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公开(公告)号：US4443456A
公开(公告)日：1984-04-17
申请号：US262808
申请日：1981-05-12
IPC分类号： C07D207/06 , C07D207/09 , C07D207/32 , C07D207/325 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/12 , C07D217/14 , C07D233/54 , C07D239/26 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/52 , C07D333/20 , C07D333/30 , C07D333/38 , C07D521/00 , A61K31/44 , C07D213/46
CPC分类号： C07D207/325 , C07D207/06 , C07D207/09 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/12 , C07D217/14 , C07D231/12 , C07D233/56 , C07D233/64 , C07D239/26 , C07D249/08 , C07D261/08 , C07D263/32 , C07D265/30 , C07D275/02 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/52 , C07D333/20 , C07D333/30 , C07D333/38 , Y10S514/818 , Y10S514/821 , Y10S514/867 , Y10S514/895 , Y10S514/926 , Y10S514/927
摘要： This invention relates to a novel class of amidinourea and amidinothiourea compounds wherein the urea nitrogen atom is substituted by a heterocyclic alkylene group, and their use in pharmaceutical preparations which are useful for producing anti-ulcerogenic, antisecretory, antispasmodic, antihypertensive, anesthetic, anti-arrhythmic, antidiarrheal and antiparasitic action.
摘要翻译： 本发明涉及一类新型的脒基脲和脒基硫脲化合物，其中尿素氮原子被杂环亚烷基取代，以及它们在制备抗溃疡，抗分泌，解痉，抗高血压，麻醉， 心律失常，止泻和反寄生作用。
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2.发明授权
公开(公告)号：US4242337A
公开(公告)日：1980-12-30
申请号：US1638
申请日：1979-01-08
IPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , A61K31/535 , A61K31/17 , A61K31/42 , A61K31/445
CPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , Y10S514/867 , Y10S514/925
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
摘要翻译： 描述了一类新的化合物及其制备方法。 这些化合物具有抗分泌，抗痉挛，抗溃疡和抗腹泻剂的有价值的特性。
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公开(公告)号：US4440949A
公开(公告)日：1984-04-03
申请号：US221453
申请日：1980-12-30
IPC分类号： C07D261/02 , C07D265/06 , C07C99/02 , C07C127/15 , C07C127/19
CPC分类号： C07D261/02 , C07D265/06
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
摘要翻译： 描述了一类新的化合物及其制备方法。 这些化合物具有抗分泌，抗痉挛，抗溃疡和抗腹泻剂的有价值的特性。
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4.发明授权Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals 失效治疗哺乳动物胃肠道分泌和溃疡性疾病状况或症状的方法
公开(公告)号：US4169155A
公开(公告)日：1979-09-25
申请号：US934780
申请日：1978-08-18
IPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , A61K31/17 , A61K31/535
CPC分类号： C07D209/48 , C07D261/02 , C07D265/06
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
摘要翻译： 描述了一类新的化合物及其制备方法。 这些化合物具有抗分泌，抗痉挛，抗溃疡和抗腹泻剂的有价值的特性。
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公开(公告)号：US4452980A
公开(公告)日：1984-06-05
申请号：US394128
申请日：1982-07-01
IPC分类号： C07D251/16 , C07D251/42
CPC分类号： C07D251/16
摘要： Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
摘要翻译： 通过与活化形式的酰胺反应制备新颖的s-三嗪化合物作为相应的脒基脲和脒基硫脲化合物的衍生物，分别得到下式的取代的S-三嗪酮和硫酮：s-三嗪酮和硫酮是有用的 衍生物分析相应的脒基脲或脒基硫脲前体，并且还具有有用的药理学性质，使其适用于多种药用目的，包括用作抗腹泻剂。
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6.发明授权Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals 失效治疗哺乳动物胃肠道痉挛症状况或症状的方法
公开(公告)号：US4242339A
公开(公告)日：1980-12-30
申请号：US1636
申请日：1979-01-08
IPC分类号： C07D261/02 , C07D265/06 , A61K31/535 , A61K31/17 , A61K31/42 , A61K31/445
CPC分类号： C07D261/02 , C07D265/06 , Y10S514/867 , Y10S514/925
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
摘要翻译： 描述了一类新的化合物及其制备方法。 这些化合物具有抗分泌，抗痉挛，抗溃疡和抗腹泻剂的有价值的特性。
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7.发明授权Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals 失效治疗哺乳动物胃肠道分泌和溃疡性疾病状况或症状的方法
公开(公告)号：US4242338A
公开(公告)日：1980-12-30
申请号：US1668
申请日：1979-01-08
IPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , A61K31/42
CPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , Y10S514/867 , Y10S514/925
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
摘要翻译： 描述了一类新的化合物及其制备方法。 这些化合物具有抗分泌，抗痉挛，抗溃疡和抗腹泻剂的有价值的特性。
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公开(公告)号：US4387225A
公开(公告)日：1983-06-07
申请号：US262809
申请日：1981-05-12
IPC分类号： C07D251/16 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D521/00 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D251/16 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： Heterocyclic alkyl s-triazine compounds are prepared from the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give respectively substituted s-triazinones and thiones of the formula ##STR1## which have pharmacological properties that render them suitable for use for a variety of medicinal purposes, including use as antidiarrheal agents, and which are also useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors.
摘要翻译： 由相应的脒基脲和脒基硫脲化合物通过与活化形式的酰胺反应制备杂环烷基s-三嗪化合物，得到分别具有使其适合使用的药理学性质的式“IMAGE”的取代的S-三嗪酮和硫堇 用于各种药用目的，包括用作止泻药，并且也用于分析相应的脒基脲或脒基硫脲前体的有用衍生物。
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公开(公告)号：US4246409A
公开(公告)日：1981-01-20
申请号：US959611
申请日：1978-11-13
IPC分类号： A61K31/53 , A61P1/04 , A61P1/10 , A61P1/12 , C07D251/16 , C07D401/04 , C07D401/12 , C07D251/42 , C07D413/04 , C07D413/14 , C07D417/04
CPC分类号： C07D251/16
摘要： Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
摘要翻译： 通过与活化形式的酰胺反应制备新颖的s-三嗪化合物作为相应的脒基脲和脒基硫脲化合物的衍生物，分别得到下式的取代的S-三嗪酮和硫酮：s-三嗪酮和硫酮是有用的 衍生物分析相应的脒基脲或脒基硫脲前体，并且还具有有用的药理学性质，使其适用于多种药用目的，包括用作抗腹泻剂。
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10.发明授权
公开(公告)号：US4218450A
公开(公告)日：1980-08-19
申请号：US1637
申请日：1979-01-08
IPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , A61K31/535 , A61K31/42
CPC分类号： C07D209/48 , C07D261/02 , C07D265/06 , Y10S514/867 , Y10S514/925
摘要： A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
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