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公开(公告)号：US09370629B2
公开(公告)日：2016-06-21
申请号：US14675275
申请日：2015-03-31
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Krishnamohan Sharma
IPC分类号： A61M11/00 , A61M11/04 , A61M15/06 , B01B1/00 , C06B33/00 , C06B45/14 , C09K5/18 , F24J1/00 , A61M16/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
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公开(公告)号：US08991387B2
公开(公告)日：2015-03-31
申请号：US13783508
申请日：2013-03-04
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Krishnamohan Sharma
IPC分类号： A47J36/30 , F24J1/00 , A61M11/04 , A61M15/06 , B01B1/00 , C06B33/00 , C06B45/14 , C09K5/18 , A61M16/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
摘要翻译： 公开了能够快速加热的加热单元，药物供应单元和药物输送物品。 公开了一种加热单元，其包括基板和能够经受放置在基板内的放热金属氧化反应的固体燃料。 这些加热单元可以通过电阻，光学点火或敲击来致动。 还公开了药物供应单元和药物递送物品，其中固体燃料构造成将基底加热到足以快速热蒸发其上设置的药物的温度。
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公开(公告)号：US20150157635A1
公开(公告)日：2015-06-11
申请号：US14624311
申请日：2015-02-17
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61K31/519 , A61K31/235 , A61K9/00 , A61K31/4468
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided.
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。
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公开(公告)号：US20150265783A1
公开(公告)日：2015-09-24
申请号：US14675275
申请日：2015-03-31
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Krishnamohan Sharma
IPC分类号： A61M11/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
摘要翻译： 公开了能够快速加热的加热单元，药物供应单元和药物输送物品。 公开了一种加热单元，其包括基板和能够经受放置在基板内的放热金属氧化反应的固体燃料。 这些加热单元可以通过电阻，光学点火或敲击来致动。 还公开了药物供应单元和药物递送物品，其中固体燃料构造成将基底加热到足以快速热蒸发其上设置的药物的温度。
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公开(公告)号：US08955512B2
公开(公告)日：2015-02-17
申请号：US13851577
申请日：2013-03-27
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 该方法包括：（a）加热涂覆有包含药物的组合物以形成蒸气的基底，其中涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 另一方面，提供一种形成用于吸入治疗的气雾剂的方法，其中所述方法包括：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中所述蒸气具有 质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。
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公开(公告)号：US20130276779A1
公开(公告)日：2013-10-24
申请号：US13851577
申请日：2013-03-27
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61M11/02
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 该方法包括：（a）加热涂覆有包含药物的组合物以形成蒸气的基质，其中所述涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 另一方面，提供一种形成用于吸入治疗的气雾剂的方法，其中所述方法包括：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中所述蒸气具有 质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶
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公开(公告)号：US20130180516A1
公开(公告)日：2013-07-18
申请号：US13783508
申请日：2013-03-04
发明人： Ramesh Damani , Ron L. Hale , Daniel J. Myers , Reynaldo J. Quintana , Dennis W. Solas , Soonho Song , Pravin Soni , Curtis Tom , Krishnamohan Sharma
IPC分类号： F24J1/00
CPC分类号： A61M11/00 , A61M11/041 , A61M11/042 , A61M11/047 , A61M11/048 , A61M15/06 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/36 , A61M2205/364 , A61M2205/3653 , A61M2205/8268 , B01B1/005 , B65B29/10 , C06B33/00 , C06B45/14 , C09K5/18 , F23B2900/00003 , F23C2900/99008 , F24V30/00 , Y02E20/346
摘要： Heating units, drug supply units and drug delivery articles capable of rapid heating are disclosed. Heating units comprising a substrate and a solid fuel capable of undergoing an exothermic metal oxidation reaction disposed within the substrate are disclosed. These heating units can be actuated by electrical resistance, by optical ignition or by percussion. Drug supply units and drug delivery articles wherein a solid fuel is configured to heat a substrate to a temperature sufficient to rapidly thermally vaporize a drug disposed thereon are also disclosed.
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公开(公告)号：US09439907B2
公开(公告)日：2016-09-13
申请号：US14077015
申请日：2013-11-11
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
IPC分类号： A61K31/519 , A61K9/00 , A61M15/00 , B05B7/16 , B05B17/04 , A61M11/02 , A61K31/235 , A61K31/4468 , A61M11/00 , A61M16/00
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present application relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition of a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method involves: (a) heating a substrate coated with a composition of a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
摘要翻译： 本申请涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 该方法包括：（a）加热涂覆有药物组合物的基质以形成蒸气，其中涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在另一方面，提供了一种形成用于吸入治疗的气溶胶的方法，其中所述方法包括：（a）加热涂覆有药物组合物的底物以在小于100毫秒内形成蒸气，其中所述蒸气具有 质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。
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公开(公告)号：US20140066618A1
公开(公告)日：2014-03-06
申请号：US14077015
申请日：2013-11-11
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Daniel Mufson , Daniel D. Rogers , Soonho Song , Martin J. Wensley , Daniel J. Myers , Jeffrey A. McKinney , Reynaldo J. Quintana , Joshua D. Rabinowitz
CPC分类号： A61M11/044 , A61K9/007 , A61K9/0073 , A61K31/235 , A61K31/4468 , A61K31/485 , A61K31/519 , A61M11/001 , A61M11/02 , A61M15/00 , A61M15/0028 , A61M16/109 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04
摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μthick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method comprises: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy
摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 该方法包括：（a）加热涂覆有包含药物的组合物以形成蒸气的基底，其中所述涂覆的组合物为小于10度的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 另一方面，提供一种形成用于吸入治疗的气雾剂的方法，其中所述方法包括：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中所述蒸气具有 质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶
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