公开(公告)号：US20130059318A1

公开(公告)日：2013-03-07

申请号：US13519696

申请日：2010-12-28

Applicant: Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

Inventor： Etsuji Kaneko ,  Yuka Sasaki ,  Katsuhiro Mori ,  Yutaka Kanda ,  Mitsuo Satoh

IPC: C07K16/42 ,  C12N5/12 ,  C12N15/63 ,  G01N33/577 ,  C12N1/19 ,  C12N5/10 ,  C12P21/08 ,  C12N15/13 ,  C12N1/21

CPC classification number: C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

Abstract: An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

Abstract translation: 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

公开(公告)号：US08158760B2

公开(公告)日：2012-04-17

申请号：US12351695

申请日：2009-01-09

Applicant: Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

Inventor： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  A61K39/00

CPC classification number: C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Abstract translation: 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。

公开(公告)号：US08039595B2

公开(公告)日：2011-10-18

申请号：US12351635

申请日：2009-01-09

Applicant: Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

Inventor： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/395

CPC classification number: C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Abstract translation: 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。

公开(公告)号：US20110027271A1

公开(公告)日：2011-02-03

申请号：US12816918

申请日：2010-06-16

Applicant: Yutaka KANDA ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

Inventor： Yutaka KANDA ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC: A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  A61P37/08 ,  A61P29/00 ,  A61P37/02 ,  A61P31/12 ,  A61P31/04

CPC classification number: C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

公开(公告)号：US07846725B2

公开(公告)日：2010-12-07

申请号：US12060617

申请日：2008-04-01

Applicant: Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

Inventor： Yutaka Kanda ,  Mitsuo Satoh ,  Kazuyasu Nakamura ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Naoko Yamane ,  Emi Hosaka ,  Kazuya Yamano ,  Motoo Yamasaki ,  Nobuo Hanai

IPC: C12N5/07 ,  C12N5/16 ,  A01N43/04 ,  A61K31/70

CPC classification number: C12P21/005 ,  C07K16/1063 ,  C07K16/18 ,  C07K16/241 ,  C07K16/2812 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3084 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2319/30 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/90 ,  C12N15/8245 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12Y204/01068

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, wherein the expression of GDP-mannose 4,6-dehydrogenase is inhibited by RNA interference.

Abstract translation: 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 其中GDP-甘露糖4,6-脱氢酶的表达被RNA干扰抑制。

公开(公告)号：US20100196371A1

公开(公告)日：2010-08-05

申请号：US12645613

申请日：2009-12-23

Applicant: NOBUO HANAI ,  KAZUYASU NAKAMURA ,  EMI HOSAKA ,  MOTOO YAMASAKI ,  KAZUHISA UCHIDA ,  TOYOHIDE SHINKAWA ,  SUSUMU IMABEPPU ,  YUTAKA KANDA ,  NAOKO YAMANE ,  HIDEHARU ANAZAWA

Inventor： NOBUO HANAI ,  KAZUYASU NAKAMURA ,  EMI HOSAKA ,  MOTOO YAMASAKI ,  KAZUHISA UCHIDA ,  TOYOHIDE SHINKAWA ,  SUSUMU IMABEPPU ,  YUTAKA KANDA ,  NAOKO YAMANE ,  HIDEHARU ANAZAWA

IPC: A61K39/395

CPC classification number: C07K16/3084 ,  A61K2039/505 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2319/00 ,  C12P21/005 ,  G01N33/53

Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

Abstract translation: 本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子 活动。

公开(公告)号：US07691810B2

公开(公告)日：2010-04-06

申请号：US10959322

申请日：2004-10-07

Applicant: Tsuyoshi Yamada ,  Mitsuo Satoh ,  Yutaka Kanda ,  Kazuya Yamano

Inventor： Tsuyoshi Yamada ,  Mitsuo Satoh ,  Yutaka Kanda ,  Kazuya Yamano

IPC: A61K38/36 ,  C07K14/81 ,  C07K14/475

CPC classification number: C12N15/8257 ,  C07K14/8128 ,  C12P21/005

Abstract: The present invention provides a process for producing an antithrombin III composition comprising an antithrombin III molecule having complex type N-glycoside-linked sugar chains, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains.

