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1.发明授权Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators 有权芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂公开(公告)号：US09464082B2
公开(公告)日：2016-10-11
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , C07D413/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
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2.发明申请ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS 有权ARYL和ARYLALKYL取代的吡唑并吡啶并吡啶酮作为抗氧化剂的炎症调节剂公开(公告)号：US20150225397A1
公开(公告)日：2015-08-13
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D471/04 , C07D231/54 , C07D413/04 , C07D403/04 , C07D417/04 , C07D239/70 , C07D401/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
摘要翻译： 本申请涉及：（a）式（I）化合物及其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m，n，X和Y如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别用于治疗和预防与氧化应激和炎症有关的疾病。
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公开(公告)号：US11192852B2
公开(公告)日：2021-12-07
申请号：US16701585
申请日：2019-12-03
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07C255/47 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D231/54
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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公开(公告)号：US11993574B2
公开(公告)日：2024-05-28
申请号：US17251295
申请日：2019-06-17
发明人： Xin Jiang , Melean Visnick , Christopher F. Bender , Gary Bolton , Bradley Caprathe , Chitase Lee , Brian Kornberg , Patrick O'Brien , Martha R. Hotema
IPC分类号： C07D231/54 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D231/54 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and RORγ. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.
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公开(公告)号：US11292781B2
公开(公告)日：2022-04-05
申请号：US16468054
申请日：2017-12-16
发明人： Xin Jiang , Christopher F. Bender , Melean Visnick , Martha R. Hotema , Zachary S. Sheldon , Chitase Lee , Bradley William Caprathe , Gary Bolton , Brian Kornberg
IPC分类号： A61P37/00 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D239/70 , C07D221/04 , C07D403/04 , C07D417/14 , A61P35/00 , A61P29/00
摘要： Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
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公开(公告)号：US11059792B2
公开(公告)日：2021-07-13
申请号：US15548909
申请日：2016-02-12
发明人： Xin Jiang , Bradley William Caprathe , Chitase Lee , Gary Bolton , Christopher F. Bender , Melean Visnick
IPC分类号： C07D235/08 , A61P29/00 , C07D235/02 , C07D235/10 , C07D235/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07C235/02
摘要： Disclosed herein are compounds of the formula: (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used as antioxidant inflammation modulators. In some aspects, the present disclosure provides methods wherein the compounds and composition described herein are used for the treatment of diseases and disorders associated with inflammation and cancer.
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7.发明授权Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators 有权吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂公开(公告)号：US09174941B2
公开(公告)日：2015-11-03
申请号：US13939818
申请日：2013-07-11
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
摘要翻译： 本文公开了新型抗氧化剂炎症调节剂，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物及其组合物的方法。
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公开(公告)号：US11827664B2
公开(公告)日：2023-11-28
申请号：US17055331
申请日：2019-05-14
发明人： Xin Jiang , Melean Visnick , Christopher F. Bender , Gary Bolton , Bradley Caprathe , Chitase Lee
IPC分类号： C07H15/203 , A61P25/02 , C07H1/00
CPC分类号： C07H15/203 , A61P25/02 , C07H1/00
摘要： Provided are biaryl amides and coumarin-based compounds with modified sugar groups for treatment of diseases associated with heat shock protein pathway. The compounds having the following formulas, wherein variables are as defined herein. Formulae (I), (II), (III), (IV), and (V), Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.
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公开(公告)号：US09884809B2
公开(公告)日：2018-02-06
申请号：US14877974
申请日：2015-10-08
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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公开(公告)号：US11814338B2
公开(公告)日：2023-11-14
申请号：US17457808
申请日：2021-12-06
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07D231/54 , C07C255/47 , C07D239/70 , C07D401/04 , C07D403/04 , C07D417/04 , C07D487/04 , C07D413/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula:
wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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