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    Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production
    1.
    发明授权
    Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production 有权
    信号放大微球，它们用于一步法和多步分析扩增程序及其生产方法

    公开(公告)号：US09151748B2

    公开(公告)日：2015-10-06

    申请号：US13375108

    申请日：2010-06-10

    申请人： Wing Cheung Mak ,  Ling Wai Wong ,  Pui Yee Cangel Chan ,  Reinhard Renneberg

    发明人： Wing Cheung Mak ,  Ling Wai Wong ,  Pui Yee Cangel Chan ,  Reinhard Renneberg

    IPC分类号： A61K9/50 ,  G01N33/543

    CPC分类号： G01N33/54313

    摘要： The present invention relates to microspheres comprising protein signal precursor molecules, or a carrier protein bonded to signal precursor molecules, wherein said signal precursor molecules are activatable to generate a detectable signal whilst remaining bonded to the carrier protein. Also disclosed is a method of making such microspheres comprising the steps of mixing protein molecules with a matrix former in solution; adding a reducing reagent to the mixture; removing the reducing reagent; and removing the matrix former to leave microspheres of protein molecules. Also disclosed are bioassay methods using the microspheres to provide signal amplification, including an amplification cycling procedure.

    摘要翻译： 本发明涉及包含蛋白质信号前体分子或与信号前体分子结合的载体蛋白的微球，其中所述信号前体分子可激活以产生可检测信号，同时保持与载体蛋白结合。 还公开了制备这种微球的方法，其包括将蛋白质分子与溶液中的基质原料混合的步骤; 向混合物中加入还原剂; 去除还原剂; 并去除基质原子以留下蛋白质分子的微球。 还公开了使用微球体提供信号放大的生物测定方法，包括扩增循环程序。

    SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION
    2.
    发明申请
    SIGNAL AMPLIFICATION MICROSPHERES, THEIR USE IN ONE-STEP AND MULTI-STEP ANALYTICAL AMPLIFICATION PROCEDURES AND METHODS FOR THEIR PRODUCTION 有权
    信号放大微球，它们在一步和多步分析放大过程中的应用及其生产方法

    公开(公告)号：US20120171747A1

    公开(公告)日：2012-07-05

    申请号：US13375108

    申请日：2010-06-10

    申请人： Wing Cheung Mak ,  Ling Wai Wong ,  Pui YeeCangel Chan ,  Reinhard Renneberg

    发明人： Wing Cheung Mak ,  Ling Wai Wong ,  Pui YeeCangel Chan ,  Reinhard Renneberg

    IPC分类号： C07K19/00 ,  C07K16/00 ,  C07K14/435 ,  C12N9/96 ,  C07K14/00 ,  C07K1/107

    CPC分类号： G01N33/54313

    摘要： The present invention relates to microspheres comprising protein signal precursor molecules, or a carrier protein bonded to signal precursor molecules, wherein said signal precursor molecules are activatable to generate a detectable signal whilst remaining bonded to the carrier protein. Also disclosed is a method of making such microspheres comprising the steps of mixing protein molecules with a matrix former in solution; adding a reducing reagent to the mixture; removing the reducing reagent; and removing the matrix former to leave microspheres of protein molecules. Also disclosed are bioassay methods using the microspheres to provide signal amplification, including an amplification cycling procedure.

    摘要翻译： 本发明涉及包含蛋白质信号前体分子或与信号前体分子结合的载体蛋白的微球，其中所述信号前体分子可激活以产生可检测信号，同时保持与载体蛋白结合。 还公开了制备这种微球的方法，其包括将蛋白质分子与溶液中的基质原料混合的步骤; 向混合物中加入还原剂; 去除还原剂; 并去除基质原子以留下蛋白质分子的微球。 还公开了使用微球体提供信号放大的生物测定方法，包括扩增循环程序。

    Apparatus for processing digital images
    6.
    发明申请
    Apparatus for processing digital images 审中-公开
    用于处理数字图像的装置

    公开(公告)号：US20070019072A1

    公开(公告)日：2007-01-25

    申请号：US10628745

    申请日：2003-07-28

    申请人： Robert Bengtsson ,  Kwun-Wing Cheung

    发明人： Robert Bengtsson ,  Kwun-Wing Cheung

    IPC分类号： H04N7/18

    CPC分类号： B64D11/00151 ,  B60N2/879 ,  B64D11/0015 ,  B64D11/00155

    摘要： A vehicle seat for supporting a passenger of a vehicle. The seat includes a seat frame having a mount for mounting the frame to the vehicle, a support extending from the mount, a seat bottom mounted on the support for supporting the passenger when occupying the seat, and a seat back extending upward from the seat bottom. The seat back has a front surface oriented to face the passenger occupying the seat and a rear surface opposite the front surface. A video monitor is mounted on the seat frame, and a digital processor is operatively connected to the video monitor for processing a digital input for display as an image on the video monitor.