Abstract translation: 本发明提供一种制备抗凝血酶III组合物的方法，其包含具有复合型N-糖苷连接的糖链的抗凝血酶III分子，其中复合型N-糖苷连接的糖链具有其中岩藻糖不与N结合的结构 乙酰葡萄糖胺在糖链的还原端。

公开(公告)号：US07655228B2

公开(公告)日：2010-02-02

申请号：US11686911

申请日：2007-03-15

Applicant: Nobuo Hanai ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Motoo Yamasaki ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Susumu Imabeppu ,  Yutaka Kanda ,  Naoko Yamane ,  Hideharu Anazawa

Inventor： Nobuo Hanai ,  Kazuyasu Nakamura ,  Emi Hosaka ,  Motoo Yamasaki ,  Kazuhisa Uchida ,  Toyohide Shinkawa ,  Susumu Imabeppu ,  Yutaka Kanda ,  Naoko Yamane ,  Hideharu Anazawa

IPC: A61K39/00 ,  A61K39/395

CPC classification number: C07K16/3084 ,  A61K2039/505 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2319/00 ,  C12P21/005 ,  G01N33/53

Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

Abstract translation: 本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子 活动。

公开(公告)号：US20090048253A1

公开(公告)日：2009-02-19

申请号：US11917239

申请日：2006-06-29

Applicant: Shinpei Yamaguchi ,  Takayuki Nakashima ,  Yutaka Kanda

Inventor： Shinpei Yamaguchi ,  Takayuki Nakashima ,  Yutaka Kanda

IPC: A61K31/5377 ,  C07D225/04 ,  A61K31/33 ,  A61P35/00 ,  A61K31/40

CPC classification number: C07D225/06 ,  C07F7/1804

Abstract: The present invention provides a benzenoid ansamycin derivative represented by Formula (I) (wherein R1 and R2 each represent a hydrogen atom or are combined together to form a bond, R8 represents a bond or an oxygen atom, R11 represents hydroxy, substituted or unsubstituted lower alkoxy or substituted or unsubstituted lower alkanoyloxy, R15 represents a hydrogen atom or methoxy, R22 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl or substituted or unsubstituted aroyl, R4 and R5 each represent a hydrogen atom or are combined together to form a bond, R18 represents a hydrogen atom, or the like, R21 represents hydroxy or the like, and R17 and R19 may be the same or different and each represents a hydrogen atom, or the like) or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供由式（I）表示的苯并安莎霉素衍生物（其中R1和R2各自表示氢原子或组合在一起形成键，R8表示键或氧原子，R11表示羟基，取代或未取代的低级 烷氧基或取代或未取代的低级烷酰氧基，R 15表示氢原子或甲氧基，R 22表示氢原子，取代或未取代的低级烷基，取代或未取代的低级烷酰基或取代或未取代的芳酰基，R4和R5各自表示氢原子或被结合 一起形成键，R 18表示氢原子等，R 21表示羟基等，R 17和R 19可以相同或不同，各自表示氢原子等）或其药学上可接受的盐 。

公开(公告)号：US20090042883A1

公开(公告)日：2009-02-12

申请号：US11816736

申请日：2006-02-21

Applicant: Yutaka Kanda ,  Shiro Soga ,  Takayuki Nakashima ,  Shinji Nara ,  Hiroshi Nakagawa ,  Yukimasa Shiotsu

Inventor： Yutaka Kanda ,  Shiro Soga ,  Takayuki Nakashima ,  Shinji Nara ,  Hiroshi Nakagawa ,  Yukimasa Shiotsu

IPC: A61K31/05 ,  C07C39/04 ,  C07D211/70 ,  C07D241/04 ,  A61K31/4406 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/5375 ,  A61K31/495 ,  C07D403/04 ,  C07D265/30 ,  C07D413/04

CPC classification number: A61K31/12 ,  A61K31/165 ,  A61K31/216 ,  A61K31/343 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4406 ,  A61K31/445 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  C07C235/78 ,  C07D207/09 ,  C07D207/24 ,  C07D207/27 ,  C07D211/22 ,  C07D211/42 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/50 ,  C07D217/06 ,  C07D239/42 ,  C07D241/18 ,  C07D295/088 ,  C07D295/13 ,  C07D295/185 ,  C07D307/14 ,  C07D307/46 ,  C07D307/52 ,  C07D317/60 ,  C07D333/22

Abstract: The present invention provides a therapeutic agent for a tumor selected from a hematopoietic tumor and a solid tumor which comprises, as an active ingredient, a benzoyl compound represented by General Formula (I): (wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8 or the like; R2 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R3 and R5 may be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl or the like), a prodrug thereof or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供一种选自造血肿瘤和实体肿瘤的肿瘤治疗剂，其包含通式（I）表示的苯甲酰基化合物作为活性成分：（其中n表示1〜5的整数; R1 表示取代或未取代的低级烷氧基，取代或未取代的低级烷氧基羰基，CONR 7 R 8等; R 2表示取代或未取代的芳基或取代或未取代的芳族杂环基; R 3和R 5可以相同或不同，各自表示氢原子， 取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6表示氢原子，卤素，取代或未取代的低级烷基等），其前药或其药学上可接受的盐。