公开(公告)号：US09044509B2

公开(公告)日：2015-06-02

申请号：US11669547

申请日：2007-01-31

Applicant: Walid M. Heneine ,  Thomas M. Folks ,  Robert Janssen ,  Ronald Otten ,  Jose Gerardo Garcia Lerma

Inventor： Walid M. Heneine ,  Thomas M. Folks ,  Robert Janssen ,  Ronald Otten ,  Jose Gerardo Garcia Lerma

IPC: A61K31/675 ,  A61K31/505 ,  A61K45/06 ,  A61K31/7072 ,  A61K31/513

CPC classification number: A61K31/675 ,  A61K9/0034 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/683 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

Abstract: A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.

Abstract translation: 提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。 在暴露于免疫缺陷型逆转录病毒之前，通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。 如果在暴露后24小时内以单一剂量提供，则该药物是有效的。 定期日剂量的方案对于在感染灵长类动物宿主后免疫缺陷逆转录病毒变得自我复制也是有效的。 用于控制群体内的逆转录病毒传播的方法包括在性暴露于免疫缺陷型逆转录病毒来源之前对具有高免疫缺陷型逆转录病毒感染的细菌组合的高风险亚群的施用，以排除免疫缺陷型逆转录病毒在自身复制中的自我复制 一个亚群的成员。

公开(公告)号：US20070265227A1

公开(公告)日：2007-11-15

申请号：US11669547

申请日：2007-01-31

Applicant: Walid Heneine ,  Thomas Folks ,  Robert Janssen ,  Ronald Otten ,  J. Garcia-Lerma

Inventor： Walid Heneine ,  Thomas Folks ,  Robert Janssen ,  Ronald Otten ,  J. Garcia-Lerma

IPC: A61K31/52 ,  A61K31/505 ,  A61K31/675 ,  A61P31/18

CPC classification number: A61K31/675 ,  A61K9/0034 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/683 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

Abstract: A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.

Abstract translation: 提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。 在暴露于免疫缺陷型逆转录病毒之前，通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。 如果在暴露后24小时内以单一剂量提供，则该药物是有效的。 定期日剂量的方案对于在感染灵长类动物宿主之后提供免疫缺陷型逆转录病毒变得自我复制的保护也是有效的。用于控制群体内的逆转录病毒传播的方法包括向接种免疫缺陷型逆转录病毒感染的高风险的亚群施用 性暴露于免疫缺陷型逆转录病毒来源之前的详细组合，以排除免疫缺陷逆转录病毒在亚群中成为自我复制。