    摘要翻译： 一种用于支撑车辆乘客的车辆座椅。 所述座椅包括座架，所述座架具有用于将所述框架安装到所述车辆的安装座，从所述安装座延伸的支撑件，安装在所述支撑件上的座椅底座，用于在占据所述座椅时支撑乘客;以及座椅靠背，其从所述座椅底部向上延伸 。 座椅靠背具有朝向乘客占据座椅的前表面和与前表面相对的后表面。 视频监视器安装在座椅框架上，并且数字处理器可操作地连接到视频监视器，用于处理数字输入以在视频监视器上显示为图像。

    Combination dosing regimen for erythropoietin
    7.
    发明申请
    Combination dosing regimen for erythropoietin 审中-公开
    红细胞生成素联合给药方案

    公开(公告)号：US20050267026A1

    公开(公告)日：2005-12-01

    申请号：US11088284

    申请日：2005-03-24

    申请人： Wing Cheung

    发明人： Wing Cheung

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1816

    摘要： The present invention provides a combination dosing regimen for erythropoietin (EPO). More particularly, the present dosing regimen includes administration of at least a first dosing segment comprising a first exposure to EPO capable of stimulating the production of reticulocytes followed by a second exposure to EPO capable of sustaining the maturation of the reticulocytes into neocytes, and ultimately, red blood cells. Advantageously, the dosing segment may be cycled or repeated, any number of times and according to any desired time scheme, in order to provide or maintain any desired total red blood cell count and/or hemoglobin concentration. Methods of treatment employing the combination dosing regimen, as well as kits are also provided.

    摘要翻译： 本发明提供促红细胞生成素（EPO）的组合给药方案。 更具体地，本发明的给药方案包括施用至少第一给药段，其包含能够刺激网织红细胞生成的EPO的第一次暴露，然后第二次暴露于能够维持网织红细胞成熟为新细胞的EPO， 红细胞。 有利地，给药段可以循环或重复任意次数，并且根据任何期望的时间方案，以便提供或维持任何期望的总红细胞计数和/或血红蛋白浓度。 还提供了使用联合给药方案的治疗方法以及试剂盒。

    Alignment device with multiple spring systems
    10.
    发明授权
    Alignment device with multiple spring systems 失效
    具有多个弹簧系统的定位装置

    公开(公告)号：US06804892B1

    公开(公告)日：2004-10-19

    申请号：US10402329

    申请日：2003-03-28

    申请人： Bill Wai Lam Yung ,  Jonathan Wing Cheung Lam ,  Weng Chia Tang

    发明人： Bill Wai Lam Yung ,  Jonathan Wing Cheung Lam ,  Weng Chia Tang

    IPC分类号： G01C1500

    CPC分类号： G01C15/004

    摘要： An alignment device provides one or more references, such as laser lines and planes in horizontal and vertical orientations. One version of the alignment device includes an optics mounting assembly situated in a pivot socket on a frame to provide an output beam. Multiple spring systems and one or more alignment assemblies align and secure the optics mounting assembly in the socket. As a result, the output beam has a desired orientation with respect to true level. A first spring system directs the optics mounting assembly through the pivot socket. A second spring system holds the optics mounting assembly in communication with the alignment assemblies to reduce system backlash. One implementation of the pivot socket has a surface in the form of a sphere's interior surface. A set of support members on the optics mounting assembly rest on the pivot socket's spherical surface—causing the output reference beam to extend from the center of a sphere including the socket's spherical surface. This reduces the translation of the output reference beam's origin when the optics mounting assembly pivots in the socket.

    摘要翻译： 对准装置提供一个或多个参考，例如水平和垂直取向的激光线和平面。 对准装置的一个版本包括位于框架上的枢轴插座中以提供输出光束的光学器件安装组件。 多个弹簧系统和一个或多个对准组件将光学安装组件对准并固定在插座中。 结果，输出光束相对于真实电平具有期望的取向。 第一弹簧系统通过枢轴插座引导光学安装组件。 第二弹簧系统将光学安装组件保持与对准组件连通以减少系统间隙。 枢轴套筒的一个实施例具有球体内表面形式的表面。 光学安装组件上的一组支撑构件位于枢轴插座的球面上，使得输出参考光束从包括插座的球面的球体的中心延伸。 当光学安装组件在插座中枢转时，这减小了输出参考光束原点的平移。