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    Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
    1.
    发明授权
    Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone 失效
    吡啶并[2,3-d]嘧啶酮和咪唑并[4,5-b]嘧啶酮

    公开(公告)号：US4859672A

    公开(公告)日：1989-08-22

    申请号：US925008

    申请日：1986-10-29

    Applicant: Alfred P. Spada ,  Henry F. Campbell ,  Donald E. Kuhla ,  William L. Studt ,  William C. Faith ,  Bruce F. Molino

    Inventor： Alfred P. Spada ,  Henry F. Campbell ,  Donald E. Kuhla ,  William L. Studt ,  William C. Faith ,  Bruce F. Molino

    IPC: C07D475/02 ,  A61K31/435 ,  A61K31/44 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61K31/519 ,  A61K31/53 ,  A61K31/55 ,  A61P37/04 ,  C07D471/04 ,  C07D475/00 ,  C07D487/04

    CPC classification number: C07D475/00 ,  C07D471/04

    Abstract: Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.10, R.sub.11, R.sub.12, R.sub.14, R.sub.15, R.sub.16, R.sub.17, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms;wherein the substituted phenyl group is substituted by one or more of lower alkyl, lower alkoxy, amino, lower alkyl amino, lower alkyl mercapto, hydroxy, hydroxy lower alkyl, acetoxy, benzyloxy, phenoxy, lower alkyl sulfinyl or lower alkyl sulfonyl;R.sub.13 is H, lower alkyl of 1-4 carbon atoms, alkoxy lower alkyl of 1-4 carbon atoms, hydroxy lower alkyl of 1-5 carbon atoms, amino, carbamoyl, cyano, lower alkyl carbamoyl of 1-4 carbon atoms, formyl, amino lower alkyl of 1-4 carbon atoms, carboxy, carbalkoxy, or tetrazolyl;R.sub.3 and R.sub.4 together may form =O;R.sub.16 and R.sub.17 together may form a carbon-carbon bond;n is 0 or 1; andO is 0 or 1.

    Abstract translation: 公开了可用于增加人或其他动物的强心收缩性的化合物和包括这些化合物的药物组合物。 这些化合物具有通用结构，其中：A为 + TR ，R1，R2，R3，R4，R8，R10，R11，R12，R14，R15，R16，R17，R18， R 20，R 21，R 22，R 23和R 24是H，1-4个碳原子的低级烷基，苯基，取代的苯基，1-4个碳原子的苯基低级烷基或1-4个碳原子的取代的苯基低级烷基; 其中取代的苯基被一个或多个低级烷基，低级烷氧基，氨基，低级烷基氨基，低级烷基巯基，羟基，羟基低级烷基，乙酰氧基，苄氧基，苯氧基，低级烷基亚磺酰基或低级烷基磺酰基取代。 R13为H，1-4个碳原子的低级烷基，1-4个碳原子的烷氧基低级烷基，1-5个碳原子的羟基低级烷基，氨基，氨基甲酰基，氰基，1-4个碳原子的低级烷基氨基甲酰基， ，1-4个碳原子的氨基低级烷基，羧基，烷氧羰基或四唑基; R3和R4一起可以形成= O; R 16和R 17一起可以形成碳 - 碳键; n为0或1; O为0或1。

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