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公开(公告)号：US20070265227A1
公开(公告)日：2007-11-15
申请号：US11669547
申请日：2007-01-31
Applicant: Walid Heneine , Thomas Folks , Robert Janssen , Ronald Otten , J. Garcia-Lerma
Inventor： Walid Heneine , Thomas Folks , Robert Janssen , Ronald Otten , J. Garcia-Lerma
IPC: A61K31/52 , A61K31/505 , A61K31/675 , A61P31/18
CPC classification number: A61K31/675 , A61K9/0034 , A61K9/0053 , A61K31/513 , A61K31/683 , A61K31/7072 , A61K45/06 , A61K2300/00
Abstract: A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.
Abstract translation: 提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。 在暴露于免疫缺陷型逆转录病毒之前，通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。 如果在暴露后24小时内以单一剂量提供，则该药物是有效的。 定期日剂量的方案对于在感染灵长类动物宿主之后提供免疫缺陷型逆转录病毒变得自我复制的保护也是有效的。用于控制群体内的逆转录病毒传播的方法包括向接种免疫缺陷型逆转录病毒感染的高风险的亚群施用 性暴露于免疫缺陷型逆转录病毒来源之前的详细组合，以排除免疫缺陷逆转录病毒在亚群中成为自我复制。
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公开(公告)号：US20100317034A1
公开(公告)日：2010-12-16
申请号：US12829125
申请日：2010-07-01
Applicant: William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi Ngole
Inventor： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi Ngole
IPC: G01N33/53 , C07K14/005 , C07K16/08
CPC classification number: C12Q1/701 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/14021 , C12N2740/14022 , C12N2740/14043 , C12Q1/70
Abstract: Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.
Abstract translation: 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。
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公开(公告)号：US07794998B2
公开(公告)日：2010-09-14
申请号：US11678596
申请日：2007-02-24
Applicant: William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi Ngole
Inventor： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi Ngole
CPC classification number: C12Q1/701 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/14021 , C12N2740/14022 , C12N2740/14043 , C12Q1/70
Abstract: Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.
Abstract translation: 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。
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4.发明授权Methods and devices for detection of xenogeneic graft persistence and infectious agents 失效用于检测异种移植物持久性和感染因子的方法和装置公开(公告)号：US06566102B1
公开(公告)日：2003-05-20
申请号：US09743954
申请日：2001-01-12
Applicant: William M. Switzer , Walid Heneine , Shanmugam Vedapuri
Inventor： William M. Switzer , Walid Heneine , Shanmugam Vedapuri
IPC: C12P1934
CPC classification number: C12Q1/6888 , C12Q1/702 , C12Q2600/158
Abstract: Compositions, methods and diagnostic devices for monitoring graft integrity in xenotransplantation and for detecting infectious agents transmitted by the xenograft are described. In particular, the compositions, methods and devices are useful for determining porcine xenograft integrity and persistence and can detect the presence of PERV (porcine endogenous retrovirus) in a biological sample. The compositions, methods and devices are useful for determining or monitoring graft survival and rejection in recipients of xenografts and are useful for detecting the presence of pig cell and PERV infection in a xenotransplant recipient or donor. In addition, the compositions, methods and devices are useful for screening therapeutic products to be administered to humans to ensure that the products are free of pig cells, and thus free of PERV contamination, prior to administration.
Abstract translation: 描述了用于监测异种移植中的移植物完整性并检测由异种移植物传播的感染因子的组合物，方法和诊断装置。 特别地，组合物，方法和装置可用于确定猪异种移植物完整性和持久性，并且可以检测生物样品中PERV（猪内源性逆转录病毒）的存在。 组合物，方法和装置可用于确定或监测异种移植物接受者的移植物存活和排异，并且可用于检测异种移植受体或供体中猪细胞和PERV感染的存在。 此外，组合物，方法和装置可用于筛选待给予人的治疗产品，以确保产品在施用之前不含猪细胞，因此不含PERV污染。
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公开(公告)号：US08663968B2
公开(公告)日：2014-03-04
申请号：US12600995
申请日：2008-05-20
Applicant: William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , David M. Sintasath
Inventor： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , David M. Sintasath
CPC classification number: C07K14/005 , C07K16/1036 , C12N7/00 , C12N15/86 , C12N2740/14021 , C12N2740/14022 , C12N2740/14043 , G01N33/56983
Abstract: Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which included isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed.
Abstract translation: 公开了3型亚型T型细胞淋巴细胞病毒（STLV-3亚型D），编码STLV-3亚型D多肽的分离的核酸分子，例如STLV-3亚型D包膜，蛋白酶，聚合酶，tax，rex， 和衣壳多肽，由这种核酸编码的分离的多肽。 还公开了用于检测STLV-3亚型D的方法，例如通过检测样品中的STLV-3亚型D核酸或多肽。 因此，公开了用于检测STLV-3亚型D核酸或多肽的探针，引物和抗体。 还公开了包含编码STLV-3亚型D多肽的分离的核酸分子或由这种核酸分子编码的分离的多肽的治疗组合物。
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Patent Agency Ranking
6.发明授权Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs 有权用于检测抗病毒药物的HIV-1抗性的实时PCR点突变测定公开(公告)号：US08318428B2
公开(公告)日：2012-11-27
申请号：US13253463
申请日：2012-01-24
Applicant: Jeffrey A. Johnson , Walid Heneine
Inventor： Jeffrey A. Johnson , Walid Heneine
CPC classification number: C12Q1/703 , C12Q2600/156 , Y10S435/975
Abstract: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS:1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein.
