疗活性剂的位点特异性递送方法，将PAMAM树枝状聚合物或多臂PEG聚合物施用于需要治疗的患者，将 树枝状大分子或多臂PEG聚合物连接到需要处理的部位，并在需要治疗的部位释放治疗活性剂。
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