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公开(公告)号：US20120177643A1
公开(公告)日：2012-07-12
申请号：US13428739
申请日：2012-03-23
申请人： Kenya Shitara , Kazuyasu Nakamura , Emi Hosaka , Akiko Shimizu , Masamichi Koike
发明人： Kenya Shitara , Kazuyasu Nakamura , Emi Hosaka , Akiko Shimizu , Masamichi Koike
IPC分类号： A61K39/395 , A61P37/00 , A61P35/02 , A61P37/08 , C12N5/0783 , A61P35/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/7158 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , G01N33/57492 , G01N33/6863 , G01N2333/4719 , G01N2333/7158
摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.
摘要翻译： 与人CC趋化因子受体4（CCR4）的细胞外区特异性反应但不与人血小板反应的人CDR-移植抗体或其抗体片段; 与CCR4的胞外区特异性反应并对CCR4表达细胞具有细胞毒活性的人CDR-移植抗体或其抗体片段; 以及包含至少一种抗体及其抗体片段作为活性成分的药物，治疗剂或诊断剂。
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2.发明授权Antibody composition exhibiting cellular cytotoxicity due to glycosylation and containing ganglioside GM2 binding antibody 有权抗体组合物由于糖基化而显示细胞毒性并含有神经节苷脂GM2结合抗体公开(公告)号：US08110195B2
公开(公告)日：2012-02-07
申请号：US12818735
申请日：2010-06-18
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Motoo Yamasaki , Nobuo Hanai , Emi Hosaka , Kazuya Yamano
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Motoo Yamasaki , Nobuo Hanai , Emi Hosaka , Kazuya Yamano
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody binding to ganglioside GM2, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如结合神经节苷脂GM2的抗体，抗体片段和具有抗体等Fc区的融合蛋白，抗体组合物的制备方法 使用细胞，抗体组合物及其用途。
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3.发明授权Anti-il-5 antibody composition exhibiting cellular cytotoxicity due to glycosylation 有权抗-Il-5抗体组合物由于糖基化而显示出细胞毒性公开(公告)号：US08101185B2
公开(公告)日：2012-01-24
申请号：US12818363
申请日：2010-06-18
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Motoo Yamasaki , Nobuo Hanai , Emi Hosaka , Kazuya Yamano
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Motoo Yamasaki , Nobuo Hanai , Emi Hosaka , Kazuya Yamano
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an anti-IL-5 antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于制备具有高抗体依赖性细胞介导的细胞毒活性的抗IL-5抗体分子的细胞，抗体的片段和具有抗体等的Fc区的融合蛋白， 使用该细胞产生抗体组合物的方法，抗体组合物及其用途。
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公开(公告)号：US20110052610A1
公开(公告)日：2011-03-03
申请号：US12818363
申请日：2010-06-18
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
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5.发明授权Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation 有权抗体组合物由于糖基化而表现出增加的细胞毒性公开(公告)号：US07741442B2
公开(公告)日：2010-06-22
申请号：US11218473
申请日：2005-09-06
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12P21/08 , C07K16/00 , A61K39/00 , A61K39/40 , A61K39/395
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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公开(公告)号：US07737325B2
公开(公告)日：2010-06-15
申请号：US11131212
申请日：2005-05-18
申请人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka Kanda , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-modulated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于制备抗体分子的细胞，例如可用于具有高抗体依赖性细胞调节细胞毒性活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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公开(公告)号：US07708992B2
公开(公告)日：2010-05-04
申请号：US11126298
申请日：2005-05-11
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to methods for modulating the antibody-dependent cellular cytotoxicity of an IgG antibody composition.
摘要翻译： 本发明涉及调节IgG抗体组合物的抗体依赖性细胞毒性的方法。
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8.发明授权公开(公告)号：US07651688B2
公开(公告)日：2010-01-26
申请号：US11686915
申请日：2007-03-15
申请人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
发明人： Nobuo Hanai , Kazuyasu Nakamura , Emi Hosaka , Motoo Yamasaki , Kazuhisa Uchida , Toyohide Shinkawa , Susumu Imabeppu , Yutaka Kanda , Naoko Yamane , Hideharu Anazawa
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C12P21/005 , G01N33/53
摘要： The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
摘要翻译： 本发明涉及一种控制免疫功能性分子如抗体，蛋白质，肽等的活性的方法，促进免疫功能性分子活性的试剂和具有促进作用的免疫功能分子 活动。
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公开(公告)号：US20090228994A1
公开(公告)日：2009-09-10
申请号：US12409587
申请日：2009-03-24
申请人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
发明人： Yutaka KANDA , Mitsuo Satoh , Kazuyasu Nakamura , Kazuhisa Uchida , Toyohide Shinkawa , Naoko Yamane , Emi Hosaka , Kazuya Yamano , Motoo Yamasaki , Nobuo Hanai
IPC分类号： C12P21/00 , A61K39/395 , C12P21/06 , C12P21/04 , C12N5/10 , A61K38/16 , C07K16/00 , C07K14/00 , A01K67/00 , A01K67/027
CPC分类号： C12P21/005 , C07K16/1063 , C07K16/18 , C07K16/241 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/3084 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/732 , C07K2319/30 , C12N9/0006 , C12N9/1051 , C12N9/90 , C12N15/8245 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12Y204/01068
摘要： The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
摘要翻译： 本发明涉及用于生产抗体分子的细胞，例如可用于具有高抗体依赖性细胞介导的细胞毒活性的各种疾病的抗体，抗体片段和具有抗体Fc区的融合蛋白，或 类似物，使用该细胞的抗体组合物的制备方法，抗体组合物及其用途。
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公开(公告)号：US07504104B2
公开(公告)日：2009-03-17
申请号：US10231452
申请日：2002-08-30
申请人： Kenya Shitara , Kazuyasu Nakamura , Emi Hosaka , Akiko Tanaka , Masamichi Koike
发明人： Kenya Shitara , Kazuyasu Nakamura , Emi Hosaka , Akiko Tanaka , Masamichi Koike
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/2896 , A61K2039/505 , C07K14/7158 , C07K16/2866 , C07K2317/24 , C07K2317/565 , C07K2317/732 , G01N33/57492 , G01N33/6863 , G01N2333/4719 , G01N2333/7158
摘要： A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.
摘要翻译： 与人CC趋化因子受体4（CCR4）的细胞外区特异性反应但不与人血小板反应的人CDR-移植抗体或其抗体片段; 与CCR4的胞外区特异性反应并对CCR4表达细胞具有细胞毒活性的人CDR-移植抗体或其抗体片段; 以及包含至少一种抗体及其抗体片段作为活性成分的药物，治疗剂或诊断剂。
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