Abstract translation: 公开了包括引物和探针的组合物，其能够与所公开的核酸相互作用，例如本文公开的编码HIV逆转录酶或蛋白酶的核酸。 因此，提供了包含SEQ ID NO：1-89和96-104中设置的任何一个核苷酸序列的寡核苷酸。 还提供了由SEQ ID NO：1-89和96-104所示的核苷酸组成的寡核苷酸。 所公开的寡核苷酸中的每一个都是探针或引物。 还提供了引物和探针的混合物，并且用于本文公开的RT-PCR和初级PCR反应。 提供了特异性检测HIV突变的方法。 可以使用本文所述的方法检测逆转录酶和HIV蛋白酶的突变。
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7.发明授权Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs 有权用于检测抗病毒药物的HIV-1抗性的实时PCR点突变测定公开(公告)号：US08043809B2
公开(公告)日：2011-10-25
申请号：US11570138
申请日：2005-06-07
Applicant: Jeffrey A. Johnson , Walid Heneine
Inventor： Jeffrey A. Johnson , Walid Heneine
CPC classification number: C12Q1/703 , C12Q2600/156 , Y10S435/975
Abstract: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS:1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein.
Abstract translation: 公开了包括引物和探针的组合物，其能够与所公开的核酸相互作用，例如本文公开的编码HIV逆转录酶或蛋白酶的核酸。 因此，提供了包含SEQ ID NO：1-89和96-104中设置的任何一个核苷酸序列的寡核苷酸。 还提供了由SEQ ID NO：1-89和96-104所示的核苷酸组成的寡核苷酸。 所公开的寡核苷酸中的每一个都是探针或引物。 还提供了引物和探针的混合物，并且用于本文公开的RT-PCR和初级PCR反应。 提供了特异性检测HIV突变的方法。 可以使用本文所述的方法检测逆转录酶和HIV蛋白酶的突变。
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公开(公告)号：US6136534A
公开(公告)日：2000-10-24
申请号：US123012
申请日：1998-07-27
Applicant: Walid Heneine , Thomas M. Folks , William M. Switzer , Shinji Yamamoto
Inventor： Walid Heneine , Thomas M. Folks , William M. Switzer , Shinji Yamamoto
CPC classification number: C12Q1/702
Abstract: The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will anneal and a DNA strand will be synthesized as an extension from the DNA primer if reverse transcriptase is present in the sample; b) amplifying the synthesized DNA; and c) detecting the amplification of the synthesized DNA, the amplification of the synthesized DNA indicating the presence of reverse transcriptase in the biological sample, thus indicating the presence of a retrovirus in the biological sample.
Abstract translation: 本发明提供了一种用于检测生物样品中逆转录病毒的存在的方法，包括以下步骤：a）在RNA模板和DNA引物将退火的条件下使生物样品与RNA模板和互补DNA引物接触， 如果样品中存在逆转录酶，DNA链将作为DNA引物的延伸进行合成; b）扩增合成的DNA; 和c）检测合成DNA的扩增，合成DNA的扩增，表明在生物样品中存在逆转录酶，从而表明生物样品中存在逆转录病毒。
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公开(公告)号：US5849494A
公开(公告)日：1998-12-15
申请号：US763762
申请日：1996-12-11
Applicant: Walid Heneine , Thomas M. Folks , William Marshall Switzer , Shinji Yamamoto
Inventor： Walid Heneine , Thomas M. Folks , William Marshall Switzer , Shinji Yamamoto
CPC classification number: C12Q1/702
Abstract: The present invention provides a method for detecting the presence of a retrovirus in a biological sample comprising the steps of: a) contacting the biological sample with an RNA template and a complementary DNA primer under conditions whereby the RNA template and the DNA primer will anneal and a DNA strand will be synthesized as an extension from the DNA primer if reverse transcriptase is present in the sample; b) amplifying the synthesized DNA; and c) detecting the amplification of the synthesized DNA, the amplification of the synthesized DNA indicating the presence of reverse transcriptase in the biological sample, thus indicating the presence of a retrovirus in the biological sample.
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公开(公告)号：US20080292657A1
公开(公告)日：2008-11-27
申请号：US11678596
申请日：2007-02-24
Applicant: William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi-Ngole
Inventor： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi-Ngole
CPC classification number: C12Q1/701 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/14021 , C12N2740/14022 , C12N2740/14043 , C12Q1/70
Abstract: Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.
Abstract translation: 公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。 通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。 在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。 本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。 本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。
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